The hypoglycemic effects of red ginsgeng-chungkukjang plus seaweeds, green laver and sea tangle, in streptozotocin (STZ)-induced diabetic rats were investigated. Five groups of male Sprague-Dawley rats weighing $140\pm10$ g (10 animals/group) were fed for four weeks with the following: no...
The hypoglycemic effects of red ginsgeng-chungkukjang plus seaweeds, green laver and sea tangle, in streptozotocin (STZ)-induced diabetic rats were investigated. Five groups of male Sprague-Dawley rats weighing $140\pm10$ g (10 animals/group) were fed for four weeks with the following: nondiabetic control (NC group); STZ-induced diabetic (D group); diabetic rats fed 3% red ginseng (20%, w/w)-chungkukjang (D-RC group); diabetic rats fed RC containing 10% (w/w) green laver powder (D-RCG group); diabetic rats fed RC containing 10% (w/w) sea tangle powder (D-RCS group). Partially normalized body weight gain, FER, and blood glucose levels were observed in the D-RC, D-RCG and D-RCS groups as compared to the D group. In these three groups, serum levels of triglycerides, total cholesterol, and LDL-cholesterol were found to be lower than in the D group, whereas HDL-cholesterol levels increased. Serum insulin level in D was significantly lower than that of NC, although D-RC, D-RCG, and D-RCS almost recovered to the NC. Serum ALT activity was markedly increased in the D group, while the serum ALT levels in the D-RC, D-RCG, and D-RCS were almost the same as the NC group. Due to diabetes, hepatic xanthine oxidase (XO) activity was significantly increased and administration of red ginseng-chungkukjang or seaweeds resulted in decreased levels of the XO activity. Activity of hepatic antioxidant enzymes (superoxide dismutase and glutathione peroxidase) were significantly decreased in the D group, but the activity in the D-RC, D-RCG, and D-RCS groups were similar to that of the NC group. Results of the present study indicate that supplementation of red ginseng-chungkukjang with seaweed after the onset of diabetes ameliorated hyperglycemia via an increase in serum insulin.
The hypoglycemic effects of red ginsgeng-chungkukjang plus seaweeds, green laver and sea tangle, in streptozotocin (STZ)-induced diabetic rats were investigated. Five groups of male Sprague-Dawley rats weighing $140\pm10$ g (10 animals/group) were fed for four weeks with the following: nondiabetic control (NC group); STZ-induced diabetic (D group); diabetic rats fed 3% red ginseng (20%, w/w)-chungkukjang (D-RC group); diabetic rats fed RC containing 10% (w/w) green laver powder (D-RCG group); diabetic rats fed RC containing 10% (w/w) sea tangle powder (D-RCS group). Partially normalized body weight gain, FER, and blood glucose levels were observed in the D-RC, D-RCG and D-RCS groups as compared to the D group. In these three groups, serum levels of triglycerides, total cholesterol, and LDL-cholesterol were found to be lower than in the D group, whereas HDL-cholesterol levels increased. Serum insulin level in D was significantly lower than that of NC, although D-RC, D-RCG, and D-RCS almost recovered to the NC. Serum ALT activity was markedly increased in the D group, while the serum ALT levels in the D-RC, D-RCG, and D-RCS were almost the same as the NC group. Due to diabetes, hepatic xanthine oxidase (XO) activity was significantly increased and administration of red ginseng-chungkukjang or seaweeds resulted in decreased levels of the XO activity. Activity of hepatic antioxidant enzymes (superoxide dismutase and glutathione peroxidase) were significantly decreased in the D group, but the activity in the D-RC, D-RCG, and D-RCS groups were similar to that of the NC group. Results of the present study indicate that supplementation of red ginseng-chungkukjang with seaweed after the onset of diabetes ameliorated hyperglycemia via an increase in serum insulin.
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문제 정의
However, no reports are available on the effect of red ginseng-chungkukjang with either green laver or sea tangle on diabetes. Therefore, this study was designed to evaluate the hypoglycemic effect of red ginseng-chungkukjang with either green laver or sea tangle powder for use as a healthy functional food. We observed im-provements in the body weight gain, feed efficiency ratio, blood glucose, serum insulin, lipid profile, and ROS generating and scavenging enzyme activity in STZ-induced diabetic rats.
