[논문]Bioactive Compounds Extracted from Gamtae (Ecklonia cava) by Using Enzymatic Hydrolysis, a Potent <tex>${\\alpha}$</tex>-Glucosidase and <tex>${\\alpha}$</tex>-Amylase Inhibitor, Alleviates Postprandial Hyperglycemia in Diabetic Mice

Lee, Seung-Hong; Park, Mi-Hwa; Han, Ji-Sook; Jeong, Yoonhwa; Kim, Misook; Jeon, You-Jin

doi:10.1007/s10068-012-0150-x

[국내논문] Bioactive Compounds Extracted from Gamtae (Ecklonia cava) by Using Enzymatic Hydrolysis, a Potent ${\\alpha}$-Glucosidase and ${\\alpha}$-Amylase Inhibitor, Alleviates Postprandial Hyperglycemia in Diabetic Mice

Food science and biotechnology, v.21 no.4, 2012년, pp.1149 - 1155

Lee, Seung-Hong (Department of Marine Life Science, Jeju National University) , Park, Mi-Hwa (Department of Food Science and Nutrition, Pusan National University) , Han, Ji-Sook (Department of Food Science and Nutrition, Pusan National University) , Jeong, Yoonhwa (Department of Food Science and Nutrition, Dankook University) , Kim, Misook (Department of Food Science and Nutrition, Dankook University) , Jeon, You-Jin (Department of Marine Life Science, Jeju National University)

Abstract ▼ AI-Helper

This study was designed to investigate whether the brown alga gamtae (Ecklonia cava) may inhibit ${\alpha}$-glucosidase and ${\alpha}$-amylase activities, and alleviate postprandial hyperglycemia in streptozotocin-induced diabetic mice. For that purpose, we prepared an enzymatic hydrolysate from gamtae (EHG) by using the carbohydrase, Celluclast. EHG evidenced prominent inhibitory effect against ${\alpha}$-glucosidase and ${\alpha}$-amylase. The $IC_{50}$ values of EHG against ${\alpha}$-glucosidase and ${\alpha}$-amylase were 0.62 and 0.59 mg/mL, respectively, which evidenced the higher activities than that of acarbose. EHG did not exert any cytotoxic effect in human umbilical vein endothelial cells (HUVECs) at various concentrations (from 0.25 to 2 mg/mL). The increase of postprandial blood glucose levels were significantly suppressed in the EHG administered group than those in the streptozotocin-induced diabetic or normal mice. Moreover, the area under curve (AUC) was significantly reduced via EHG administration (6,102 vs. 10,425 $mg{\cdot}min$/dL) in the diabetic mice as well as it delays absorption of dietary carbohydrates. These result indicated that EHG might be a potent inhibitor for ${\alpha}$-glucosidase and ${\alpha}$-amylase.

Keyword

참고문헌 (33)

Nature P. Zimmet 414 782 2001 10.1038/414782a Zimmet P, Alberti K, Shaw J. Global and societal implications of the diabetes epidemic. Nature 414: 782-787 (2001)

상세보기
Diabetes Res. Clin. Pr. A.D. Baron 40 S51 1998 10.1016/S0168-8227(98)00043-6 Baron AD. Postprandial hyperglycemia and α-glucosidase inhibitors. Diabetes Res. Clin. Pr. 40: S51-S55 (1998)

상세보기
Food Chem. M.R. Bhandari 106 247 2008 10.1016/j.foodchem.2007.05.077 Bhandari MR, Jong-Anurakkun N, Hong G, Kawabata J. α-Glucosidase and α-amylase inhibitory activities of Nepalese medicinal herb pakhanbhed (Bergenia ciliata, Haw.). Food Chem. 106: 247-252 (2008)

상세보기
J. Int. Med. Res. N. Saito 26 219 1998 10.1177/030006059802600501 Saito N, Sakai H, Sekihara H, Yajima Y. Effect of an α-glucosidase inhibitor (volibose), in combination with sulphonilureas, on glycaemic control in type 2 diabetes patients. J. Int. Med. Res. 26: 219-232 (1998)

상세보기
Expert Opin. Pharmaco. J.P. Sels 1 149 1999 10.1517/14656566.1.1.149 Sels JP, Huijberts MS, Wolffenbuttel BH. Miglitol, a new α-glucosidase inhibitor. Expert Opin. Pharmaco. 1: 149-156 (1999)

상세보기
Diabetes Obes. Metab. E. Stand 1 215 1999 10.1046/j.1463-1326.1999.00021.x Stand E, Baumgartl HJ, Fuchtenbusch M, Stemplinger J. Effect of acarbose on additional insulin therapy in type 2 diabetic patients with late failure of sulphonylurea therapy. Diabetes Obes. Metab. 1: 215-220 (1999)

상세보기
J. Diabetes Complicat. M. Hanefeld 12 228 1998 10.1016/S1056-8727(97)00123-2 Hanefeld M. The role of acarbose in the treatment of non-insulindependent diabetes mellitus. J. Diabetes Complicat. 12: 228-237 (1998)

