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[국내논문] Extraction and Characteristics of Anti-obesity Lipase Inhibitor from Phellinus linteus 원문보기

Mycobiology, v.38 no.1, 2010년, pp.52 - 57  

Lee, Jong-Kug (Chungnam Agricultural Research and Extension Services) ,  Jang, Jeong-Hoon (Department of Life Science and Genetic Engineering, Paichai University) ,  Lee, Jong-Tae (Central Research Institute, Korea Ginseng Corporation) ,  Lee, Jong-Soo (Department of Life Science and Genetic Engineering, Paichai University)

Abstract ▼ AI-Helper 아이콘AI-Helper

To develop a potent anti-obesity lipase inhibitor from mushroom, the lipase inhibitory activities of various mushroom extracts were determined. Methanol extracts from Phellinus linteus fruiting body exhibited the highest lipase inhibitory activity (72.8%). The inhibitor was maximally extracted by tr...

주제어

#Anti-obesity   #Lipase inhibitor   #Phellinus linteus  

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대상 데이터

  • Unless otherwise specified, all chemicals and solvents were of analytical grade. Lipase (porcine pancreatic lipase, Type II), triolein as substrate, TES (N-Tris [hydroxymethyl] methyl-2-aminoethanesulfonic acid), taurocholic acid, gum arabic, HHL (Hip-His-Leu), pyrogallol, acetylcholinesterase, thrombin and fibrinogen were purchased from Sigma-Aldrich (St. Louis, MO, USA).
  • Mushrooms and chemicals. Mushrooms were obtained from Chungnam Agricultural Research and Extension Services (Yesan, Korea) and Baekma Agricultural Community of Buyea in Chungnam province. Unless otherwise specified, all chemicals and solvents were of analytical grade.

이론/모형

  • We used the Blois method[21] and DPPH to assay antioxidant activity. Superoxide dismutase (SOD) - like activity was assayed by the method of Marklund et al. [22].
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참고문헌 (29)

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    원문보기 상세보기

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    원문보기 상세보기

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  8. 8 Yu HE Lee DH Seo GS Cho SM Lee JS Characterization of a novel β-hydroxy-β-methyl glutaryl coenzyme A reductase-inhibitor from the mushroom, Pholiota adiposa Biotechnol Bioprocess Eng 2007 12 618 624 

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    상세보기

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    상세보기

  13. 13 Kim SG An GH Yoon SW Lee YC Ha SD A study on dietary supplement to reduce obesity by the mechanism of decreasing lipid and carbohydrate absorption Korean J Food Sci Technol 2003 35 519 526 

  14. 14 Yoshizumi K Hirano K Ando H Hirai Y Ida Y Tsuji T Lupane-type saponins from leaves of Acanthopanax sessiliflorus and their inhibitory activity on pancreatic lipase J Agric Food Chem 2006 54 335 341 16417288 

    상세보기

  15. 15 Yang HK Kim YS Bae HS Cho KH Shin JE Kim NJ Rhei rhizoma and chunghyuldan inhibit pancreatic lipase Nat Prod Sci 2003 9 38 43 

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    상세보기

  17. 17 Kim JH Kim HJ Kim C Jung H Kim YO Ju JY Development of lipase inhibitors from various derivatives of monascus pigment produced by Monascus fermentation Food Chem 2007 101 357 364 

    상세보기

  18. 18 Borgström B Erlanson C Interactions of serum albumin and other proteins with porcine pancreatic lipase Gastroenterology 1978 75 382 386 

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    상세보기

  20. 20 Zapf J Schoenle E Waldvogel M Sand I Froesch ER Effect of trypsin treatment of rat adipocytes on biological effects and binding of insulin and insulin-like growth factors: further evidence for the action of insulin-like growth factors through the insulin receptor Eur J Biochem 1981 113 605 609 7011799 

  21. 21 Blois MS Antioxidant determination by the use of a stable free radical Nature 1958 181 1199 1200 

  22. 22 Marklund S Marklund G Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase Eur J Biochem 1974 47 469 474 4215654 

    상세보기

  23. 23 Cushman DW Cheung HS Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung Biochem Pharmacol 1971 20 1637 1648 4355305 

    상세보기

  24. 24 Ellman GL Courtney KD Andres V Featherstone RM A new and rapid colorimetric determination of acetylcholinesterase activity Biochem Pharmacol 1961 7 88 95 13726518 

    상세보기

  25. 25 Fayek K El-Sayed ST Purification and properties of fibrinolytic enzyme from Bacillus subtilis Z Allg Mikrobiol 1980 20 375 382 6775426 

  26. 26 Lee JH Cho SM Kim HM Hong ND Yoo ID Immunostimulating activity of polysaccharides from mycelia of Phellinus linteus grown under different culture conditions J Microbiol Biotechnol 1996 6 52 55 

  27. 27 Lim JS Kim SH Park JS Choi JY Park SJ Shin KS Antitumor activity of the fruitbody extract of Basidiomycete , Phellius linteus J Microbiol 2001 39 121 125 

  28. 28 Park IH Jeon SY Lee HJ Kim SI Song KS A beta-secretase (BACE1) inhibitor hispidin from the mycelial cultures of Phellinus linteus Planta Med 2004 70 143 146 14994192 

    상세보기

  29. 29 Shon YH Lee JS Lee HW Kim JW Lim JK Kim CH Nam KS Antimutagenicity of Phellinus linteus in Salmonella typhimurium J Microbiol 1999 37 136 140 

    원문보기 상세보기

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