[논문]The Analgesic Effect and Mechanisms of Dianthus chinensis L Extract in the mice.

Park, Soo-Hyun; Sim, Yun-Beom; Lee, Jin-Koo; Lim, Soon-Sung; Kim, Jin-Kyu; Suh, Hong-Won

The Analgesic Effect and Mechanisms of Dianthus chinensis L Extract in the mice. 원문보기

韓國資源植物學會誌 = Korean journal of plant resources, v.23 no.6, 2010년, pp.513 - 518

Park, Soo-Hyun (Department of Pharmacology, College of Medicine, Hallym University) , Sim, Yun-Beom (Department of Pharmacology, College of Medicine, Hallym University) , Lee, Jin-Koo (Department of Pharmacology, College of Medicine, Hallym University) , Lim, Soon-Sung (Institute of Natural Medicine, College of Medicine, Hallym University) , Kim, Jin-Kyu (Institute of Natural Medicine, College of Medicine, Hallym University) , Suh, Hong-Won (Department of Pharmacology, College of Medicine, Hallym University)

Abstract ▼ AI-Helper

In the present study, the antinociceptive profiles of Dianthus chinensis L extract were examined in ICR mice. Dianthus chinensis L extract administered orally (200 mg/kg) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests. In addition, Dianthus chinensis L extract attenuated the writhing numbers in the acetic acid-induced writhing test. Furthermore, the cumulative nociceptive response time for intrathecal (i.t.) injection of substance P ($0.7\;{\mu}g$) was diminished by Dianthus chinensis L extract. Intraperitoneal (i.p.) pretreatment with yohimbine ($\alpha_2$-adrenergic receptor antagonist) attenuated antinociceptive effect induced by Dianthus chinensis L extract in the writhing test. However, naloxone (opioid receptor antagonist) or methysergide (5-HT serotonergic receptor antagonist) did not affect antinociception induced by Dianthus chinensis L extract in the writhing test. Our results suggest that Dianthus chinensis L extract shows an antinociceptive property in various pain models. Furthermore, this antinociceptive effect of Dianthus chinensis L extract may be mediated by $\alpha_2$-adrenergic receptor, but not opioidergic and serotonergic receptors.

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가설 설정

As shown in Figs. 2b, cumulative nociceptive response times for i.t. administration of substance P was significantly diminished by 80%.

제안 방법

The intensity of radiant heat was adjusted so that the animal flicked its tail within 3 to 5 sec. For the hot-plate test, mice were individually placed on the 55℃ hot-plate apparatus (Itic Life Science, Woodland Hills, CA, USA, Model 39 Hot Plate) and then, the reaction time starting from the placement of the mouse on the hotplate to the time of licking the front paw was measured. Basal latency for the hot-plate test was approximately 9 sec.
However, the effect of this herb on pain is unclear. Therefore, in this study, we attempted to characterize antinociceptive profiles and mechanisms of Dianthus chinensis L extract in various pain models.

대상 데이터

All assessments for measuring antinociceptive properties of Dianthus chinensis L extract were carried out by blinded observers.
Male ICR mice (MJ Co., Seoul, Korea) weighing 20~25 g were used for all the experiments. Animals were housed 5 per cage in a room maintained at 22 ± 0.

성능/효과

In conclusion, our results suggest that Dianthus chinensis L extract shows an antinociceptive property in various pain models. Furthermore, this antinociceptive effect of Dianthus chinensis L extract may be mediated by α₂-adrenergic receptor, but not opioidergic and serotonergic receptors.
Moreover, Grumbach [1966] has shown that the effectiveness of analgesic agents in the tail-flick pain model is highly correlated with relief of human pain. Our results demonstrate that Dianthus chinensis L extract causes to prolong the tailflick and hot-plate response latencies, indicating the increase of nociceptive threshold.

참고문헌 (20)

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상세보기
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The Analgesic Effect and Mechanisms of Dianthus chinensis L Extract in the mice. 원문보기

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The Analgesic Effect and Mechanisms of Dianthus chinensis L Extract in the mice. 원문보기

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