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논문 상세정보

Triazenoindazoles and Triazenopyrazolopyridines: Design, Synthesis, and Cytotoxic Activity

Abstract

Several triazenoindazoles 3a-e and triazinopyrazolopyridines 6a-i were prepared through the reaction of the corresponding 3-amino-4-chloroindazole and 3-aminopyrazolopyridine diazonium salts 2 and 5 with a number of secondary amines. All compounds were evaluated for their in vitro cytotoxic activity on three cell lines, HepG2, MCF7, and HeLa. Most compounds inhibited cell growth with $IC_{50}$ less than $0.1\;{\mu}M$. Compound 6d was the most potent, with an $IC_{50}$ of $0.03\;{\mu}M$ against HepG2 and $0.05\;{\mu}M$ against MCF7 and HeLa cells.

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