상세보기
Am. J. Gastroenterol. F.L. Diaz-Gutierrez 93 481 1998 10.1111/j.1572-0241.1998.481_1.x Diaz-Gutierrez FL, Ladero JM, Diaz-Rubio M. Acarbose-induced acute hepatitis. Am. J. Gastroenterol. 93: 481-482 (1998)

상세보기
Diabetes Metab. G. Charpentier 26 73 2000 Charpentier G, Riveline JP, Varroud-Vial M. Management of drugs affecting blood glucose in diabetic patients with renal failure. Diabetes Metab. 26: 73-85 (2000)
J. Agr. Food. Chem. T. Matsui 55 99 2007 10.1021/jf0627672 Matsui T, Tanaka T, Tamura S, Toshima A, Miyata Y, Tanaka K, Matsumoto K. α-Glucosidase inhibitory profile of catechins and theaflavins. J. Agr. Food. Chem. 55: 99-105 (2007)

상세보기
Eur. J. Pharmacol. S.J. Heo 615 252 2009 10.1016/j.ejphar.2009.05.017 Heo SJ, Hwang JY, Choi JI, Han JS, Kim HJ, Jeon YJ. Diphlorethohydroxycarmalol isolated from Ishige okamurae, a brown algae, a potent α-glucosidase and α-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice. Eur. J. Pharmacol. 615: 252-256 (2009)

상세보기
Food Chem. Toxicol. S.H. Lee 48 2633 2010 10.1016/j.fct.2010.06.032 Lee SH, Park MH, Heo SJ, Kang SM, KO SC, Han JS, Jeon YJ. Dieckol isolated from Ecklonia cava inhibits α-glucosidase and α-amylase in vitro, and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice. Food Chem. Toxicol. 48: 2633-2637 (2010)

상세보기
B. Halliwell 105 1999 Free Radicals in Biology and Medicine Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine. Halliwell B, Gutteridge JMC (eds). Oxford Science Publications, Oxford, UK. pp. 105-199 (1999)
Bioresource Technol. S.J. Heo 96 1613 2005 10.1016/j.biortech.2004.07.013 Heo SJ, Park EJ, Lee KW, Jeon YJ. Antioxidant activities of enzymatic extracts from brown seaweeds. Bioresource Technol. 96: 1613-1623 (2005)

상세보기
Process Biochem. K.N. Kim 41 2393 2006 10.1016/j.procbio.2006.06.028 Kim KN, Heo SJ, Song CB, Lee JH, Heo MS, Yeo IK, Kang KA, Hyun JW, Jeon YJ. Protective effect of Ecklonia cava enzymatic extracts on hydrogen peroxide-induced cell damage. Process Biochem. 41: 2393-2401 (2006)

상세보기
Carbohyd. Polym. Y. Athukorala 66 184 2006 10.1016/j.carbpol.2006.03.002 Athukorala Y, Jung WK, Vasanthan T, Jeon YJ. An anticoagulative polysaccharide from an enzymatic hydrolysate of Ecklonia cava. Carbohyd. Polym. 66: 184-191 (2006)

상세보기
Food Chem. Toxicol. Y. Athukorala 44 1065 2006 10.1016/j.fct.2006.01.011 Athukorala Y, Kim KN, Jeon YJ. Antiproliferative and antioxidant properties of an enzymatic hydrolysate from brown alga, Ecklonia cava. Food Chem. Toxicol. 44: 1065-1074 (2006)

상세보기
Mar. Biotechnol. G.N. Ahn 10 278 2008 10.1007/s10126-007-9062-9 Ahn GN, Hwang IS, Park EJ, Kim JH, Jeon YJ, Lee JH, Park JW, Jee YH. Immunomodulatory effects of an enzymatic extract from Ecklonia cava on murine splenocytes. Mar. Biotechnol. 10: 278-289 (2008)

상세보기
J. Sci. Food. Agr. S.H. Lee 90 349 2010 10.1002/jsfa.3833 Lee SH, Heo SJ, Hwang JY, Han JS, Jeon YJ. Protective effects of enzymatic digest from Ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells. J. Sci. Food. Agr. 90: 349-356 (2010)

상세보기
Biosci. Biotech. Bioch. J. Watanabe 61 177 1997 10.1271/bbb.61.177 Watanabe J, Kawabata J, Kurihara H, Niki R. Isolation and identification of α-glucosidase inhibitors from tochucha (Eucommia ulmoides). Biosci. Biotech. Bioch. 61: 177-178 (1997)

상세보기
Mutat. Res. R. Fautz 253 173 1991 10.1016/0165-1161(91)90130-Z Fautz R, Husen B, Hechenberger C. Application of the neutral red assay (NR assay) to monolayer cultures of primary hepatocytes: Rapid colorimetric viability determination for the unscheduled DNA synthesis test (UDS). Mutat. Res. 253: 173-179 (1991)

