[국내논문]택사(澤瀉)의 국내·외 연구동향과 『본초학』, 한국표준질병사인분류의 상관관계에 대한 연구 The Literature Study of Research Trend of Alismatis Rhizoma and Relationship Between the Herbology and KCD원문보기
Objectives : This study was aimed to analyze the correlation between the Herbology and contemporary research results, KCD and terms of Alismatis Rhizoma. The study will present information that can be used to find the direction of further researches and be applied to the education of Herbology.Metho...
Objectives : This study was aimed to analyze the correlation between the Herbology and contemporary research results, KCD and terms of Alismatis Rhizoma. The study will present information that can be used to find the direction of further researches and be applied to the education of Herbology.Methods : Papers were searched in Riss4U and PubMed, and categorized. Medicine or pharmacy articles about Alismatis Rhizoma were matched with the Herbology treatment and KCD. KCD-codes and terms were arranged by the Herbology treatment. The Degree of Herbology research (HDR) was calculated by numbers of papers, study method, citation rates.Results : There were 392 articles about Alismatis Rhizoma. Among these there were 141 medicine and pharmacy articles about Alismatis Rhizoma, and 51 articles were matched to the Herbology treatment. Studies about Phlegm-Fluid Retention and Dizziness, Edema and Distention and Fullness was more active than others. Analysis of other articles showed that studies about anti-cancer, anti-biotic effect, anti-diabetes mellitus, anti-oxidant effect, anti-inflammation, hepatoprotective effect were active, too. In HDR, Phlegm-Fluid Retention and Dizziness was scored by 181, Edema- Distention and Fullness by 173, Hyperlipidemia by 83, Dysuria 64, Heat strangury pain by 18, Diarrhea and decreased urine volum by 0.Conclusions : 141 articles about Alismatis Rhizoma were analyzed and 51 articles were matched to the Herbology treatment. Studies about Phlegm-Fluid Retention and Dizziness, Edema and Distention and Fullness were more active than others. And studies about anti-cancer, anti-biotic effect, anti-oxidant effect, anti-inflammation, Osteoporosis should be more studied and be more discussed among Herbology researchers.
Objectives : This study was aimed to analyze the correlation between the Herbology and contemporary research results, KCD and terms of Alismatis Rhizoma. The study will present information that can be used to find the direction of further researches and be applied to the education of Herbology.Methods : Papers were searched in Riss4U and PubMed, and categorized. Medicine or pharmacy articles about Alismatis Rhizoma were matched with the Herbology treatment and KCD. KCD-codes and terms were arranged by the Herbology treatment. The Degree of Herbology research (HDR) was calculated by numbers of papers, study method, citation rates.Results : There were 392 articles about Alismatis Rhizoma. Among these there were 141 medicine and pharmacy articles about Alismatis Rhizoma, and 51 articles were matched to the Herbology treatment. Studies about Phlegm-Fluid Retention and Dizziness, Edema and Distention and Fullness was more active than others. Analysis of other articles showed that studies about anti-cancer, anti-biotic effect, anti-diabetes mellitus, anti-oxidant effect, anti-inflammation, hepatoprotective effect were active, too. In HDR, Phlegm-Fluid Retention and Dizziness was scored by 181, Edema- Distention and Fullness by 173, Hyperlipidemia by 83, Dysuria 64, Heat strangury pain by 18, Diarrhea and decreased urine volum by 0.Conclusions : 141 articles about Alismatis Rhizoma were analyzed and 51 articles were matched to the Herbology treatment. Studies about Phlegm-Fluid Retention and Dizziness, Edema and Distention and Fullness were more active than others. And studies about anti-cancer, anti-biotic effect, anti-oxidant effect, anti-inflammation, Osteoporosis should be more studied and be more discussed among Herbology researchers.
본 연구에서는 국내·외의 논문을 최대한 다수를 검색하여 확보된 논문들의 효능과 관련 질환을 분석하여 현대 연구 성과들이 본초학 교육에 활용되고 있는 『본초학』과의 상관관계를 확인하였고, 이러한 결과와 임상적인 연관성을 확보하기 위하여 한국표준질병사인분류(Korean Standard Classification of Diseases, KCD)와의 관련성을 분석하였다. 이로서 택사에 대한 교육과 연구에 필요한 기초 자료로서 제시하고자 한다.
