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NTIS 바로가기한국산업위생학회지 = Journal of Korean Society of Occupational and environmental hygiene, v.24 no.3, 2014년, pp.310 - 320
이경민 (근로복지공단 직업성폐질환연구소) , 염정관 (한불에너지관리(주)) , 이원재 (가천대학교 헬스케어경영학과) , 류승훈 (고려대학교 환경의학연구소) , 박동진 (안전보건공단 산업안전보건연구원) , 박동욱 (한국방송통신대학교 환경보건학과)
Backgrounds: Endotoxin, which found in the outer membrane of the gram-negative bacteria cell wall, makes up almost all of the lipopolysaccharide(LPS). When people are exposed to endotoxin,it can result in diverse health effects such as an airway irritation and inflammation, fever, malaise, bronchiti...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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엔도톡신은 무엇인가? | 엔도톡신(Endotoxin)은 그람음성박테리아(Gramnegative bacteria, GNB)의 외벽에 붙어 있으며, 지질 A(Lipid A)로 불리는 지질다당류(Lipopolysaccharide) 로서 GNB를 구조적으로 지지(Structural integrity)하고, 생리적(Physiological)․면역적(Immunologic) 기능을 하며, 영양을 운반(Nutrient transport function)하기도 한다(Williams, 2001). | |
엔도톡신 농도에 결정적으로 영향을 미치는 요인은? | 이연구결과에서 계절에 따른 유의한 차이를 확인할 수있었는데, 이때 습도가 온도보다 엔도톡신에 더 높은 연관성이 있는 것으로 나타났다. 따라서 실내 온도와 습도가 엔도톡신에 영향을 미치는 중요한 요인이라 보고하였다. 특히 습도는 다른 연구 결과에서도 엔도톡신 농도 수준에 결정적으로 영향을 미치는 요인으로 보고된 바 있다(Macher et al. | |
낮은 농도의 엔도톡신은 어떠한 질환들을 일으키는가? | 발열(Pyrogen)하는 특징이 있어 호흡 경로를 통해 인체에 노출되면 심각한 질환들을 일으키는데(Rietschel et al., 1993), 낮은 농도의 엔도톡신은 호흡기 점막 자극과 염증(Airway irritation and inflammation), 발열 (Fever), 불쾌함(Malaise), 기관지염(Bronchitis), 알러지성 천식(Allergic asthma), 오한(Chills)을 일으키고, 높은 농도는 독성 폐렴(Toxic pneuminitis), 과민성 폐질환 (Hypersensitivity lung disease), 폐혈증(Sepsis) 등을 일으킬 가능성이 있다고 알려져 있다(Rylander et al., 1989; Loppnow et al. |
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Bouillard L, Michel O, Dramaix M, Devleeschouwer M. Bacterial contamination of indoor air, surfaces, and settled dust, and related dust endotoxin concentrations in healthy office buildings. Ann Agric Environ Med 2005;12:187-192
Cho HJ, Hong KS, Kim JH, Kim HW. Assessment of airborne bioaerosols among different areas in the hospitals. J Korea Soc Occup Environ Hyg 2000; 10(1):115-125
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