전립선암 방사선치료 시 광자극발광선량계를 이용한 광중성자선량 평가 Evaluation of Photoneutron Dose for Prostate Cancer Radiation Therapy by Using Optically Stimulated Luminescence Dosimeter (OSLD)원문보기
본 연구는 전립선암의 방사선치료에 적용되는 치료기법별 세기조절방사선치료의 적절한 조사문수의 선택 및 광중성자 피폭을 고려한 방사선 치료계획 수립을 위한 기초자료를 제공하고자 하였다. 연구대상은 2013년 9월부터 2014년 1월까지 5개월 동안 전립선암으로 방사선치료를 받은 환자 10명을 대상으로 하였다. 그리고 3-dimensional conformal radiotherapy (3D-CRT), volumetric-modulated arc radiotherapy (VMAT), intensity modulated radiation therapy (IMRT) 5, 7, 9 조사문으로 각각 치료계획을 수립하였다. 기술통계와 분산분석으로 광중성자선량의 평균적 차이를 비교하였으며, 상관관계분석과 회귀분석으로 상관성 및 영향을 분석하였다. 연구 결과, 치료기법별로는 3D-CRT가 가장 낮았다. 또한 IMRT가 가장 높게 측정되었으며, 통계적으로 매우 유의하였다 (p<.01). 세기조절방사선치료 조사문수별 광중성자선량은 평균 $4.37{\pm}1.08mSv$였으며, 조사문수 간에 통계적으로 매우 유의한 차이를 보였다(p<.01). 그리고 조사문수와 광중성자선량은 상관계수가 0.570으로 나타나 통계적으로 매우 유의한 양의 상관관계를 보였다 (p<.01). 조사문수와 광중성자선량의 선형회귀분석 결과, 조사문수가 1단계 증가할 때마다 평균적으로 광중성자선량이 0.373배로 유의하게 증가하였다. 결론적으로 전립선암의 방사선치료에 빈번히 사용하고 있는 IMRT의 조사문수의 선택 및 광중성자 피폭선량 및 방사선 치료계획의 질적 수준 평가를 고려한 적절한 치료계획 선택에 있어 기초자료로 활용될 수 있으리라 기대된다.
본 연구는 전립선암의 방사선치료에 적용되는 치료기법별 세기조절방사선치료의 적절한 조사문수의 선택 및 광중성자 피폭을 고려한 방사선 치료계획 수립을 위한 기초자료를 제공하고자 하였다. 연구대상은 2013년 9월부터 2014년 1월까지 5개월 동안 전립선암으로 방사선치료를 받은 환자 10명을 대상으로 하였다. 그리고 3-dimensional conformal radiotherapy (3D-CRT), volumetric-modulated arc radiotherapy (VMAT), intensity modulated radiation therapy (IMRT) 5, 7, 9 조사문으로 각각 치료계획을 수립하였다. 기술통계와 분산분석으로 광중성자선량의 평균적 차이를 비교하였으며, 상관관계분석과 회귀분석으로 상관성 및 영향을 분석하였다. 연구 결과, 치료기법별로는 3D-CRT가 가장 낮았다. 또한 IMRT가 가장 높게 측정되었으며, 통계적으로 매우 유의하였다 (p<.01). 세기조절방사선치료 조사문수별 광중성자선량은 평균 $4.37{\pm}1.08mSv$였으며, 조사문수 간에 통계적으로 매우 유의한 차이를 보였다(p<.01). 그리고 조사문수와 광중성자선량은 상관계수가 0.570으로 나타나 통계적으로 매우 유의한 양의 상관관계를 보였다 (p<.01). 조사문수와 광중성자선량의 선형회귀분석 결과, 조사문수가 1단계 증가할 때마다 평균적으로 광중성자선량이 0.373배로 유의하게 증가하였다. 결론적으로 전립선암의 방사선치료에 빈번히 사용하고 있는 IMRT의 조사문수의 선택 및 광중성자 피폭선량 및 방사선 치료계획의 질적 수준 평가를 고려한 적절한 치료계획 선택에 있어 기초자료로 활용될 수 있으리라 기대된다.
