[논문]비글견에서 아이소플루란/레미펜타닐 및 아이소플루란/펜타닐 조합의 마취 효과

박지영; 오승준; 이해범; 정성목

doi:10.17555/jvc.2015.04.32.2.148

비글견에서 아이소플루란/레미펜타닐 및 아이소플루란/펜타닐 조합의 마취 효과
Effects of Isoflurane/Remifentanil and Isoflurane/Fentanyl Anesthesia in Beagle Dogs 원문보기

Journal of veterinary clinics = 한국임상수의학회지, v.32 no.2, 2015년, pp.148 - 153

박지영 (충남대학교 수의과대학.동물의과학 연구소) , 오승준 (충남대학교 수의과대학.동물의과학 연구소) , 이해범 (충남대학교 수의과대학.동물의과학 연구소) , 정성목 (충남대학교 수의과대학.동물의과학 연구소)

초록
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본 연구는 비글견에서의 마취 효과에 있어서 isoflurane과 병용시에 두가지 opioid 약물을 비교, 아이소플루란/레미펜타닐과 아이소플루란/펜타닐 조합의 마취간의 차이를 알아보기 위하여 실시하였다. Isoflurane은 0.5 MAC으로 유지하고, opioid 약물은 등속으로 정맥 주입하였다. 각 개체에서 마취를 2시간 동안 유지한 뒤, isoflurane과 opioid 약물을 중단하고서 안구가 제 위치를 찾는 시간(eye global positioning time), 연하 반사가 나타나는 시간(gag reflex time), 머리를 드는 시간(head up time), 엎드림 자세가 나타나는 시간(sternal recumbency time), 서는 시간(standing time), 걷는 시간(walking time), 그리고 마취에서 완전히 회복된 시간(complete recovery time)을 기록하였다. 두가지 조합 모두 전 과정에 걸쳐 양호한 마취상태를 유지함과 동시에 빠를 회복 시간을 보여 비글견의 마취에 적합하였다. 한편, 회복 시간에 있어 아이소플루란/레미펜타닐 조합은 아이소플루란/펜타닐 조합에 비해 그 변동 계수가 낮아 좀 더 신뢰할 만한 것으로 나타났다. 따라서, 환자의 중등도가 높고, 안정적인 회복이 요구될 때에는 아이소플루란/레미펜타닐 조합의 마취가 더 좋은 선택일 것으로 생각된다.

Abstract ▼ AI-Helper

This study was performed to compare two opioid drugs with isoflurane and to determine the difference between isoflurane/remifentanil anesthesia and isoflurane/fentanyl anesthesia in terms of the anesthetic effects in beagle dogs. Isoflurane was maintained at 0.5 MAC, and the opioid drug was administered as a constant rate infusion. The anesthesia was maintained for 2 hours, and isoflurane and opioid drugs were discontinued 2 hours later. After discontinuing the anesthetics, the extremity movement time, eye global positioning time, gag reflex time, head up time, sternal recumbency time, standing time, walking time and complete recovery times were recorded for each dog. Both of the studied anesthetic protocols were suitable in beagle dogs because the anesthetic status was well maintained until the end of the procedure, and rapid recovery times were demonstrated in this experiment. And this study shows that the isoflurane/remifentanil group was more reliable than the isoflurane/fentanyl group because the recovery time CV was lower. Therefore, isoflurane/remifentanil combination anesthesia could be a better choice than isoflurane/fentanyl anesthesia if the patient is severely ill and stable recovery time is needed.

주제어

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문제 정의

The aim of this study was to compare these two opioid drugs with isoflurane and to determine the difference between isoflurane/remifentanil anesthesia and isoflurane/fentanyl anesthesia in terms of the anesthetic effects in beagle dogs.

제안 방법

After discontinuing the anesthetics, the extremity movement time, eye global positioning time, gag reflex time, head up time, sternal recumbency time, standing time, walking time and complete recovery times were recorded for each dog. Extremity movement time is the time period before which the dog tries to move his or her extremities.
Cardiovascular parameters were measured and recorded at time 0 (before the drug injections) and every 20 minutes for 2 hours after the administration of the opioids. The heart rate (HR) and blood pressure (BP) [systolic arterial pressure (SAP), mean arterial pressure (MAP), and diastolic arterial pressure (DAP)] were measured using the anesthesia monitor.
Arterial blood gas analysis was performed with a portable arterial blood gas analyzer. In this experiment, arterial oxygen partial pressure (PaO₂), carbon dioxide partial pressure (PaCO₂), bicarbonate (HCO₃), arterial oxygen saturation (SaO₂), total carbon dioxide (TCO₂), and arterial pH were measured.

대상 데이터

Eight healthy beagle dogs with an average weight of 7.83 ± 1.77 kg (female: 4, male: 4) were used.

데이터처리

Differences in the physiological parameters within the group were tested with one-way analysis of variance (ANOVA), and p < 0.05 was considered to be statistically significant.

성능/효과

The CV for the isoflurane/remifentanil group is much lower than that of the isoflurane/fentanyl group. It could be suggested that the CV for the isoflurane/fentanyl group was significantly high; therefore, the isoflurane/remifentanil group would exhibit a relatively stable effect. In particular, the isoflurane/ remifentanil group was remarkably more stable than the isoflurane/fentanyl group in terms of the sternal recumbency time, standing time, walking time, and complete recovery time.
This study showed that isoflurane/remifentanil combination anesthesia produced adequate anesthesia and is a better choice than isoflurane/fentanyl in severely ill patients because the recovery time in the isoflurane/remifentanil group was more constant and predictable compared to that in the isoflurane/ fentanyl group. Therefore, isoflurane/remifentanil combination anesthesia could be a better choice than isoflurane/ fentanyl anesthesia if the patient is severely ill and rapid recovery is needed.

참고문헌 (21)

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