[논문]애완토끼에서 토끼매독의 혈청학적 발생율 및 피부병변 치료

권선정; 김상훈; 박형진; 서경원; 송근호

doi:10.17555/ksvc.2014.02.31.1.15

초록
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본 연구는 국내 애완용 토끼 총 122두를 대상으로 피부병변을 일으키는 토끼매독(Treponema paraluiscuniculi) 감염율을 혈청학적 방법으로 조사하고 피부병변 부위를 알아보기 위해 실시하였다. 혈청학적 감염율은 21.3%이었으며 수컷보다는 암컷이, 1세 이상보다는 1세 미만에서 유의성 있는 높은 감염율을 나타내었다(각각 p < 0.01). 피부병변은 입술(59.1%), 코(56.5%), 생식기(50.0%), 항문(40.9%) 및 눈꺼풀(18.2%) 순으로 나타났다. 혼합병변은 코와 입술(26.0%), 항문과 생식기(21.8%), 입술, 항문 및 생식기(17.4%) 순으로 나타났다. 모든 피부병변은 Penicillin G(48,000-84,000 IU/kg, 녹십자, 한국)로 1주일 간격으로 3-4회 치료 후 완치 되었다. 피부 병변을 가지고 있거나, 토끼매독의 혈청학적 양성을 나타내는 환자의 경우 즉각적인 치료 및 교배에서 배제가 필요하다.

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A total of 122 rabbits (40 males, 51 females, 25 castrated males and 6 spayed females; age range: 3 months to 11 years; weight range: 0.8-3.4 kg) were admitted to Veterinary Medical Teaching Hospital of Chungnam National University from January 2012 to February 2013. The syphilis rapid test was posi...

A total of 122 rabbits (40 males, 51 females, 25 castrated males and 6 spayed females; age range: 3 months to 11 years; weight range: 0.8-3.4 kg) were admitted to Veterinary Medical Teaching Hospital of Chungnam National University from January 2012 to February 2013. The syphilis rapid test was positive in 21.3% of rabbits, with a significant difference in the rates of positivity between male versus female rabbits and rabbits younger than 1 year versus older than 1 year of age (both p < 0.01). Skin lesions were detected around the lips (59.1%), nose (56.5%), genitalia (50.0%), anus (40.9%) and eyelids (18.2%). Coexisting skin lesions were found on the nose and lips (26.0%); anus and genitalia (21.8%); lips, anus and genitalia (17.4%) of rabbits. Twenty-two rabbits with skin lesions were subcutaneously treated with Penicillin G (48,000-84,000 IU/kg, Green cross, Korea) every 7 days for three or four weeks. All skin lesions were disappeared after Penicillin G treatment. In conclusion, a rabbits with skin lesions and serological test positive for syphilis should undergo prompt treatment and not be used for breeding.

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palladium antigen, the Venereal Disease Research Laboratory (VDRL), rapid plasma reagin (RPR), and fluorescent treponemal antibody-absorption (FTA-ABS) test (1,3,4,6,7). The aim of this study was to survey the seroprevalence of rabbit syphilis and treat the syphilis-associated skin lesions in pet rabbits in Korea.

제안 방법

Serum samples were tested using the Asan Easy test Syphilis® (Asan Pharmaceutical, Seoul, South Korea), an immunochromatographic test for the detection of human syphilis-specific antibody.
In our study, only four out of 26 serologically positive rabbits were healthy and without skin lesions. Twenty-two rabbits with skin lesions were subcutaneously treated with Penicillin G (48,000-84,000 IU/kg, Green cross, South Korea) every 7 days for three or four weeks. All skin lesions were disappeared after Penicillin G treatment.

대상 데이터

A total of 122 rabbits (40 males, 51 females, 25 castrated males and 6 spayed females; age: 3 months to 11 years; weight: 0.8-3.4 kg) were studied from January 2012 to February 2013. Breeds were included as follows; Lion-head (29 head), New Zealand White (27 head), mongrel (27 head), Giant (23 head), Dutch (7 head), Dwarf (3 head), Rex (3 head) and Lop ear (1 head).
4 kg) were studied from January 2012 to February 2013. Breeds were included as follows; Lion-head (29 head), New Zealand White (27 head), mongrel (27 head), Giant (23 head), Dutch (7 head), Dwarf (3 head), Rex (3 head) and Lop ear (1 head). The rabbits were privately raised by 122 individual owners in owner’s house, and didn’t live together from the other rabbits.
All rabbits were raised by feeding of hay and pellet, and they lived freely in owner’s house and did not have experience of mating. This study was performed with the consent of the 122 individual owners.

