최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기생약학회지, v.45 no.4 = no.179, 2014년, pp.300 - 314
서창섭 (한국한의학연구원 한약방제연구그룹) , 김온순 (한국한의학연구원 한약방제연구그룹) , 신현규 (한국한의학연구원 한약방제연구그룹)
An ultra-performance liquid chromatography-electrospray ionization-mass spectrometer (UPLC-ESI-MS) method was established for the simultaneous quantification of eighteen marker compounds in traditional Korean formula, Cheonwangbosimdan (CWBSD). In addition, we evaluated the antioxidant effects of CW...
* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.
핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
−天王補心丹을 구성하는 구성 생약의 주요 성분은? | LC-MS/MS 분석조건 확립 −天王補心丹을 구성하는 구성 생약의 주요 성분인 aucubin, catalpol(이상 생건지황), β-asarone(석창포), ginsenoside Rb1, ginsenoside Rg1(이상 인삼), nodakenin(당귀), schizandrin, gomisin A(이상 오미자), 5-HMF(천문동), myricetin(백자인), spinosin(산조인), cinnamic acid, harpagide, (E)-harpagoside(이상 현삼), salvianolic acid, tanshinone IIA(이상 단삼), platycodin D(길경) 및 3,4,5-trimethoxycinnamic acid(원지) 등 18종 성분에 대하여 LC-MS/MS를 이용하여 동시 정량을 실시하였다. 역상 UPLC 조건에서 UPLC BEH C18(2. | |
−天王補心丹 추출물에서 DPPH 라디칼의 소거활성을 측정한 결과는? | 4A). DPPH 라디칼의 소거활성 또한 ABTS 라디칼의 소거활성과 유사하게 농도의존적인 증가를 나타냈다. 추출물 25, 50, 100, 200 및 400 μg/mL 농도에서 각각 4. | |
−天王補心丹 추출물에서 ABTS 라디칼의 소거활성을 측정한 결과는? | 天王補心丹 추출물의 항산화 효능 −天王補心丹의 항산화 효능을 평가하고자 추출물을 농도별로 조제한 후 ABTS와 DPPH 라디칼 소거활성을 측정하였다. ABTS 라디칼의 소거활성을 비교한 결과 추출물의 농도가 증가함에 따라 ABTS 라디칼 소거활성이 증가하는 경향을 보였다. 天王補心丹 추출물 25, 50, 100, 200 및 400 μg/mL 농도에서 각각 9. |
Wei, Y. L. (1990) Seuideukhyobang, 217. Esdang, Seoul.
Herbal formulation Professors of Korean Medicine (2003) Herbal formulation, 329-331. Younglimsa, Seoul.
Kim, N. J., Kong, Y. Y. and Chang, S. W. (1988) Studies on the efficacy of combined preparation of crude drugs (XXXVII). The effects of Chunwangboshimdan on the central nervous system and cardio-vascular system. Kor. J. Pharmacogn. 19: 208-215.
Lee, J. Y., Jung, I. C. and Lee, S. R. (2002) Effects of Chenwhangbosimdan (CWBD) on inhibition of impairment of learning and memory, and acetylcholinesterase in amnesia mice. J. Orient. Neuropsychiatry 13: 149-171.
Choi, K. W. and Jung, I. C. (2008) The effects of Chenwhangbosindan (CBD) hot water extract & ultra-fine powder on the Alzheimer's disease model. J. Orient. Neuropsychiatry 19: 77-93.
Jung, I. C. (2008) Effects of Chenwhangbosim-dan and Sungimjihwang-tang on protecting microglia and inhibiting acetylcholinesterase and oxidants. Korean J. Orient. Physiol. Pathol. 22: 120-125.
Park, J. H., Bae, C. W., Jun, H. S., Hong, S.Y. and Park, S. D. (2004) Antidepressant effect of chunwangboshimdan and its influence on monoamines. Korena J. Orient. Med. Prescrip. 12: 77-93.
Han, S. H., Jeong, S. H., Jeog, S. H., Shin, G. C. and Lee, W. C. (2002) Treated one case of neurogenic heart disease patient with Chunwangbosim-dan (天王補心丹). Korea J. Joongpoong 3: 75-80.
Kim, N. J., Jung, E. A., Kim, H. J., Sim, S. B. and Kim, J. W. (2000) Quality evaluation of various dried roots of Rehmannia glutinosa. Kor. J. Pharmacogn. 31: 130-141.
