경동맥 내중막 두께는 뇌혈관질환과 관상동맥질환을 정밀하게 측정하는 검사이다. 많은 선행논문에 따르면 경동맥 내중막 두께는 죽상동맥경화를 예측하고 심혈관질환의 위험인자와 연관성이 높으며, 심근경색이나 뇌졸중 발생 위험을 예측할 수 있는 독립인자로 연구되었다. 따라서 본 연구는 혈액검사 중 임상화학적 검사결과와의 상관관계 연구를 통해 경동맥 내중막 두께와 다른 독립인자를 확보하는 것이 목적이었다. 연구결과 피험자의 부족으로 인해 심혈관계관련 임상화학적 요인과는 상관관계를 입증하지 못했으나, 경동맥 내중막 두께와 ALT (p<0.05), GGT (p<0.05), Uric acid (p<0.05), CEA (p<0.05)와 양의 상관관계를 통계적인 유의수준으로 입증하여 지속적인 연구의 문제를 제기하였다.
경동맥 내중막 두께는 뇌혈관질환과 관상동맥질환을 정밀하게 측정하는 검사이다. 많은 선행논문에 따르면 경동맥 내중막 두께는 죽상동맥경화를 예측하고 심혈관질환의 위험인자와 연관성이 높으며, 심근경색이나 뇌졸중 발생 위험을 예측할 수 있는 독립인자로 연구되었다. 따라서 본 연구는 혈액검사 중 임상화학적 검사결과와의 상관관계 연구를 통해 경동맥 내중막 두께와 다른 독립인자를 확보하는 것이 목적이었다. 연구결과 피험자의 부족으로 인해 심혈관계관련 임상화학적 요인과는 상관관계를 입증하지 못했으나, 경동맥 내중막 두께와 ALT (p<0.05), GGT (p<0.05), Uric acid (p<0.05), CEA (p<0.05)와 양의 상관관계를 통계적인 유의수준으로 입증하여 지속적인 연구의 문제를 제기하였다.
Carotid Intima-Media Thickness (CIMT) testing is a test that precisely assesses cerebrovascular and coronary heart diseases. According to many previous studies, CIMT predicts atherosclerosis and is highly correlated to cardiovascular disease risk factors. It has also been reported that CIMT is an in...
Carotid Intima-Media Thickness (CIMT) testing is a test that precisely assesses cerebrovascular and coronary heart diseases. According to many previous studies, CIMT predicts atherosclerosis and is highly correlated to cardiovascular disease risk factors. It has also been reported that CIMT is an independent predictor of risk factors for myocardial infarction and stroke. Therefore, the purpose of this study is to investigate CIMT and other independent factors through a correlation study with the clinical laboratory test results of a blood test. As a result, this study could not prove the correlation between CIMT and risk factors of cardiovascular disease (TC, TG, LDL cholesterol, and HDL cholesterol) due to an insufficient number of subjects. Nevertheless, a positive correlation was demonstrated between CIMT and ALT (p<0.05), GGT (p<0.05), Uric acid (p<0.05), and CEA (p<0.05) at a statistically significant level, suggesting a continuation of the study.
Carotid Intima-Media Thickness (CIMT) testing is a test that precisely assesses cerebrovascular and coronary heart diseases. According to many previous studies, CIMT predicts atherosclerosis and is highly correlated to cardiovascular disease risk factors. It has also been reported that CIMT is an independent predictor of risk factors for myocardial infarction and stroke. Therefore, the purpose of this study is to investigate CIMT and other independent factors through a correlation study with the clinical laboratory test results of a blood test. As a result, this study could not prove the correlation between CIMT and risk factors of cardiovascular disease (TC, TG, LDL cholesterol, and HDL cholesterol) due to an insufficient number of subjects. Nevertheless, a positive correlation was demonstrated between CIMT and ALT (p<0.05), GGT (p<0.05), Uric acid (p<0.05), and CEA (p<0.05) at a statistically significant level, suggesting a continuation of the study.
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제안 방법
, Chicago, IL, USA) program. A frequency analysis and mean (M) and standard deviation (SD) were calculated for the physical features, blood test results, and CIMT of the subjects. An independent t-test was performed for homogeneity test, and ANOVA test for the difference, Post-test was used for Dunnett 3 ways and a correlation analysis was performed for relational analysis.