따라서 한의학 교육 현장에서도 과학적, 통계적인 방법을 이용한 자료를 제시하고, 임상과의 연관성에 대한 교육을 진행해야 한다. 그러한 취지에서 본 연구에서는 과거 연구결과의 정수로 볼 수 있는 『본초학』과 현대 연구 성과물로 제시된 논문들, 그리고 한국표준질병사인분류와의 관계를 고찰하여 임상과의 관계를 분석하는 연구를 제시하고자 하였다.
그러한 취지에서 인터넷 논문 검색 포털을 이용하여 논문을 검색하고『본초학』의 기존 연구성과인 본초학적 주치와 현대의학적 연구의 연구정도를 평가하여 임상과의 연계성을 정리하여 보고하는 바이다.
그래서 본 연구에서는 택사를 연구한 논문들을 KCD-code와 연계시키는 작업을 진행하여 임상 현장에서 직접적인 응용이 가능하고 한의과 대학 교육현장 내 임상 교육에 있어서 좀 더 피부에 와닿는 자료로서 제시하고자 하였다.
제안 방법
의·약학 분야 중에서 논문의 초록을 참고하여 택사가 주요 연구 주제인 논문들과 택사가 주요 연구주제가 아닌 논문들을 분류한 후, 실험·연구방법을 파악하여 문헌연구(Literature Study), 시험관내 실험(in vitro), 시험관 및 동물실험(in vitro & in vivo), 동물실험(in vivo), 임상연구(in human)로 분류하였다
효능 또는 관련 질환과 상병명 코드는 논문의 초록과 실험 방법에서 사용한 실험 모델을 분석한 다음 KCD와 질병명 검색 사이트(http://kcdcode.co.kr/browse/main)를 참고하여 각각의 KCD-code를 대응시켰다
실험 방법에 따라 분류된 택사를 주요 연구주제로 한 의·약학 논문들은 논문의 초록과 실험 방법을 분석하여 효능 또는 관련 질환, 상병명 코드, 본초학 주치, 인용지수를 기술하였다
초록을 분석하여 세포, 동물, 임상 등 생체 혹은 일부 조직들을 이용하여 의학적 치료제로서 개발 가능성에 대한 연구논문들은 의·약학 분야 논문으로 분류하였고, 식물 자체 혹은 특정 성분 추출에 대한 연구 그리고 택사와 관련이 없는 논문은 비의·약학 분야 논문으로 분류하였으나, 본초학적으로 관련이 있다고 판단되는 내용들은 분석의 범주에 포함시켰다.
이렇게 효능과 질환별로 정리된 내용의 임상적 적용에 대한 분석을 위해서, 현재 진행되고 있는 연구들과 임상과의 연계성을 한국표준질병사인분류(Korean Standard Classification of Diseases, KCD)와 대응시켜 분류하였다
대상 데이터
인용지수는 구글 학술 검색(http://scholar.google.co.kr/)에 기술되어 있는 정보를 사용하였다.
택사와 관련된 문헌자료를 확보하기 위하여 사용된 논문 검색 사이트는 MEDLINE 데이터베이스를 주로 접근할 수 있게 해 주는 자유 검색 엔진인 PubMed (http://www.ncbi.nlm.nih.gov/pubmed/)와 국내 학술연구정보서비스 Riss4U,( http://www.riss.kr)을 검색 포탈로 사용하였다. PubMed에서는 'Alismatis Rhizoma', 'Alisma plantago-aquarica', 'Alisma orientalis', 'Alisma orientale'을 검색하였고, Riss4U에서는 '택사', 'Alismatis Rhizoma', 'Alisma plantago-aquarica' 'Alisma orientalis', 'Alisma orientale'을 검색하였다.
kr)을 검색 포탈로 사용하였다. PubMed에서는 'Alismatis Rhizoma', 'Alisma plantago-aquarica', 'Alisma orientalis', 'Alisma orientale'을 검색하였고, Riss4U에서는 '택사', 'Alismatis Rhizoma', 'Alisma plantago-aquarica' 'Alisma orientalis', 'Alisma orientale'을 검색하였다. 이 중 중복되는 논문은 제외 시켰고, 타 분야의 논문으로서 택사의 본초학적 해석과 관련이 없는 것으로 판단되는 논문은 제외 시켰다.
