최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기대한한방내과학회지 = The journal of internal Korean medicine, v.38 no.6, 2017년, pp.1035 - 1048
최유경 (가천대학교 한의과대학 내과학교실) , 황귀서 (가천대학교 한의과대학 예방의학교실)
Objectives: This study was performed to investigate the effects of Gardenia jasminoides extract (GJ) on osteoclast differentiation and bone resorption in vitro. Methods: To investigate the effect of GJ on osteoclast differentiation, the mouse leukemic myeloid cell line RAW 264.7 was stimulated by RA...
핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
골다공증이 일어나는 원인은? | 골다공증은 조골세포 기능이 약물들에 의해 저해되어 뼈의 생성이 억제되거나, 호르몬 분비의 변화로 파골세포 기능이 증가하여 골 손실이 증가할때 나타난다2 . 따라서, 골다공증을 억제하여 뼈를 튼튼히 하기 위해서는 파골전구세포들이 파골세포로 분화하는 과정을 차단하거나 파골세포 작용을 억제하는 방법을 우선적으로 고려할 수 있으며, 조골세포 기능 활성화를 통한 골형성을 촉진하는 것도 유익한 방법이다. | |
치자란? | 치자는 치자나무(Gardenia jasminoides) 및 동속 식물의 열매로서 凉血解毒, 淸熱利濕, 瀉火除煩의 효능이 있어서 한의학적으로 열병이나 불면, 황달, 소갈이나 결막염, 출혈이 수반된 다양한 증상을 완화하는데 사용되었다6 . 또한, 음식의 색깔을 좋게 하여식욕을 촉진하기 위한 식품 원료로 사용되고 있다. | |
요리의 관점으로 치자의 장점은? | 치자는 치자나무(Gardenia jasminoides) 및 동속 식물의 열매로서 凉血解毒, 淸熱利濕, 瀉火除煩의 효능이 있어서 한의학적으로 열병이나 불면, 황달, 소갈이나 결막염, 출혈이 수반된 다양한 증상을 완화하는데 사용되었다6 . 또한, 음식의 색깔을 좋게 하여식욕을 촉진하기 위한 식품 원료로 사용되고 있다. |
Kling JM, Clarke BL, Sandhu NP. Osteoporosis prevention, screening, and treatment: a review. J Womens Health 2014;23(7):563-72.
Sweet MG, Sweet JM, Jeremiah MP, Galazka SS. Diagnosis and treatment of osteoporosis. Am Fam Physician 2009;79(3):193-200.
Miyamoto T, Suda T. Differentiation and function of osteoclasts. Keio J Med 2003;52(1):1-7.
Kim JH, Kim N. Regulation of NFATc1 in Osteoclast Differentiation. J Bone Metab 2014; 21(4):233-41.
Jeong BS, Shin MG. Do-hae Hyang-yak(Saeng-yak) Dae-sajeon. Seoul: Young-lim-sa; 1990, p. 925-6.
Yu Y, Feng XL, Gao H, Xie ZL, Dai Y, Huang XJ, et al. Chemical constituents from the fruits of Gardenia jasminoides Ellis. Fitoterapia 2012; 83(3):563-7.
Oshima T, Sagara K, Yoshida T, Tong YY, Zhang GD, Chen YH. Determination of geniposide, gardenoside, geniposidic acid and genipin-1-beta -gentiobioside in Gardenia jasminoides by high-performance liquid chromatography. J Chromatogr 1988;455:410-4.
Sung YY, Lee AY, Kim HK. The Gardenia jasminoides extract and its constituent, geniposide, elicit anti-allergic effects on atopic dermatitis by inhibiting histamine in vitro and in vivo. J Ethnopharmacol 2014;156:33-40.
Chen YH, Lan T, Li J, Qiu CH, Wu T, Gou HJ, et al. Gardenia jasminoides attenuates hepatocellular injury and fibrosis in bile ductligated rats and human hepatic stellate cells. World J Gastroenterol 2012;18(48):7158-65.
Akihisa T, Watanabe K, Yamamoto A, Zhang J, Matsumoto M, Fukatsu M. Melanogenesis inhibitory activity of monoterpene glycosides from Gardeniae Fructus. Chem Biodivers 2012; 9(8):1490-9.
