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Journal of plant biotechnology = 식물생명공학회지, v.37 no.3, 2010년, pp.250 - 261
염정원 (한국생명공학연구원 식물시스템공학연구센터) , 전재흥 (한국생명공학연구원 식물시스템공학연구센터) , 정혁 (한국생명공학연구원 식물시스템공학연구센터) , 김현순 (한국생명공학연구원 식물시스템공학연구센터)
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The expression of vaccine antigens in transgenic plants has the potential to provide a convenient, stable, safe approach for oral vaccination alternative to traditional parenteral vaccines. Over the past two decades, many different vaccine antigens expressed via the plant nuclear genome have elicite...
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| 핵심어 | 질문 | 논문에서 추출한 답변 |
|---|---|---|
| 백신의 장점은 무엇인가? | 경구용 식물 백신 (plant derived oral vaccine)은 병원체의 항원유전자를 식물에 도입시켜 항원단백질을 합성하는 식물체를 만들어 경구로 투여하고자 하는 기술로서, 1980년대 중반 처음 아이디어가 제시된 후 1990년 Cutiss와 Cardineau 에 의해 처음 시도되어 현재까지 많은 연구가 진행되고 있는 분야이다. 식물을 생산-기반으로 하는 백신은 ① 사람이나 동물의 병원체를 가지지 않는 시스템에서 항원단백질만을 목표로 발현하므로 안정성 확보가 가능하고, ② 식품의 섭식을 통해 처치되므로 백신의 투여에 고통이 따르지 않고 기존 사용 백신에 비하여 거부감이 없으며, ③ 농업체계를 활용한 대량생산으로 백신 생산비용이 저렴하고, ④ 백신의 보관에 cold-chain을 요구하지 않는 등 많은 장점을 가지고 있다. 더욱이, 식물유래 경구백신은 소화관. | |
| 경구용 식물 백신은 무엇인가? | 경구용 식물 백신 (plant derived oral vaccine)은 병원체의 항원유전자를 식물에 도입시켜 항원단백질을 합성하는 식물체를 만들어 경구로 투여하고자 하는 기술로서, 1980년대 중반 처음 아이디어가 제시된 후 1990년 Cutiss와 Cardineau 에 의해 처음 시도되어 현재까지 많은 연구가 진행되고 있는 분야이다. 식물을 생산-기반으로 하는 백신은 ① 사람이나 동물의 병원체를 가지지 않는 시스템에서 항원단백질만을 목표로 발현하므로 안정성 확보가 가능하고, ② 식품의 섭식을 통해 처치되므로 백신의 투여에 고통이 따르지 않고 기존 사용 백신에 비하여 거부감이 없으며, ③ 농업체계를 활용한 대량생산으로 백신 생산비용이 저렴하고, ④ 백신의 보관에 cold-chain을 요구하지 않는 등 많은 장점을 가지고 있다. | |
| Vaccination의 문제점은 무엇인가? | 이러한 장점들과는 달리 아직도 불충분한 발현양의 문제, 면역관용의 우려 제기 및 제어된 공간이 아닌 곳에서의 재배일 경우 대부분의 유전자변형작물들이 가지는 환경 위해성에 대한 검정 등과 같은 해결해야 할 문제들이 극복되지 못하고 있다. 또한, 연구 초기의 식물경구백신이라는 개념은 어떠한 가공 과정도 거치치 않고 항원의 발현 대상 기관 그 자체를 백신으로 취하는 것이었으나 항원의 양을 결정짓기 위한 표준화가 어렵다는 점 등의 이유로 최근에는 순수분리정제를 비롯한 단순 일차 가공을 포함하는 개념으로 좁혀지고 있는 실정이다. |
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