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NTIS 바로가기생명과학회지 = Journal of life science, v.23 no.10 = no.162, 2013년, pp.1209 - 1215
Graphene is an allotrope of carbon that is composed of one-atom-thick planar sheets. It is known to have a preventive effect on cancer in photothermal therapy and a protective effect in DNA oxidation. The effect of graphene on oxidative stress and matrix metalloproteinases (MMPs) was investigated in...
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핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
그래핀이란? | 그래핀(graphene)은 원자 하나의 두께를 가지는 흑연(graphite)의 단층으로서 탄소구조체들 중 하나이다. 그래핀은 최근 의학분야에서 광열요법을 이용한 암 발생의 예방효과와 DNA의 산화에 대한 보효효과를 가진다고 밝혀진 바 있다. | |
활성산소종의 부정적 영향은? | 이러한 free radical 중에서 활성산소종(reactive oxygen species, ROS)으로 superoxide, hydroxyl radical, singlet oxygen, hydrogen peroxide 등이 있다. 활성산소종은 단백질 효소의 불활성화, 지질과산화, DNA변성 등을 일으켜 세포의 정상적인 대사과정에 오류를 유발하고, 암이나 심장질환, 뇌혈관질환, 동맥경화, 고혈압, 당뇨병, 파킨슨질병 등 수많은 질병을 일으키는 것으로 보고되었다[26]. 이러한 질환들을 유발시키는 활성산소의 발생을 억제하기 위하여 우리 몸에는항산화 시스템이 작용하고 있다. | |
활성산소의 발생은 나이가 들수록 어떻게 변화하는가? | 체내에 존재하는 항산화효소는 superoxide를 산소로 전환시키는 superoxide dismutase (SOD), hydrogen peroxidase 및 catalase를 포함한다[4]. 활성산소는 나이가 들어갈수록 생성량이 증가하여 효소의 활성을 상실시킬 뿐만 아니라 DNA, RNA 및 세포막을 손상시키고 결국 세포사를 일으키고 조직 손상을 증가 시켜 암과 같은 노화관련질환을 유발시킨다고 보고되었다[1, 28]. |
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