Zhang HY, Liu H, Yang M, Wei SF. Antithrombotic activities of aqueous extract from Gardenia jasminoides and its main constituent. Pharm Biol 2013;51(2):221-5.
Lee JH, Lee DU, Jeong CS. Gardenia jasminoides Ellis ethanol extract and its constituents reduce the risks of gastritis and reverse gastric lesions in rats. Food Chem Toxicol 2009;47(6):1127-31.
Wang L, Pi Z, Liu S, Liu Z, Song F. Targeted metabolome profiling by dual-probe microdialysis sampling and treatment using Gardenia jasminoides for rats with type 2 diabetes. Sci Rep 2017; 7(1):1010-5.
Zhang H, Lai Q, Li Y, Liu Y, Yang M. Learning and memory improvement and neuroprotection of Gardenia jasminoides (Fructus gardenia) extract on ischemic brain injury rats. J Ethnopharmacol 2017;196:225-35.
Im M, Kim A, Ma JY. Ethanol extract of baked Gardeniae Fructus exhibits in vitro and in vivo anti-metastatic and anti-angiogenic activities in malignant cancer cells: Role of suppression of the NF- ${\kappa}B$ and HIF- $1{\alpha}$ pathways. Int J Oncol 2016;49(6):2377-86.
Atkins GJ, Findlay DM. Osteocyte regulation of bone mineral: a little give and take. Osteoporos Int 2012;23(8):2067-79.
Drake MT, Clarke BL, Oursler MJ, Khosla S. Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned. Endocr Rev 2017;38(4):325-50.
Kim J, Lee H, Kang KS, Chun KH, Hwang GS. Cordyceps militaris mushroom and cordycepin inhibit RANKL-induced osteoclast differentiation. J Med Food 2015;18(4):446-52.
Fong D, Bisson M, Laberge G, McManus S, Grenier G, Faucheux N, et al. Bone morphogenetic protein-9 activates Smad and ERK pathways and supports human osteoclast function and survival in vitro. Cell Signal 2013;25(4):717-28.
Kim J, Lee HK, Chang TS, Kang KS, Hwang GS. Inhibitory effect of brazilin on osteoclast differentiation and its mechanism of action. Int Immunopharmacol 2015;29(2):628-34.
Lu SY, Li M, Lin YL. MITF regulates osteoclastogenesis by modulating NFATc1 activity. Exp Cell Res 2014;328(1):32-43.
Park SH, Kim JY, Cheon YH, Baek JM, Ahn SJ, Yoon KH, et al. Protocatechuic Acid Attenuates Osteoclastogenesis by Downregulating JNK/c-Fos/NFATc1 Signaling and Prevents Inflammatory Bone Loss in Mice. Phytother Res 2016;30(4):604-12.
Zeng XZ, He LG, Wang S, Wang K, Zhang YY, Tao L, et al. Aconine inhibits RANKL -induced osteoclast differentiation in RAW264.7 cells by suppressing NF- ${\kappa}B$ and NFATc1 activation and DC-STAMP expression. Acta Pharmacol Sin 2016;37(2):255-63.
Song J, Jing Z, Hu W, Yu J, Cui X. ${\alpha}$ -Linolenic Acid Inhibits Receptor Activator of NF- ${\kappa}B$ Ligand Induced (RANKL-Induced) Osteoclastogenesis and Prevents Inflammatory Bone Loss via Downregulation of Nuclear Factor-KappaB-Inducible Nitric Oxide Synthases (NF- ${\kappa}B$ -iNOS) Signaling Pathways. Med Sci Monit 2017;23:5056-69.
Korbecki J, Baranowska-Bosiacka I, Gutowska I, Chlubek D. Cyclooxygenase pathways. Acta Biochim Pol 2014;61(4):639-49.
Laveti D, Kumar M, Hemalatha R, Sistla R, Naidu VG, Talla V, et al. Anti-inflammatory treatments for chronic diseases: a review. Inflamm Allergy Drug Targets 2013;12(5):349-61.
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.