This study is to provide basic information regarding photoneutron doses in terms of radiation treatment techniques and the number of portals in intensity-modulated radiation therapy (IMRT) by measuring the photoneutron doses. Subjects of experiment were 10 patients who were diagnosed with prostate c...
This study is to provide basic information regarding photoneutron doses in terms of radiation treatment techniques and the number of portals in intensity-modulated radiation therapy (IMRT) by measuring the photoneutron doses. Subjects of experiment were 10 patients who were diagnosed with prostate cancer and have received radiation treatment for 5 months from September 2013 to January 2014 in the department of radiation oncology in S hospital located in Seoul. Thus, radiation treatment plans were created for 3-Dimensional Conformal Radiotherapy (3D-CRT), Volumetric-Modulated Arc Radiotherapy (VMAT), IMRT 5, 7, and 9 portals. The average difference of photoneutron dose was compared through descriptive statistics and variance analysis, and analyzed influence factors through correlation analysis and regression analysis. In summarized results, 3D-CRT showed the lowest average photoneutron dose, while IMRT caused the highest dose with statistically significance (p <.01). The photoneutron dose by number of portals of IMRT was $4.37{\pm}1.08mSv$ in average and statistically showed very significant difference among the number of portals (p <.01). Number of portals and photoneutron dose are shown that the correlation coefficient is 0.570, highly statistically significant positive correlation (p <.01). As a result of the linear regression analysis of number of portals and photoneutron dose, it showed that photoneutron dose significantly increased by 0.373 times in average as the number of portals increased by 1 stage. In conclusion, this study can be expected to be used as a quantitative basic data to select an appropriate IMRT plans regarding photoneutron dose in radiation treatment for prostate cancer.
This study is to provide basic information regarding photoneutron doses in terms of radiation treatment techniques and the number of portals in intensity-modulated radiation therapy (IMRT) by measuring the photoneutron doses. Subjects of experiment were 10 patients who were diagnosed with prostate cancer and have received radiation treatment for 5 months from September 2013 to January 2014 in the department of radiation oncology in S hospital located in Seoul. Thus, radiation treatment plans were created for 3-Dimensional Conformal Radiotherapy (3D-CRT), Volumetric-Modulated Arc Radiotherapy (VMAT), IMRT 5, 7, and 9 portals. The average difference of photoneutron dose was compared through descriptive statistics and variance analysis, and analyzed influence factors through correlation analysis and regression analysis. In summarized results, 3D-CRT showed the lowest average photoneutron dose, while IMRT caused the highest dose with statistically significance (p <.01). The photoneutron dose by number of portals of IMRT was $4.37{\pm}1.08mSv$ in average and statistically showed very significant difference among the number of portals (p <.01). Number of portals and photoneutron dose are shown that the correlation coefficient is 0.570, highly statistically significant positive correlation (p <.01). As a result of the linear regression analysis of number of portals and photoneutron dose, it showed that photoneutron dose significantly increased by 0.373 times in average as the number of portals increased by 1 stage. In conclusion, this study can be expected to be used as a quantitative basic data to select an appropriate IMRT plans regarding photoneutron dose in radiation treatment for prostate cancer.