Ma, B. L., Ma, Y. M., Shi, R., Wang, T. M., Zhang, N., Wang, C. H. and Yang, Y. (2010) Identification of the toxic constituents in Rhizoma Coptidis. J. Ethnopharmacol. 128: 357-364.
Liao, J. F., Huang, S. Y., Jan, Y. M., Yu, L. L. and Chen, C. F. (1998) Central inhibitory effects of water extract of Acori Graminei Rhizoma in mice. J. Ethnopharmacol. 61: 185-193.
Shan, S. M., Luo, J. G., Huang, F. and Kong, L. Y. (2014) Chemical characteristics combined with bioactivity for comprehensive evaluation of Panax ginseng C.A.Meyer in different ages and seasons based on HPLC-DAD and chemometric methods. J. Pharm. Biomed. Anal. 89: 76-82.
Ahn, M. J., Lee, M. K., Kim, Y. C. and Sung, S. H. (2008) The simultaneous determination of coumarins in Angelica gigas root by high performance liquid chromatography-diode array detector coupled with electrospray ionization/mass spectrometry. J. Pharm. Biomed. Anal. 46: 258-266.
Koo, D. C., Suh, W. S., Baek, S. Y. and Shim, S. H. (2011) Quantitative determination of lignans from Schizandra chinensis by HPLC. Kor. J. Pharmacogn. 42: 233-239.
Kwak, H. M., Kim, J. Y., Lim, J. H., Chung, S. K., Kwon, S. H., Jeong, H. H., Hur, J. M. and Song, K. S. (2005) Changes in chemical composition and biological activities of oriental crude drugs by food processing techniques III - Changes of HMF contents from roasted Asparagi Tuber. Kor. J. Pharmacogn. 36: 235-239.
Song, H. Y., Kim, J. K., Hong, S. H., Gwang, C. Y. and Kim, N. K. (2004) Increasing effect of myricetin of Biotae Semen & Biotae Orientalis Folium on the melanogenesis. Korean J. Orient. Physiol. Pathol. 18: 830-836.
Niu, C. and Zhang, J. (2011) Quantitative analysis and chromatographic fingerprinting of the Semen Zizyphi Spinosae by ultra-high-performance liquid chromatography coupled with diode-array detector. J. Sep. Sci. 34: 2989-2996.
Lee, H. W., Park, S. Y., Choo, B. K., Chun, J. M., Lee, A. Y. and Kim, H. K. (2007) Quantitative analysis comparison of Korea and China Scrophulariae Radix. Kor. J. Pharmacogn. 38: 15-18.
Zhang, H. Y., Kim, G. J., Hwang, I. H., Cho, H. J., Lee, S. H. and Na, M. K. (2011) Comparison of the Scrophulariae Radix of Gyeongbuk's with that of Chinese: Content of harpagoside and inhibitory effect of nitric oxide. Kor. J. Pharmacogn. 42: 15-21.
Hoang, L., Kwon, S. H., Kim, K. A., Hur, J. M., Kang, Y. H. and Song, K. S. (2005) Chemical standardization of Poria cocos. Kor. J. Pharmacogn. 36: 177-185.
Fang, Z., Moon, D. C., Son, K. H., Son, J. K., Min, B. S. and Woo, M. H. (2010) Quantitative analyses for the quality evaluation of Salviae Miltiorrhizae Radix by HPLC. Nat. Prod. Sci. 16: 251-258.
Kim, T. J., Lee, S. I., Lee, T. H. and Ko, J. S. (1990) Isolation and determination of platycodin D from Platycodi Radix. Anal. Sci. Technol. 3: 399-404.
Kawashima, K., Miyako, D., Ishino, Y., Makino, T., Saito, K. and Kano, Y. (2004) Anti-stress effects of 3,4,5-trimethoxycinnamic acid, an active constituent of roots of Polygala tenuifolia (Onji). Biol. Pharm. Bull. 27: 1317-1319.
Hong, J. L., Qin, X. Y., Shu, P., Wu, G., Wang, Q. and Qin, M. J. (2010) Analysis of catalpol derivatives by characteristic neutral losses using liquid chromatography combined with electrospray ionization multistage and time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 24: 2680-2686.
Zhao, J., Su, C., Yang, C., Liu, M., Tang, L., Su, W. and Liu, Z. (2012) Determination of ginsenosides Rb1, Rb2, and Rb3 in rat plasma by a rapid and sensitive liquid chromatography tandem mass spectrometry method: Application in a pharmacokinetic study. J. Pharm. Biomed. Anal. 64-65: 94-97.
