[논문]Increased Risk of Childhood Acute Lymphoblastic Leukemia (ALL) by Prenatal and Postnatal Exposure to High Voltage Power Lines : A Case Control Study in Isfahan, Iran

Tabrizi, Maral Mazloomi; Bidgoli, Sepideh Arbabi

doi:10.7314/apjcp.2015.16.6.2347

Increased Risk of Childhood Acute Lymphoblastic Leukemia (ALL) by Prenatal and Postnatal Exposure to High Voltage Power Lines : A Case Control Study in Isfahan, Iran 원문보기

Asian Pacific journal of cancer prevention : APJCP, v.16 no.6, 2015년, pp.2347 - 2350

Tabrizi, Maral Mazloomi (Department of Toxicology & Pharmacology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University) , Bidgoli, Sepideh Arbabi (Department of Toxicology & Pharmacology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University)

Abstract ▼ AI-Helper

Childhood acute lymphoblastic leukemia (ALL) is one of the most common hematologic malignancies, accounting for one fourth of all childhood cancer cases. Exposure to environmental factors around the time of conception or pregnancy can increase the risk of ALL in the offspring.This study aimed to evaluted the role of prenatal and postnatal exposure to high voltage power lines on the incidence of childhood ALL.This cross-sectional case control study was carried out on 22 cases and 100 controls who were born and lived in low socioeconomic families in Isfahan and hospitalized for therapeutic purposes in different hospitals from 2013-2014.With regard to the underlying risk factors, familial history and parental factors were noted but in this age, socioeonomic and zonal matched case control study, prenatal and childhood exposure to high voltage power lines was considered as the most important environmental risk factors of ALL (p=0.006, OR=3.651, CI 95%, 1.692-7.878). As the population was of low socioeconomic background, use of mobiles, computers and microwave was negligible. Moreover prenatal and postnatal exposure to indoor electrically charged objects was not determined to be a significant environmental factor. Thus, pre and post natal exposure to high voltage power lines and living in pollutant regions as well as familial influence could be described as risk factors of ALL for the first time in a low socioeconomic status Iranian population.

주제어

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제안 방법

Demographical variables were obtained from specific questionnaire items: Delivery related factors including place of birth, paternal and maternal ages at delivery, BMI, education, job, socioeconomic states, physical activity, Personal history of any disorders, birth weight at delivery; familial history of leukemia, mother’s irregular menstruation, marriage related factors including marital status of parents, age at marriage.
878).For some childhood cancers, such as acute lymphoblastic leukemia (ALL), there is evidence of an embryonic cell of origin (Marshall et al., 2014) therefore we assessed the prenatalfactors in this study at the first part of assessments and found the dramatic carcinogenic effects of living near high voltage power lines in prenatal and postnatal periods.
Information on hormone use was obtained from specific questionnaire items. They covered questions on ever and current use of oral contraceptive pills (OCPs), the brand names, age at start and total duration of the use. Other methods of contraception were recorded including use of intrauterine device, tubectomy and use of progestins.

데이터처리

To assess associations between parametric variables Student t-test and to evaluate nonparametric data, the chi square test was used. Relative risks and odds ratios were calculated by the Cochran-Mantel-Haenszel statistics using SPSS 16 and the odds ratios were reported for this case control retrospective study. When the odds ratio in cases was>1, if the probability values was <0.
Values were expressed as percent per population or as the mean standard deviation. To assess associations between parametric variables Student t-test and to evaluate nonparametric data, the chi square test was used. Relative risks and odds ratios were calculated by the Cochran-Mantel-Haenszel statistics using SPSS 16 and the odds ratios were reported for this case control retrospective study.

성능/효과

, 2013)on the prevalence of Leukemia and its possible risk factors.Although the obtained findings in the last study showed clear differences in the incidence rates of Leukemia based on age, gender, residence, and type of malignancy, ALL was considered as the most prevalent type of leukemia. For this reasons we focused on the paternal, maternal background factors, prenatal and postnatal environmental exposures in Isfahan as a city with higher levels of air pollution (Rashidi et al.
Identification of Familial background factors : Out of 50 evaluated background factors, familial history of leukemia was considered as the the most imprtant risk factor of ALL in this young (<12 years) population (p<0.001, OR=8.143, 95%CI 4.986-13.3).
In conclusion, his work has defined the forces of environmental exposures especially continuous pre and post natal exposure to high voltage power lines and living in pollutant regions through the parents or children as well as the role of previously described risk factors of ALL for the first time in low socioeconomic Iranian population. We confirmed here a new risk factor for ALL and suggest the hypothesis on embryonic origin of many other cancers which should be assessed in next studies in larger case control studies.

후속연구

In conclusion, his work has defined the forces of environmental exposures especially continuous pre and post natal exposure to high voltage power lines and living in pollutant regions through the parents or children as well as the role of previously described risk factors of ALL for the first time in low socioeconomic Iranian population. We confirmed here a new risk factor for ALL and suggest the hypothesis on embryonic origin of many other cancers which should be assessed in next studies in larger case control studies.

