말라세지아성 외이염에 대한 아로마치료법 (아로마오일)과 약침치료법 (아피톡신)을 적용하여 임상증상 개선효과를 알아보기 위해 본 연구를 실시하였다. 실험군 5두는 아로마치료와 약침을 실시하였고 대조군 5두는 케토코나졸을 적용하였다. 임상증상은 대조군과 실험군에서 치료 전에 비해 각각 치료 후 2주 후에 유의성 있는 개선효과를 나타내었다 (p < 0.01, p < 0.05). ALT 수치는 대조군에서 치료 전에 비해 치료 후 1주, 2주 후에 각각 유의성 있는 증가소견을 나타내었다 (p < 0.05, p < 0.01). 실험군의 ALT 수치의 변화는 대조군에 비해 치료 1주 후, 2주 후에 각각 유의성 있는 감소소견을 나타내었다 (p < 0.05, p < 0.01). 결론적으로 말라세지아성 외이염에 대한 아로마치료법(아로마 오일)과 약침치료법은 효과가 있으며 대조군에 비해 간독성은 적은 것으로 나타났다.
말라세지아성 외이염에 대한 아로마치료법 (아로마오일)과 약침치료법 (아피톡신)을 적용하여 임상증상 개선효과를 알아보기 위해 본 연구를 실시하였다. 실험군 5두는 아로마치료와 약침을 실시하였고 대조군 5두는 케토코나졸을 적용하였다. 임상증상은 대조군과 실험군에서 치료 전에 비해 각각 치료 후 2주 후에 유의성 있는 개선효과를 나타내었다 (p < 0.01, p < 0.05). ALT 수치는 대조군에서 치료 전에 비해 치료 후 1주, 2주 후에 각각 유의성 있는 증가소견을 나타내었다 (p < 0.05, p < 0.01). 실험군의 ALT 수치의 변화는 대조군에 비해 치료 1주 후, 2주 후에 각각 유의성 있는 감소소견을 나타내었다 (p < 0.05, p < 0.01). 결론적으로 말라세지아성 외이염에 대한 아로마치료법(아로마 오일)과 약침치료법은 효과가 있으며 대조군에 비해 간독성은 적은 것으로 나타났다.
Aromatherapy and apipuncture was evaluated for its efficacy on canine Malassezia-related otitis externa. Ten dogs with Malassezia-related otitis externa were used in the present study. The control group was treated with ketoconazole, and the experimental group was treated with aromatherapy (topical ...
Aromatherapy and apipuncture was evaluated for its efficacy on canine Malassezia-related otitis externa. Ten dogs with Malassezia-related otitis externa were used in the present study. The control group was treated with ketoconazole, and the experimental group was treated with aromatherapy (topical aroma-oil drop) and apipuncture (injection-acupuncture of apitoxin). Clinical scores of the control group after 2-week treatment (p < 0.01) revealed a significant decrease compared with scores of pre-treatment. Experimental group scores after 2-week treatment revealed a significant decrease compared with scores of pre-treatment (p < 0.05). In the control group, ALT levels were significantly increased in the 1-week treatment (p < 0.05) and the 2-week treatment (p < 0.01), compared with the pretreatment levels. The experimental group ALT levels did not significantly change after 1-week and the 2-week treatments, compared with pre-treatment. ALT levels of the experimental group after the 1-week treatment (p < 0.05) and the 2-week treatment (p < 0.01), was significantly lower than those of the control group. In conclusion, a combination therapy of apipuncture and topical aroma-oil drop is not hepatotoxic and similar to the effect of ketoconazole treatment for Malassezia-related otitis externa in dogs.
Aromatherapy and apipuncture was evaluated for its efficacy on canine Malassezia-related otitis externa. Ten dogs with Malassezia-related otitis externa were used in the present study. The control group was treated with ketoconazole, and the experimental group was treated with aromatherapy (topical aroma-oil drop) and apipuncture (injection-acupuncture of apitoxin). Clinical scores of the control group after 2-week treatment (p < 0.01) revealed a significant decrease compared with scores of pre-treatment. Experimental group scores after 2-week treatment revealed a significant decrease compared with scores of pre-treatment (p < 0.05). In the control group, ALT levels were significantly increased in the 1-week treatment (p < 0.05) and the 2-week treatment (p < 0.01), compared with the pretreatment levels. The experimental group ALT levels did not significantly change after 1-week and the 2-week treatments, compared with pre-treatment. ALT levels of the experimental group after the 1-week treatment (p < 0.05) and the 2-week treatment (p < 0.01), was significantly lower than those of the control group. In conclusion, a combination therapy of apipuncture and topical aroma-oil drop is not hepatotoxic and similar to the effect of ketoconazole treatment for Malassezia-related otitis externa in dogs.
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제안 방법
To confirm the Malassezia infections, the samples were inoculated on Sabouraud dextrose agar (SD agar®, Asan pharmaceutical, Korea) at 30℃ with an incubation period of 2-5 days and were identified by tandard microbiological procedure. Each dog was re-evaluated at pre, 1 week and 2 weeks after treatment.
Pruritus, cerumen, redness, odor and number of yeasts were chosen as the score calculation elements, and each element was divided into several phases (Table 1). Pruritus, cerumen, redness and odor in clinical score elements were evaluated by owners for objective estimation.
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