Vajpayee, Shailja
(Department of Pediatric Medicine, Sir Padampat Mother and Child Health Institute, Swai Man Singh Medical College)
,
Sharma, Shiv Dayal
(Department of Pediatric Medicine, Sir Padampat Mother and Child Health Institute, Swai Man Singh Medical College)
,
Gupta, Rajkumar
(Department of Pediatric Medicine, Sir Padampat Mother and Child Health Institute, Swai Man Singh Medical College)
,
Goyal, Alok
(Department of Pediatric Medicine, Sir Padampat Mother and Child Health Institute, Swai Man Singh Medical College)
,
Sharma, Aakash
(Department of Pediatric Medicine, Sir Padampat Mother and Child Health Institute, Swai Man Singh Medical College)
Purpose: To study whether breastfeeding and breastfeeding status during gluten introduction influences the age at diagnosis of celiac disease (CD). In addition to study, whether the timing of gluten introduction influences the age at diagnosis of CD. Methods: It was a hospital based observational st...
Purpose: To study whether breastfeeding and breastfeeding status during gluten introduction influences the age at diagnosis of celiac disease (CD). In addition to study, whether the timing of gluten introduction influences the age at diagnosis of CD. Methods: It was a hospital based observational study. Total 198 patients diagnosed with CD as per modified European Society of Pediatric Gastroenterology, Hepatology and Nutrition (2012) criteria, aged between 6 months to 6 years were included. Detail history taken with special emphasis on breastfeeding and age of gluten introduction. Standard statistical methods used to analyze the data. Results: $Mean{\pm}standard$ deviation age of onset and diagnosis of CD in breastfed cases was $2.81{\pm}1.42$ years and $3.68{\pm}1.55$ years respectively as compared to $1.84{\pm}1.36$ years and $2.70{\pm}1.65$ years respectively in not breastfed cases (p<0.05). Those who had continued breastfeeding during gluten introduction and of longer duration had significantly delayed onset of disease. The age at onset of CD was under one year in 40.42% of the cases, who had started gluten before 6 months of age compared to only 12.58% of those who had started gluten later (p<0.001). The proposed statistical model showed that two variables, i.e., breast feeding status during gluten introduction and age at gluten introduction positively influencing the age at diagnosis of CD. Conclusion: Delayed gluten introduction to infant's diet along with continuing breastfeeding, delays symptomatic CD. However, it is not clear from our study that these infant feeding practices provide permanent protection against the disease or merely delays the symptoms.
Purpose: To study whether breastfeeding and breastfeeding status during gluten introduction influences the age at diagnosis of celiac disease (CD). In addition to study, whether the timing of gluten introduction influences the age at diagnosis of CD. Methods: It was a hospital based observational study. Total 198 patients diagnosed with CD as per modified European Society of Pediatric Gastroenterology, Hepatology and Nutrition (2012) criteria, aged between 6 months to 6 years were included. Detail history taken with special emphasis on breastfeeding and age of gluten introduction. Standard statistical methods used to analyze the data. Results: $Mean{\pm}standard$ deviation age of onset and diagnosis of CD in breastfed cases was $2.81{\pm}1.42$ years and $3.68{\pm}1.55$ years respectively as compared to $1.84{\pm}1.36$ years and $2.70{\pm}1.65$ years respectively in not breastfed cases (p<0.05). Those who had continued breastfeeding during gluten introduction and of longer duration had significantly delayed onset of disease. The age at onset of CD was under one year in 40.42% of the cases, who had started gluten before 6 months of age compared to only 12.58% of those who had started gluten later (p<0.001). The proposed statistical model showed that two variables, i.e., breast feeding status during gluten introduction and age at gluten introduction positively influencing the age at diagnosis of CD. Conclusion: Delayed gluten introduction to infant's diet along with continuing breastfeeding, delays symptomatic CD. However, it is not clear from our study that these infant feeding practices provide permanent protection against the disease or merely delays the symptoms.
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제안 방법
An association of independent and dependent variables studied to identify possible auto-correlation, and multi-co-linearity. The models were proposed and tested for the risk stratification of CD. Mean age of diagnosis of CD compared with the help of unpaired t-test between the patient those were breastfed and not breast fed.
대상 데이터
Data collected with the help of pre-designed proforma. During the study period of 1 year, 230 patients enrolled but 198 cases included in the study as per inclusion and exclusion criteria.
성능/효과
1). The proposed model for risk stratification was tested and found statistically significant (ANOVA, F=18.842, p＜0.05). R square was 0.
The result of multiple linear regression showed that the breastfeeding status at the time of gluten introduction is positively influencing the age at diagnosis of CD i.e., continuing breast feeding during gluten introduction to an infant’s diet and extending it beyond delays the age at diagnosis of CD.
The result of multiple linear regression statistical analysis showed that only two independent variables, i.e., “Breastfeeding Status during the Gluten Introduction” and “Age at the Gluten Introduction” significantly positively influencing the age at diagnosis of CD (p=0.000) (Table 5 and Fig. 1).
후속연구
, delayed gluten introduction to an infant’s diet while the infant still being breastfed delayed the age at diagnosis of CD and the more prolonged breastfeeding was associated with a later onset of CD. Further studies are required to ascertain the role of infant feeding practices in expression of CD.
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