참고문헌 (23)

Bailey HD, Armstrong BK, de Klerk NH, et al (2010). Exposure to diagnostic radiological procedures and the risk of childhood acute lymphoblastic leukemia. Cancer Epidemiol Biomarkers Prev, 19, 2897-909.

상세보기
Bailey HD, Fritschi L, Metayer C et al., (2014). Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium. Cancer Causes Control, 25, 1351-67.

상세보기
Bailey HD, Fritschi L, Infante-Rivard C, et al (2014). Parental occupational pesticide exposure and the risk of childhood leukemia in the offspring: findings from the childhood leukemia international consortium. Int J Cancer, 135, 2157-72.

상세보기
Bailey HD, Miller M, Greenop KR et al., (2014). Paternal intake of folate and vitamins B6 and B12 before conception and risk of childhood acute lymphoblastic leukemia. Cancer Causes Control, 25, 1615-25.

상세보기
D'Angelo C, Costantini E, Kamal MA et al., (2015). Experimental model for ELF-EMF exposure: Concern for human health. Saudi J Biol Sci, 22, 75-84.

상세보기
Deziel NC, Rull RP, Colt JS, et al (2014). Polycyclic aromatic hydrocarbons in residential dust and risk of childhood acute lymphoblastic leukemia. Environ Res, 133, 388-95.

상세보기
Hashemizadeh H, Boroumand H, Noori R, et al (2013). Socioeconomic status and other characteristics in childhood leukemia. Iran J Ped Hematol Oncol, 3, 182-6.

상세보기
Hauri D, Spycher B, Huss A, et al (2013). Domestic radon exposure and risk of childhood cancer: a prospective census-based cohort study. Environ Health Perspect, 12, 1239-44.
Janghorbani M, Piraei E (2013). Association between air pollution and preterm birth among neonates born in Isfahan, Iran. J Res Med Sci, 18, 875-81.
Lupo PJ, Dietz DJ, Kamdar KY, et al (2014). Gene-environment interactions and the risk of childhood acute lymphoblastic leukemia: exploring the role of maternal folate genes and folic Acid fortification. Pediatr Hematol Oncol, 31, 160-8.

상세보기
Marshall GM, Carter DR, Cheung BB, et al (2014). The prenatal origins of cancer. Nat Rev Cancer, 14, 277-89.

상세보기
Metayer C, Milne E, Dockerty JD, (2014). Maternal supplementation with folic acid and other vitamins and risk of leukemia in offspring: a childhood leukemia international consortium study. Epidemiology, 25, 811-22.

상세보기
Milne E, Greenop KR, Scott RJ et al., (2015). Folate pathway gene polymorphisms, maternal folic Acid use, and risk of childhood acute lymphoblastic leukemia. Cancer Epidemiol Biomarkers Prev, 24, 48-56.

상세보기
Mohajer R, Salehi MH, Mohammadi J, et al (2013). The status of lead and cadmium in soils of high prevalenct gastrointestinal cancer region of Isfahan. J Res Med Sci, 18, 210-4.
Njoku K, Basta N, Mann KD et al., (2013). Socioeconomic variation in survival from childhood leukaemia in northern England, 1968-2010. Br J Cancer, 108, 2239-45.
Rajabli N, Naeimi-Tabeie M, Jahangirrad A, et al (2013). Epidemiology of leukemia and multiple myeloma in Golestan, Iran. Asian Pac J Cancer Prev, 14, 2233-6.
Rashidi M, Ramesht MH, Zohary M, et al (2013). Relation of air pollution with epidemiology of respiratory diseases in isfahan, Iran from 2005 to 2009. J Res Med Sci, 18, 1074-9.
Reisi N AA (2009). The metabolic syndrome in survivors of childhood acute lymphoblastic leukemia in Isfahan, Iran. J Res Med Sci, 14, 111-6.
Reisi N, Azhir A, Hashemipour M, et al (2014). A diversity of cancer incidence and mortality in west asian populations. Ann Glob Health, 80, 346-357.

상세보기
Sohrabi MR, Tarjoman T, Abadi A, et al (2010). Living near overhead high voltage transmission power lines as a risk factor for childhood acute lymphoblastic leukemia: a case-control study. Asian Pac J Cancer Prev, 11, 423-7.
Shi R, Gao Y, Zhang Y et al., (2013). Relationship between parental exposure to chemicals and risk of childhood acute leukemia. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 31, 413-7.

상세보기
Tahmasby B, Marnani AB, Maleki M, et al (2013). Blood malignancies in Mazandaran province of Iran. Asian Pac J Cancer Prev, 14, 1053-6.

원문보기 상세보기
Zierhut H, Linet MS, Robison LL, et al (2012). Family history of cancer and non-malignant diseases and risk of childhood acute lymphoblastic leukemia: a children's oncology group study. Cancer Epidemiol, 36, 45-51.

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