가설 설정
3)NS: not significant.
4)Values are means±SD of 10 rats.
제안 방법
After the induction of diabetes, animals were fed the experimental diets for 4 weeks, and the subsequent body weight gain, the amount of feed intake, and the FER were examined (Table 2). At the beginning of the experi-ment, the average body weights of the animals among the five groups were not significantly different (178.
RCG or RCS was prepared by blending the RC powder with green laver or sea tangle powder. Contents of red ginseng, sea tan-gle, or green laver powders contained in RC, RCS, or RCG were adjusted to 20%, 10%, and 10% of chungkukjang, respectively.
, Seoul, Korea) and acclimatized to their environment for 1 week before commencement of the experiments. Five groups of rats (10 rats per group) were fed for 4 weeks with the following; non-diabetic control (NC), STZ-induced diabetic control (D), diabetic rats fed diet supplemented with red ginseng-chungkukjang (DRC), diabetic rats fed diet supplemented (RC) with green laver (D-RCG), diabetic rats fed diet supplemented RC with sea tangle (D-RCS) (Table 1). The rats were in-dividually housed in stainless steel wire bottom cages in a room maintained at 20±2 oC and 60±5% relative humidity.
데이터처리
Statistical comparisons of differences between the different groups were carried out by two-way ANOVA test followed by Duncan's multiple range test using SPSS statistical software package (Ver-sion 12.0, SPSS Inc., Chicago, IL, USA).
이론/모형
, Korea). LDL-cholesterol was calculated by the method of Friedewald et al. (24). ALT activity was assayed by a commercial kit (Asan Pharmaceutical Co.
GPX activity was measured by the method of Paglia and Valentine (28) and the activity was defined as the amount of NADPH oxidized/min/mg protein. Protein content was determined by the Lowry method (29) with bovine serum albumin as a standard.
Red ginseng-chungkukjang powder (RC) was prepared by the method of Shin et al. (16). RCG or RCS was prepared by blending the RC powder with green laver or sea tangle powder.
All rats were allowed free access to diets and drinking water. The experimental protocols were conducted in accordance with internation-ally accepted principles for laboratory animal use and care as found in KFDA guidelines.
성능/효과
2)Values are means±SD of 10 rats and values with different superscripts indicate significant differences (p<0.05).
2)Values are means±SD of 10 rats and values with different superscripts within the same column indicate significant differences (p<0.05).
98 g). Final body weight, weight gain and FER were significantly lower in the diabetic groups than in the NC group; however, they were significantly higher in the red ginseng-chungkukjang supplemented diets groups (RC, RCG and RCS) than in the D group during the experimental periods. While, food intakes in all dia-betic groups were significantly higher than that of the NC group, there was no significant difference among all diabetic groups.
In conclusion, our study provides experimental evi-dence that the mixture of red ginseng-chungkukjang with either green laver or sea tangle powder may regulate hy-perglycemia and hyperlipidemia via an increase in insulin. However, further study is needed to confirm these effects in humans.
1. The levels of TG, total cholesterol and LDL-cholesterol in D group were sig-nificantly higher than those of the NC group, the level of HDL-cholesterol was significantly lower than that of NC. TG and LDL-cholesterol in animals fed RC, RCG, or RCS supplemented diet were normalized to levels similar to the NC group, total cholesterol except RCS group lower than that of D group.
후속연구
In conclusion, our study provides experimental evi-dence that the mixture of red ginseng-chungkukjang with either green laver or sea tangle powder may regulate hy-perglycemia and hyperlipidemia via an increase in insulin. However, further study is needed to confirm these effects in humans.
참고문헌 (50)
Robert L, Labat-Robert J. 2005. The metabolic syndrome
Cho YJ, Bang MA. 2004. Effects of dietary seaweed on blood glucose, lipid and glutathione enzymes in streptozotocine-induced diabetic rats. J Korean Soc Food Sci Nutr
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