5개월령 코리안 숏헤어 새끼 고양이(몸무게 1.7 kg)가 상부호흡기 증상, 얼굴과 발/발바닥의 궤양과 부종 및 파행을 주증으로 내원하였다. 실험실 검사상, 백혈구감소증, 림프구 감소증, 췌장염 및 칼리시바이러스 감염증이 확인되었다. 진단은 고독성 칼리시바이러스 감염증에 대한 특이 임상증상과 PCR을 통한 칼리시바이러스 동정 및 다른 상부호흡기 감염을 배제함으로써 내려졌다. 상부호흡기 증상완화와 이차 감염에 대한 처치 및 보조요법을 약 한 달간 실시하였고, 환자는 이러한 치료를 통해 임상증상이 크게 개선되었다. 본 증례는 고독성 고양이 칼리시바이러스에 대한 첫 번째 발병증례이다.
5개월령 코리안 숏헤어 새끼 고양이(몸무게 1.7 kg)가 상부호흡기 증상, 얼굴과 발/발바닥의 궤양과 부종 및 파행을 주증으로 내원하였다. 실험실 검사상, 백혈구감소증, 림프구 감소증, 췌장염 및 칼리시바이러스 감염증이 확인되었다. 진단은 고독성 칼리시바이러스 감염증에 대한 특이 임상증상과 PCR을 통한 칼리시바이러스 동정 및 다른 상부호흡기 감염을 배제함으로써 내려졌다. 상부호흡기 증상완화와 이차 감염에 대한 처치 및 보조요법을 약 한 달간 실시하였고, 환자는 이러한 치료를 통해 임상증상이 크게 개선되었다. 본 증례는 고독성 고양이 칼리시바이러스에 대한 첫 번째 발병증례이다.
A 5 month old Korean domestic short haired male kitten (weighing 1.7 kg) was presented with primary complaints of upper respiratory disease (URD) signs and skin ulceration and edema on face, feet and footpad with lameness. Diagnostic test revealed leukopenia, lymphopenia, pancreatitis and feline cal...
A 5 month old Korean domestic short haired male kitten (weighing 1.7 kg) was presented with primary complaints of upper respiratory disease (URD) signs and skin ulceration and edema on face, feet and footpad with lameness. Diagnostic test revealed leukopenia, lymphopenia, pancreatitis and feline calicivirus (FCV) infection. Diagnosis of virulent systemic FCV (VS-FCV) was made on clinical signs, isolation of calicivirus via PCR and exclusion of other causes of acute upper respiratory disease. Therapeutic strategies were directed to lessen URD signs and to treat secondary bacterial infection and antiviral infection. One month after this therapy, skin lesions on face and feet and URD signs were much improved, although the lameness persisted mildly. To author's best knowledge, this is the first case reporting VS-FCV infection in a kitten in Korea.
A 5 month old Korean domestic short haired male kitten (weighing 1.7 kg) was presented with primary complaints of upper respiratory disease (URD) signs and skin ulceration and edema on face, feet and footpad with lameness. Diagnostic test revealed leukopenia, lymphopenia, pancreatitis and feline calicivirus (FCV) infection. Diagnosis of virulent systemic FCV (VS-FCV) was made on clinical signs, isolation of calicivirus via PCR and exclusion of other causes of acute upper respiratory disease. Therapeutic strategies were directed to lessen URD signs and to treat secondary bacterial infection and antiviral infection. One month after this therapy, skin lesions on face and feet and URD signs were much improved, although the lameness persisted mildly. To author's best knowledge, this is the first case reporting VS-FCV infection in a kitten in Korea.
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가설 설정
Skin lesions after 1 month of therapy. A: Skin lesions (including edema) on face were much improved. B: Ulcerations on nose and lips were much improved.
Skin lesions on the first presentation. A: There was marked facial edema with alopecia, crusting, and ulceration of the nose, lips and pinnae. B: Marked ulceration was noticed on nose and lips.
A: There was marked facial edema with alopecia, crusting, and ulceration of the nose, lips and pinnae. B: Marked ulceration was noticed on nose and lips. C: There was mild limb edema with alopecia, crusting, and ulceration of feet and toes.
A: Skin lesions (including edema) on face were much improved. B: Ulcerations on nose and lips were much improved.
B: Marked ulceration was noticed on nose and lips. C: There was mild limb edema with alopecia, crusting, and ulceration of feet and toes. D: Marked ulceration was noticed on footpad.
C: There was mild limb edema with alopecia, crusting, and ulceration of feet and toes. D: Marked ulceration was noticed on footpad.
대상 데이터
A 5 month old Korean domestic short haired male kitten (weighing 1.7 kg) was presented with primary complaints of anorexia, fever, nasal/ocular discharge, alopecia/crusting/ulceration of the nose, lips, pinnae, and feet, marked subcutaneous edema, and lameness. The kitten was vaccinated twice before presentation and had medical history of upper respiratory disease (URD) partially responsive to doxycycline and famciclover at the age of 4 month.
성능/효과
Laboratory tests revealed leukopenia (4.4 × 109/L, reference interval [RI] 5.5-19.5 × 109/L), lymphopenia (0.5 × 109/L, RI 1.2-3.2 × 109/L), decreased hemoglobin (8.6 g/dL, RI 9-15 g/dL) and hematocrit (27%, RI 30-47%), increased serum amylase (1500 U/L RI 300-1100 U/L), and decreased blood urea nitrogen (9 mg/dL, RI 10-30 mg/dL).
Later we stopped administering famciclover, because the PCR test ruled out FHV infection. One month after this therapy, skin lesions (including edema) on face and feet and URD signs were dramatically improved (Fig 2A and B), although the lameness persisted mildly. The kitten was eating well without forced feeding.
참고문헌 (10)
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