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NTIS 바로가기大韓本草學會誌 = The Korea journal of herbology, v.30 no.1, 2015년, pp.77 - 84
이흥기 (가천대학교 한의과대학 해부경혈학교실) , 김도훈 (가천대학교 한의과대학 원전의사학교실) , 김연섭 (가천대학교 한의과대학 해부경혈학교실)
Objectives : Brain inflammation early activates the microglia and activated microglia secrete a variety of pro-inflammatory cytokines. Kaempferol, which is a flavonoid in Cuscutae Semen, shows a wide range of physiological activities, including neurons protection and anti-inflammatory actions throug...
핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
Kaempferol(3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one)이란 무엇인가? | Kaempferol (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one)은 馬牙木屬7), 紅花8), 靑黛9), 山養蔘10), 菟絲子11) 등에 함유되어 있는 플라보노이드 성분중 하나이다. Kaempferol의 실험적 연구에서 알레르기성 천식 생쥐12), lipopolysaccharide (LPS)로 유도된 유선염 생쥐13), 덱스트란 황산나트륨으로 유도된 궤양성 대장염 생쥐14) 및 카라기난을 이용한 air pouch model 쥐에서15) 항염증 효과가 있다고 보고되었다. | |
중추신경계의 염증은 어떻게 시작되는가? | 중추신경계의 염증은 침윤 주변 대식세포와 림프구뿐만 아니라 상주 미세아교세포와 성상세포의 활성화에 의해 시작된다. 활성화된 미세아교세포 등은 싸이토카인, 케모카인, 신경전달물질 및 활성 산소종을 과잉 분비한다1). | |
중추신경계 염증은 어떠한 질환이나 발병과 강한 관련성이 있는가? | 미세아교세포의 활성과 BBB의 붕괴로 매개된 중추신경계 염증은 신경세포 사멸과 허혈 재관류 손상에서 경색영역 (infarct area) 확산에 기여하는 중요한 요소이다3). 그리고 미세아교세포로 인한 중추신경염증은 뇌 허혈, 알츠하이머병, 파킨슨병, 헌팅턴병 및 루게릭병과 같은 신경퇴행성 질환 및 다양한 신경학적 발병과 강한 관련성이 있다고 한다4-6). |
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