Moreover, South Korea has been providing free health check-ups, including general health check-up, cancer screening, and health check-up for infants based on the Framework Act on Health Examination that was established on March 21st, 2008, to the public after establishing the National Health Insurance Law on December 31st, 1997 (Sung, 2014). Based on this setting, this study aimed to investigate the relationship between the various blood test items that are generally included in the national health check-up category and CIMT by ultrasonography, which is not included in the basic health check-up category.
Blood test was performed by collecting venous blood samples after fasting for more than 8 hours, and Aspartate aminotransferase (AST), Alanine Aminotransferase (ALT), Alkaline phosphatase (ALP), Gamma(γ)-glutamyl transpeptidase (GGT), Total bilirubin (T-Bil), Uric acid, Total Cholesterol (TC), High density lipoprotein cholesterol (HDL), Low density lipoprotein cholesterol (LDL), Triglyceride (TG), Lactate dehydrogenase (LDH), Creatine Phosphokinase (CPK), and carcinoembryonic antigen (CEA) were tested.
CIMT was measured using Accuvix V20 (Medison, South Korea) on 3 parts: the common carotid, the carotid bulb (Bulb), and the area in between the two. Study subjects were facing the left side and laid down comfortably to set the probe around the central part of the sternocleidomastoid, which is below the thyroid cartilage.
CIMT was measured using Accuvix V20 (Medison, South Korea) on 3 parts: the common carotid, the carotid bulb (Bulb), and the area in between the two. Study subjects were facing the left side and laid down comfortably to set the probe around the central part of the sternocleidomastoid, which is below the thyroid cartilage. The probe was manipulated vertically to show the cross section of the vein (internal jugular) and artery (common carotid) on the screen of Accuvix V20 and horizontally for the longitudinal side of the vein and artery.
The purpose of this study was to investigate the correlation between CIMT by the carotid artery ultrasonography and clinical laboratory test, which is part of the blood test item in a physical examination category that is generally being conducted. The clinical laboratory blood test and CIMT test results analyzed in this study was conducted at a large comprehensive health examination center located in Gyeonggido.
대상 데이터
The purpose of this study was to investigate the correlation between CIMT by the carotid artery ultrasonography and clinical laboratory test, which is part of the blood test item in a physical examination category that is generally being conducted. The clinical laboratory blood test and CIMT test results analyzed in this study was conducted at a large comprehensive health examination center located in Gyeonggido. The subjects of this study were 67 healthy adults in the age of 30∼55, with 35 males and 32 females.
The subjects of this study were 67 healthy adults in the age of 30∼55, with 35 males and 32 females.
The total number of subjects who participated in this study is 67 with 35 males and 32 females. The average age of the subjects was 45.
데이터처리
A frequency analysis and mean (M) and standard deviation (SD) were calculated for the physical features, blood test results, and CIMT of the subjects. An independent t-test was performed for homogeneity test, and ANOVA test for the difference, Post-test was used for Dunnett 3 ways and a correlation analysis was performed for relational analysis. All statistical significance level was set as p＜0.
성능/효과
According to an analysis of the correlation between the results from the carotid artery ultrasonography, each variable of the general characteristics of the subjects, and results from the blood test, the results of carotid artery ultrasonography and CIMT showed a positive correlation with general characteristics, where age group showed a positive relationship (p＜0.01). For physical characteristics, height and weight both showed a positive relationship (p＜0.
According to the CIMT test results by age, the 30’s group showed an average of 0.47±0.05 mm, 40’s an average of 0.50± 0.06 mm, and 50’s an average of 0.54±0.06 mm.
Clinical laboratory test result by gender showed a significant difference (p＜0.01) between 31.57±14.18 IU in the male group and 19.72±5.68 IU in the female group, with the male group displaying a higher average value.
In conclusion, this study investigated the correlation between CIMT and clinical laboratory test results, in addition to the relationship between CIMT and blood pressure and cardiovascular risk factors that was previously studies. Results of this study showed that CIMT has a positive correlation with ALT (p＜0.
The average total CIMT was 0.51±0.06 mm, and males and females showed a statistically significant difference (p＜0.01), where males showed an average of 0.06 mm thicker CIMT than females with an average of 0.53±0.54 mm in males and 0.47±0.65 mm in females.
후속연구
In conclusion, this study investigated the correlation between CIMT and clinical laboratory test results, in addition to the relationship between CIMT and blood pressure and cardiovascular risk factors that was previously studies. Results of this study showed that CIMT has a positive correlation with ALT (p＜0.05), GGT (p＜0.05), Uric acid (p＜ 0.05), and CEA (p＜0.05), and therefore further studies should be considered for continuous investigation.
참고문헌 (12)
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