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NTIS 바로가기디지털융복합연구 = Journal of digital convergence, v.14 no.11, 2016년, pp.607 - 618
이다영 (대전대학교 뷰티건강관리학과) , 승윤철 (중부대학교 한방건강관리학과) , 정규진 (충남대학교 약학과)
In order to clarify the Gosambaeksunpibokhap-bang(GBBB)'s therapeutic possibility on atopic dermatitis (AD), influences of GBBB on the changes of various immune-related factors and histological changes in NC/Nga mice were evaluated. Experimental results are as follows. Sign of recovery from AD was o...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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Th1세포와 Th2세포의 활성 불균형의 주요 원인은 무엇인가? | AD 유발 원인 중 하나로 면역학적 체계이상이 관련되어 있는데, 이는 Th1세포와 Th2세포의 활성 불균형에 기인한다[34]. 불균형의 주요 원인은 Th1세포의 활성보다 Th2 세포의 월등한 활성증가를 유도하는 사이토카인 때문인데, 정상의 경우에는 이러한 사이토카인들이 상호 억제적인 균형을 유지하여 효과적인 방어기전을 수행하 나, 비정상적으로 과도하게 분비되는 경우 사이토카인들의 불균형을 초래하고, 알레르기 또는 만성 염증과 같이 오히려 숙주의 손상을 초래할 수 있다. 특히 IL-4, IL-5, IL-13 등과 같은 사이토카인을 생산하여 Th2 활성은 증가되며 Th1의 활성은 감소되는 특성을 보인다[35]. | |
아토피피부염은 무엇인가? | 아토피피부염(Atopic Dermatitis, AD)은 濕疹(습진), IgE 피부염(IgE Dermatitis), 異位性皮炎(이위성피염), 胎熱(태열) 등 여러 명칭으로 불리며, 심한 소양감, 홍반, 부종, 삼출물과 부스럼이 특징으로 나타나는 만성 습진성 염증 피부질환이다[1]. 대체로 피부가 건조한 편이며 이는 가려움증을 유발한다. | |
앞으로 AD의 유병률이 높아질 것이라 예상하는 이유는? | AD는 유․소아기에 시작하여 성인기까지 재발과 악화를 반복하는 만성 습진성 피부질환으로 환자들은 서양 의학적 치료로 증상의 조절은 가능하나 완치가 힘들다는 점을 인식하고 있다 [3]. 산업화가 가속화됨에 따라 인체에 항원으로 작용할 수 있는 물질들이 더욱 늘어나고 있어 향후 AD 유병률은 더욱 높아질 것으로 예상되며 실제 지난 몇 년 동안 AD 유병율은 지속적인 증가 추세로 보고되고 있으며 [4,5], 국민건강보험공단의 2010년도 통계자료에서는 전체 인구의 1%가 AD를 앓고 있는 것으로 조사되었다[6]. 특히 영 ‧ 유아 시기에 AD에 대한 적절한 치료가 이루어 지지 않으면 3명 중 2명은 천식이나 알레르기 비염으로 이행한다는 보고가 있어 이에 대한 적절한 치료법이 요구되고 있다[7]. |
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