상세보기
J. Korean Soc. Food Sci. Nutr. J.S. Kim 33 1133 2004 10.3746/jkfn.2004.33.7.1133 Kim JS. Effect of Rhemanniae Radix on the hyperglycemic mice induced with streptozotocin. J. Korean Soc. Food Sci. Nutr. 33: 1133-1138 (2004)

원문보기 상세보기
J. Med. D.M. Gray 29 1225 1995 Gray DM. Carbohydrate digestion and absorption role of small intestine. New Engl. J. Med. 29: 1225-1230 (1995)
Drugs A.J. Krentz 65 385 2005 10.2165/00003495-200565030-00005 Krentz AJ, Bailey CJ. Oral antidiabetic agents. Current role in type 2 diabetes mellitus. Drugs 65: 385-411 (2005)

상세보기
Endocrin. Metab. Clin. H.E. Lebovitz 26 539 1997 10.1016/S0889-8529(05)70266-8 Lebovitz HE. α-Glucosidase inhibitors. Endocrin. Metab. Clin. 26: 539-551 (1997)

상세보기
Agric. Biol. Chem. Tokyo Y. Hara 54 1939 1990 10.1271/bbb1961.54.1939 Hara Y, Honda M. The inhibition of α-amylase by tea polyphenols. Agric. Biol. Chem. Tokyo 54: 1939-1945 (1990)

상세보기
Diabetes Res. Clin. Pr. I. Inoue 36 143 1997 10.1016/S0168-8227(97)00045-4 Inoue I, Takahashi K, Noji S, Awata T, Negishi K, Katayama S. Acarbose controls postprandial hyper-proinsulinemia in non-insulindependent diabetes mellitus. Diabetes Res. Clin. Pr. 36: 143-151 (1997)

상세보기
Science J.W. Dennis 236 582 1987 10.1126/science.2953071 Dennis JW, Laferte S, Waghorne C, Breitman ML, Kerbel RS. β1-6 Branching of Asn-linked oligosaccharides is directly associated with metastasis. Science 236: 582-585 (1987)

상세보기
Nature R.A. Gruters 330 74 1987 10.1038/330074a0 Gruters RA, Neefjes JJ, Tersmette M, De Goede REY, Tulp A, Huisman HG, Miedema F, Ploegh HL. Interference with HIVinduced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. Nature 330: 74-77 (1987)

상세보기
Glycobiology B. Winchester 2 199 1992 10.1093/glycob/2.3.199 Winchester B, Fleet GW. Amino-sugar glycosidase inhibitors: Versatile tools for glycobiologists. Glycobiology 2: 199-210 (1992)

상세보기
J. Ethnopharmacol. Y. Li 99 239 2005 10.1016/j.jep.2005.02.030 Li Y, Wen S, Kota BP, Peng G, Li GQ, Yamahara J. Punica granatum flower extract, a potent α-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats. J. Ethnopharmacol. 99: 239-244 (2005)

상세보기
Life Sci. J.Y. Cherng 78 1181 2006 10.1016/j.lfs.2005.06.050 Cherng JY, Shih MF. Improving glycogenesis in Streptozotocin (STZ) diabetic mice after administration of green algae Chlorella. Life Sci. 78: 1181-1186 (2006)

상세보기
Biochem. Bioph. Res. Co. S.I. Kang 373 264 2008 Kang SI, Jin YJ, Ko HC, Choi SY, Hwang JH, Whang I, Kim MH, Shin HS, Jeong HB, Kim SJ. Petalonia improves glucose homeostasis in streptozotocin-induced diabetic mice. Biochem. Bioph. Res. Co. 373: 264-269 (2008)

저자의 다른 논문 :

활용도 분석정보

상세보기

다운로드

내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

[국내논문] Bioactive Compounds Extracted from Gamtae (Ecklonia cava) by Using Enzymatic Hydrolysis, a Potent ${\\alpha}$-Glucosidase and ${\\alpha}$-Amylase Inhibitor, Alleviates Postprandial Hyperglycemia in Diabetic Mice

Abstract ▼ AI-Helper

Keyword

참고문헌 (33)

이 논문을 인용한 문헌

저자의 다른 논문 :

활용도 분석정보

활용도 Top5 논문

관련 콘텐츠

원문 URL 링크

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

[국내논문] Bioactive Compounds Extracted from Gamtae (Ecklonia cava) by Using Enzymatic Hydrolysis, a Potent ${\\alpha}$-Glucosidase and ${\\alpha}$-Amylase Inhibitor, Alleviates Postprandial Hyperglycemia in Diabetic Mice

Abstract ▼ AI-Helper

Keyword

참고문헌 (33)

이 논문을 인용한 문헌

저자의 다른 논문 :

이승홍 (16) Park, Mi Hwa (3) 한지숙 (93) 정윤화 (65) 김미숙 (32) 전유진 (168)

활용도 분석정보

활용도 Top5 논문 더보기

관련 콘텐츠

원문 URL 링크

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

활용도 Top5 논문