Sae-Chul Kim: A continuous increase in prevalence of prostate cancer in Korea and its Ccauses. Journal of the Korean Medical Association, 47(5), 394-402, 2004
Pollack A, Zagars GK, Starkschall G, et al : Prostate cancer radiation dose response: results of the M. D. Anderson phase III randomized trial. Int J Radiat Oncol Biol Phys, 53(5), 1097-1105, 2002
Bo-Kyoung Kim, Suk Won Park, Sung Whan Ha, et al : Pattern of decrease of prostate specific antigen after radical radiotherapy for the prostate cancer. The Journal of the Korean Society for therapeutic radiology and oncology, 17(2), 136-40, 1999
Pasteau, Octave : Traitement du cancer de la prostate par le radium. Rev de Mal de la Nutriion, 363, 1911
John R, Caulk : Carcinoma of the prostate. The American Journal of Cancer, 16, 1024-52, 1932
Flocks RH : Interstitial irradiation therapy with a solution of Au-198 as part of combination therapy for prostatic carcinoma. J Nucl Med, 5, 691-705, 1964
Chul-Whan Hwang : The dosimetric influence of rotational errors during radiation therapy for prostate cancer. Catholic University of Pusan, 2014
Michael J, Zelefsky, Zvi Fuks, et al : Highdose intensity modulated radiation therapy for prostate cancer : early toxicity and biochemical outcome in 772 patients. Int J Radiat Oncol Biol Phys, 53, 1111-6, 2002
Sung-Kyu Kim, Myung-Se Kim, Sang-Mo Yun, et al : Dose distribution of intensity modulated radiation therapy and 3 dimensional conformal radiation therapy in prostate cancer. Yeungnam University J of Med, 24(2), 538-43, 2007
Erjona B, Ervis T, Elvisa K : Comparison of 3D CRT and IMRT tratment plans. Acta Inform Med, 21(3), 211-2, 2013
Hae-Sook Kim, Jin-Kyung Jang, Hyun-soon Sohn, et al : Anticancer drug use and out-ofpocket money burden in Korean cancer patients. Korean journal of clinical pharmacy, 22(3), 239-50, 2012
Rebecca MH, Michele SF, Nolan El, et al : Investigation of secondary neutron dose for 18 MV dynamic MLC IMRT delivery. Medical Physics, 32(3), 786, 2005
Oh-Nam Yang, Cheong-Whan Lim : Study on the photoneutrons produced in 15 MV medical linear accelerators. Korean society of radiological science, 35(4), 335-43, 2012
I Gudowska, A Brahme, P Andreo, et al : Calculation of absorbed dose and biological effectiveness from photonuclear reactions in a bremsstrahlung beam of end point 50 MeV. Phys Med Biol, 44(9), 2099-125, 1999
Dietze G, Siebert BR : Photon and neutron dose contributions and mean quality factors phantoms of different size irradiated by monoenergetic neutrons. Radiat Res, 140(1), 130-3, 1994
Jung-Suk Shin, Young-Yih Han, Sang-Gyu Ju, et al : Analysis of the imaging dose for IGRT gated treatments. The Korean Society for Radiation Oncology, 27(1), 42-48, 2009
Jursinic PA : Changes in optically stimulated luminescent dosimeter (OSLD) dosimetric characteristics with accumulated dose. Med Phys, 37(1), 132-40, 2010
Jeong-Ho Kim : Selection of reduction techniques of artifact at radiation treatment. Chonbuk National University, 2013
Jursinic PA : Characterization of optically stimulated luminescent dosimeters, OSLDs, for clinical dosimetric measurements. Med Phys, 34(12), 4594-604, 2007
Hye-li Park, Sei-Kyung Chang, Ja-young Kim, et al :Permanent brachytherapy of localized prostate cancer preliminary results. The Korean Society for Radiation Oncology, 29(2), 71-82, 2011
Levinger JS, Bethe HA : Neutron yield from the nuclear photo effect. Phys Rev, 5, 221-2, 1952
Hall EJ, Wuu CS : Radiation-induced second cancers : the impact of 3D-CRT and IMRT. Int J Radiat Oncol Biol Phys, 56, 83-88, 2003
Cheol-Soo Park : A study on the neutron dose distribution in case of 10 MV X-rays radiotherapy. Korean society of radiological science, 31(4), 415-27, 2008
A Zanini, C Durisi, F Fasolo, et al : Monte carlo simulation of the photoneutron field in linac radiotherapy treatments with different collimator systems. Phys. Med. Biol, 49, 571-82, 2004
D'Errico F, Nath R, Silvano Gr, et al : In vivo neutron dosimetry during high-energy bremsstrahlung radiotherapy. Int J Radiat Oncol Biol Phys, 41(5), 1185-92, 1998
Rivera JC, Falcao RC, deAlmeida CE : The measurement of photoneutron dose in the vicinity of clinical linear accelerators. Radiat Prot Dosimetry, 130, 403-9, 2008
※ AI-Helper는 부적절한 답변을 할 수 있습니다.