데이터처리

If a significant association (p < 0.05) was detected, a pair-wise comparison was performed with the 1 Mann-Whitney U-test.

성능/효과

In this study, the seroprevalence of rabbit syphilis was found to be 21.3% by the rapid syphilis test. The use of rapid syphilis tests has been proven to be a suitable replacement for the traditional syphilis serology diagnosis approach in human medicine (1,7).

참고문헌 (12)

Bronzan RN, Mwesigwa-Kayongo DC, Narkunas D, Scmid GP, Neilsen GA, Ballard RC, Karuhije P, Ddamba J, Nombekela E, Hoyi G, Dlai P, Makwedini N, Fehler HG, Blandford JM, Ruan C. On-site rapid antenatal syphilis screening with an immunochromatographic strip improves case detection and treatment in rural South African clinics. Sex Transm Dis 2007; 34: 55-60.

상세보기
Cunliffe-Beamer TL, Fox RR. Venereal spirochetosis of rabbits: description and diagnosis. Lab Anim Sci 1981; 31: 366-371.

상세보기
DiGiacomo RF, Lukehart SA, Talburt CD, Baker-Zander SA, Giddens WE Jr, Condon J, Broun CW. Chronicity of infection with Treponema paraluis-cuniculi in New Zealand white rabbits. Genitourin Med 1985; 61: 156-164.

상세보기
DiGiacomo RF, Talburt CD, Lukehart SA, Baker-Zander SA, Condon J. Treponema paraluis-cuniculi infection in a commercial rabbitry: epidemiology and serodiagnosis. Lab Anim Sci 1983; 33: 562-566.

상세보기
Harcourt-Brown F. Skin diseases. In: Textbook of rabbit medicine. Oxford: Reed Educational and Professional Publishing Ltd. 2002: 224-248.
Harkness JE, Wagner JE. Specific disease and conditions. In: The biology and medicine of rabbits and rodents. Philadelphia: Williams and Wilkins. 1995: 315-316.
Juarez-Figueroa L, Uribe-Salas F, Garcia-Cisneros S, Olamendi-Portugal M, Conde-Glez CJ. Evaluation of a rapid strip and a particle agglutination tests for syphilis diagnosis. Diagn Microbiol Infect Dis 2007; 59: 123-126.

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Kim SH, Lee SE, Song KH, Kim DH. Dermatitis associated with treponematosis in pet rabbits. J Vet Clin 2009; 26: 625-627.
Saito K, Hasegawa A. Clinical features of skin lesions in rabbit syphilis: a retrospective study of 63 cases (1999-2003). J Vet Med Sci 2004; 66: 1247-1249.

상세보기
Saito K, Tagawa M, Hasegawa A. RPR test for serological survey of rabbit syphilis in companion rabbits. J Vet Med Sci 2003; 65: 797-799.

상세보기
Saunders RA, Davies RR. Infectious diseases. In: Notes on rabbit internal medicine. Oxford: Blackwell Publishing. 2005: 175-198.
Paterson S. Skin diseases and treatments of rabbits. In: Skin diseases of exotic pets. Oxford: Blackwell Science Ltd. 2006: 288-311.

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애완토끼에서 토끼매독의 혈청학적 발생율 및 피부병변 치료
Seroprevalence and Treatment for Skin Lesions of Rabbit Syphilis in Pet Rabbits 원문보기

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애완토끼에서 토끼매독의 혈청학적 발생율 및 피부병변 치료 Seroprevalence and Treatment for Skin Lesions of Rabbit Syphilis in Pet Rabbits 원문보기

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애완토끼에서 토끼매독의 혈청학적 발생율 및 피부병변 치료
Seroprevalence and Treatment for Skin Lesions of Rabbit Syphilis in Pet Rabbits 원문보기

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