Lee, Jun Ho
(Department of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine)
,
Park, Youngsoo
(Department of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine)
,
Choi, Kyoung Wook
(Department of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine)
,
Chung, Kyu-Jin
(Department of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine)
,
Kim, Tae Gon
(Department of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine)
,
Kim, Yong-Ha
(Department of Plastic and Reconstructive Surgery, Yeungnam University College of Medicine)
Background The use of acellular dermal matrix (ADM) in implant-based immediate breast reconstruction has been increasing. The current ADMs available for breast reconstruction are offered as aseptic or sterile. No published studies have compared aseptic and sterile ADM in implant-based immediate brea...
Background The use of acellular dermal matrix (ADM) in implant-based immediate breast reconstruction has been increasing. The current ADMs available for breast reconstruction are offered as aseptic or sterile. No published studies have compared aseptic and sterile ADM in implant-based immediate breast reconstruction. The authors performed a retrospective study to evaluate the outcomes of aseptic versus sterile ADM in implant-based immediate breast reconstruction. Methods Implant-based immediate breast reconstructions with ADM conducted between April 2013 and January 2016 were included. The patients were divided into 2 groups: the aseptic ADM (AlloDerm) group and the sterile ADM (MegaDerm) group. Archived records were reviewed for demographic data and postoperative complication types and frequencies. The complications included were infection, flap necrosis, capsular contracture, seroma, hematoma, and explantation for any cause. Results Twenty patients were reconstructed with aseptic ADM, and 68 patients with sterile ADM. Rates of infection (15.0% vs. 10.3%), flap necrosis (5.0% vs. 7.4%), capsular contracture (20.0% vs. 14.7%), seroma (10.0% vs. 14.7%), hematoma (0% vs. 1.5%), and explantation (10.0% vs. 8.8%) were not significantly different in the 2 groups. Conclusions Sterile ADM did not provide better results regarding infectious complications than aseptic ADM in implant-based immediate breast reconstruction.
Background The use of acellular dermal matrix (ADM) in implant-based immediate breast reconstruction has been increasing. The current ADMs available for breast reconstruction are offered as aseptic or sterile. No published studies have compared aseptic and sterile ADM in implant-based immediate breast reconstruction. The authors performed a retrospective study to evaluate the outcomes of aseptic versus sterile ADM in implant-based immediate breast reconstruction. Methods Implant-based immediate breast reconstructions with ADM conducted between April 2013 and January 2016 were included. The patients were divided into 2 groups: the aseptic ADM (AlloDerm) group and the sterile ADM (MegaDerm) group. Archived records were reviewed for demographic data and postoperative complication types and frequencies. The complications included were infection, flap necrosis, capsular contracture, seroma, hematoma, and explantation for any cause. Results Twenty patients were reconstructed with aseptic ADM, and 68 patients with sterile ADM. Rates of infection (15.0% vs. 10.3%), flap necrosis (5.0% vs. 7.4%), capsular contracture (20.0% vs. 14.7%), seroma (10.0% vs. 14.7%), hematoma (0% vs. 1.5%), and explantation (10.0% vs. 8.8%) were not significantly different in the 2 groups. Conclusions Sterile ADM did not provide better results regarding infectious complications than aseptic ADM in implant-based immediate breast reconstruction.
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제안 방법
However, no published studies have compared aseptic and sterile ADM in implant-based immediate breast reconstruction. The authors performed a retrospective study to evaluate whether sterile ADM offers a potential advantage over aseptic ADM with respect to postoperative complications, and specifically, rates of infection in implant-based immediate breast reconstruction. The authors have no vested interest of any kind in the materials or services referred to in this article.
대상 데이터
Eighty-eight breast reconstructions from April 2013 to January 2016 were included in this study. All 88 patients underwent unilateral implant-based immediate breast reconstruction using a textured silicone gel implant (Allergan Corp.
General information on patient demographics, clinical course, and postoperative complications was collated. Patients were allocated to either the aseptic ADM group (AlloDerm) or the sterile ADM group (MegaDerm).
성능/효과
Our results showed no statistically significant differences between the 2 groups in terms of infection, flap necrosis, capsular contracture, seroma, hematoma, or overall explantation rates. It should be noted that sterile ADM showed complication rates equivalent to those observed using aseptic ADM, including rates of infectious complications.
후속연구
Although the sterilization of ADM did not demonstrate more preferable outcomes in terms of infection, sterile ADM has some advantages, including resistance to degradation by collagenase, improvement of durability, and strength due to crosslinking [18]. These biomechanical characteristics of sterile ADM need to be investigated in further studies.
참고문헌 (18)
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