[국내논문]Iron Oxide Nanoparticle-incorporated Alginate Capsules as Magnetic Field-assisted Potential Delivery Platforms for Agriculture Pesticides and Biocontrol Agents원문보기
Lee, Dohyeon
(Department of Rural and Biosystems Engineering, Chonnam National University)
,
Choi, Kyoung Soon
(Advanced Nano-Surface Research Group, Korea Basic Science Institute (KBSI))
,
Kim, Daun
(Department of Rural and Biosystems Engineering, Chonnam National University)
,
Park, Sunho
(Department of Rural and Biosystems Engineering, Chonnam National University)
,
Kim, Woochan
(Department of Rural and Biosystems Engineering, Chonnam National University)
,
Jang, Kyoung-Je
(Department of Biosystems & Biomaterials Science and Engineering, Seoul National University)
,
Lim, Ki-Taek
(Department of Biosystems Engineering, Kangwon National University)
,
Chung, Jong Hoon
(Department of Biosystems & Biomaterials Science and Engineering, Seoul National University)
,
Seonwoo, Hoon
(Department of Industrial Machinery Engineering, Sunchon National University)
,
Kim, Jangho
(Department of Rural and Biosystems Engineering, Chonnam National University)
Purpose: Biocompatible capsules have recently been highlighted as a novel platform for delivering various components, such as drug, food, and agriculture pesticides, to overcome the current limitations of living systems, such as those in agriculture, biology, the environment, and foods. However, few...
Purpose: Biocompatible capsules have recently been highlighted as a novel platform for delivering various components, such as drug, food, and agriculture pesticides, to overcome the current limitations of living systems, such as those in agriculture, biology, the environment, and foods. However, few active targeting systems using biocompatible capsules and physical forces simultaneously have been developed in the agricultural engineering field. Methods: Here, we developed an active targeting delivery platform that uses biocompatible alginate capsules and controls movements by magnetic forces for agricultural and biological engineering applications. We designed and fabricated large-scale biocompatible capsules, using custom-made nozzles ejecting alginate solutions for encapsulation. Results: To develop the active target delivery platforms, we incorporated iron oxide nanoparticles in the large-scale alginate capsules. The sizes of alginate capsules were controlled by regulating the working conditions, such as concentrations of alginate solutions and iron oxide nanoparticles. Conclusions: We confirmed that the iron oxide particle-incorporated large-scale alginate capsules moved actively in response to magnetic fields, which will be a good strategy for active targeted delivery platforms for agriculture and biological engineering applications, such as for the controlled delivery of agriculture pesticides and biocontrol agents.
Purpose: Biocompatible capsules have recently been highlighted as a novel platform for delivering various components, such as drug, food, and agriculture pesticides, to overcome the current limitations of living systems, such as those in agriculture, biology, the environment, and foods. However, few active targeting systems using biocompatible capsules and physical forces simultaneously have been developed in the agricultural engineering field. Methods: Here, we developed an active targeting delivery platform that uses biocompatible alginate capsules and controls movements by magnetic forces for agricultural and biological engineering applications. We designed and fabricated large-scale biocompatible capsules, using custom-made nozzles ejecting alginate solutions for encapsulation. Results: To develop the active target delivery platforms, we incorporated iron oxide nanoparticles in the large-scale alginate capsules. The sizes of alginate capsules were controlled by regulating the working conditions, such as concentrations of alginate solutions and iron oxide nanoparticles. Conclusions: We confirmed that the iron oxide particle-incorporated large-scale alginate capsules moved actively in response to magnetic fields, which will be a good strategy for active targeted delivery platforms for agriculture and biological engineering applications, such as for the controlled delivery of agriculture pesticides and biocontrol agents.
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문제 정의
In contrast, large-scale capsules are appropriate to big-sized systems such as environmental and agricultural fields. Our study is to reveal the potential of ION-ACs as a carrier for controlled delivery for pesticides or biocontrol agents. Thus large-scale capsules would be appropriate to the purpose of study.
Thus large-scale capsules would be appropriate to the purpose of study. The current work is a basic study to confirm the reactivity of the ION-ACs to the magnetic fields. For fulfilling the purpose, large scale capsules as a model platform can achieve the characterization and reactivity to magnetic fields easily.
제안 방법
In this study, we prepared large-scale ION-incorporated alginate capsules (ION-ACs) and investigated the reactivity of the capsules under magnetic fields (Fig. 1). The capsules were made by ionic cross-linking of alginate, and various concentrations of IONs were inserted into the capsules to optimize the ION concentration.
Consequently, the ION-ACs will accomplish their role as biological or pesticide agents. In this work as a preliminary study, the alginate capsules were used as potential platfroms for the application of pesticides and biological agents. Thus we mainly focused on the magnetic sensitivity of ION-ACs.
In this study, the large-scale ION-ACs were developed as a platform for a magnetic field-assisted active targeted delivery system. The capsule sizes were sensitively controlled by altering the concentrations of alginate and IONs.
An increase in both alginate and ION concentrations gradually increased capsule diameter. Although not evaluated in this study, capsule diameters can be adjusted to wider ranges by adjusting the diameters of the nozzles used and release rates.
대상 데이터
Sodium alginate (9005-38-3), calcium chloride anhydrous (10043-52-4), and Tween® 20 (9305-64-5) were purchased from DAEJUNG (Busan, Korea).
Iron (II, III) oxide (97%, MKBZ5546V) was purchased from Sigma-Aldrich (St. Louis, MO, USA). Sodium alginate (9005-38-3), calcium chloride anhydrous (10043-52-4), and Tween® 20 (9305-64-5) were purchased from DAEJUNG (Busan, Korea).
이론/모형
Shapiro-Wilk test was used to evaluate the normal distribution of ION-ACs (p <0.05).
Duncan’s least significant difference (LSD) method was used to compare the means of the various properties of ION-ACs.
Each of error bars mean standard deviation, and Duncan’s LSD method was used for statistical analysis (n = 30, p < 0.05).
3). Shapiro-Wilk test was conducted to evaluate the normal distribution of experimental groups. The results were expressed in each of distribution charts.
성능/효과
Capsule uniformity was greatly affected by the concentrations of iron oxide nanoparticle and alginate. As a result, we evaluated that the ION-ACs which has 1.5 wt% alginate concentration generally showed normal distribution. Among them, 0.
05 is far from normal distribution. The analysis showed that the uniformity of the capsule was greatly affected by the concentrations of iron oxide nanoparticles and alginate. Thus, the concentrations of iron oxide nanoparticles and alginate are very important considerations for controlling the sizes of large-scale capsules.
후속연구
The development of portable magnetic field inducer will be able to control selective and targeted pesticides. The researches related to active targeting delivery will be carried out as a new study. Furthermore, the effectiveness of alginate as a drug carrier material is well known.
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