이 중 중복되는 논문은 제외 시켰고, 타 분야의 논문으로서 택사의 본초학적 해석과 관련이 없는 것으로 판단되는 논문은 제외 시켰다. 그 결과 2015년 12월 28일 기준 PubMed에서는 241건의 논문을 수집하였고, Riss4U에서는 324건의 논문을 수집하였다. 그 결과 총 392건의 논문을 본 연구에 활용하였다.
그 결과 2015년 12월 28일 기준 PubMed에서는 241건의 논문을 수집하였고, Riss4U에서는 324건의 논문을 수집하였다. 그 결과 총 392건의 논문을 본 연구에 활용하였다.
그 중 중복되는 논문을 제외하고 총 392건의 논문을 본 연구에 활용, 분석하였다
이론/모형
본초학적 주치와 현재 연구의 진행 상황을 비교하기 위하여 본초학 주치 항목별로 직관적인 분석이 가능하도록 하기 위하여 김5)의 연구지수 방정식을 인용하여 지수화한 다음 도식화 하였다(Fig. 2).
성능/효과
그 결과 小便不利 64, 水腫脹滿 173, 痰飮眩暈 181, 高脂血證 83, 熱淋澁痛 18, 泄瀉尿少 0 으로 주치별 연구지수가 도출되었으며 이를 토대로, 痰飮眩暈과 水腫脹滿이 현대 의약학에서 가장 활발하게 연구된 택사의 본초학적 주치임을 알 수 있었다.
후속연구
하지만 기원식물이 다르고 기원식물의 분포 지역도 다르므로 앞으로 택사에 대해 연구를 할 때에는 기원식물에 대한 정확한 분석과 선택과 분류가 필요 할 것 이라고 사료된다.
하지만 대부분이 in vivo 연구 수준이며, 앞으로 더욱 다양한 주제의 임상연구와 체계적인 문헌고찰까지 진행하여 더 심도 있는 근거를 구축할 필요성이 있다
그러나 본초학 주치와의 관계가 상정되지 않은 골다공증 질환에 대한 연구는 향후 교육과 연구에 있어서 논의할 만한 가치가 있다고 판단된다.
다만 『본초학』 주치에 기록되지 않은 항암효과 연구 11건은 추가적인 연구성과가 더 발표된다면 향후 교육에 반영될 수도 있는 내용인 것으로 사료된다.
또한 의학 교육의 궁극적인 목표인 임상적 활용 측면에서는 기초연구와 임상과의 관련성에 대한 연구를 통해서 '실험과 임상'의 연계성에 대한 고찰이 필요하다
이들 연구는 노138)의 연구를 제외하고는 모두 택사가 소화기, 신장에 독성을 유발하거나 부작용이 생길 수 있다는 내용이며, 이 내용이 『본초학』에 택사의 금기증으로 기록된 바 '腎虛精滑 無濕熱者는 복용을 忌한다'1)는 내용과 어떠한 관련성이 있을지에 대해서는 추가적인 연구를 진행할 필요가 있을 것으로 사료된다.
이러한 특정성분 추출과 약리학적 분석의 연구가 앞으로 더 진행 되어야 할 것 이라고 사료된다.
본초학을 배우는 학생에게는 교과서에서 말하는 내용과 그동안의 연구내용, 방향이 어느 정도 상관관계를 갖고 있는지를 확인할 필요가 있고, 본초학을 연구하는 사람들 입장에서는 현재 본초학과 상관관계를 갖고 있지 않은 연구들이 향후 본초학에서 어떻게 연구해야 할지에 대한 단서를 잡기 위해 체계적인 문헌연구가 필요하다
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