Wu, Q., Yuan, Q., Liu, E. H., Qi, L. W., Bi, Z. M. and Li, P. (2010) Fragmentation study of iridoid glycosides and phenylpropanoid glycosides in Radix Scrophulariae by rapid resolution liquid chromatography with diode-array detection and electrospray ionization time-of-flight mass spectrometry. Biomed. Chromatogr. 24: 808-819.
Ye, J., Zhang, X., Dai, W., Yan, S., Huang, H., Liang, X., Li, Y. and Zhang, W. (2009) Chemical fingerprinting of Liuwei Dihuang Pill and simultaneous determination of its major bioactive constituents by HPLC coupled with multiple detections of DAD, ELSD and ESI-MS. J. Pharm. Biomed. Anal. 49: 638-645.
Ren, Y., Wang, P., Wu, C., Zhang, J. and Niu, C. (2013) Identification of the metabolites after oral administration of extract of ziziphi spinosae semen to rats or dogs by high-performance liquid chromatography/linear ion trap FTICR hybrid mass spectrometry. Biomed. Chromatogr. 27: 17-26.
Kim, M. K., Yang, D. H., Jung, M., Jung, E. H., Eom, H. Y., Suh, J. H., Min, J. W., Kim, U., Min, H., Kim, J. and Han, S. B. (2011) Simultaneous determination of chromones and coumarins in Radix Saposhnikoviae by high performance liquid chromatography with diode array and tandem mass detectors. J. Chromatogr. A. 1218: 6319-6330.
Rak, G., Fodor, P. and Abranko, L. (2010) Three-step HPLC.ESI-MS/MS procedure for screening and identifying non-target flavonoid derivatives. Int. J. Mass Spectrom. 290: 32-38.
Ma, Y. L., Li, Q. M., Heuvel, V. and Claeys, M. (1997) Characterization of flavone and flavonol aglycones by collision-induced dissociation tandem mass spectrometry. Rapid Commun. Mass Spectrom. 11: 1357-1364.
Liu, A. H., Guo, H., Ye, M., Lin, Y. H., Sun, J. H., Xu, M. and Guo, D. A. (2007) Detection, characterization and identification of phenolic acids in Danshen using high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry. J. Chromatog. A. 1161: 170-182.
Na, Y. C., Ha, Y. W., Kim, Y. S. and Kim, K. J. (2008) Structural analysis of platycosides in Platycodi Radix by liquid chromatography/electrospray ionization-tandem mass spectrometry. J. Chromatogr. A. 1189: 467-475.
Jaiswal, R., Matei, M. F., Ullrich, F. and Kuhnert, N. (2011) How to distinguish between cinnamoylshikimate esters and chlorogenic acid lactones by liquid chromatography-tandem mass spectrometry. J. Mass Spectrom. 46: 933-942.
Gardana, C., Scaglianti, M., Pietta, P. and Simonetti, P. (2007) Analysis of the polyphenolic fraction of propolis from different sources by liquid chromatography-tandem mass spectrometry. J. Pharm. Biomed. Anal. 45: 390-399.
Chang, Y. W., Yao, H. T., Chien, D. S. and Yeh, T. K. (2008) High-performance liquid chromatography-electrospray mass spectrometry for the simultaneous determination of multiple active components in Sheng-Mai San, a prescription of traditional Chinese medicine. Phytochem. Anal. 19: 258-265.
Colas, C., Garcia, P., Popot, M. A., Bonnaire, Y. and Bouchonnet, S. (2006) Liquid chromatography/electrospray ionization mass spectrometric characterization of Harpagophytum in equine urine and plasma. Rapid Commun. Mass Spectrom. 20: 3257-3266.
Zhao, J., Su, C., Yang, C., Liu, M., Tang, L., Su, W. and Liu, Z. (2012) Determination of ginsenosides $Rb_1$ , $Rb_2$ , and $Rb_3$ in rat plasma by a rapid and sensitive liquid chromatography tandem mass spectrometry method: Application in a pharmacokinetic study. J. Pharm. Biomed. Anal. 64-65: 94-97.
Deng, C., Lin, S., Huang, T., Duan, G. and Zhang, X. (2006) Development of gas chromatography/mass spectrometry following headspace solid-phase microextraction for fast determination of asarones in plasma. Rapid Commun. Mass Spectrom. 20: 2120-2126.
Li, P., Wang, G. J., Li, J., Hao, H. P. and Zheng, C. N. (2006) Identification of tanshinone IIA metabolites in rat liver microsomes by liquid chromatography-tandem mass spectrometry. J. Chromatogr. A. 1104: 366-369.
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.