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NTIS 바로가기생명과학회지 = Journal of life science, v.27 no.8 = no.208, 2017년, pp.965 - 973
하영래 ((주)HK바이오텍, 부설 HK항노화연구소) , 김정옥 ((주)HK바이오텍, 부설 HK항노화연구소) , 김영숙 ((주)HK바이오텍, 부설 HK항노화연구소)
Conjugated linoleic acid (CLA) is a group of positional and geometric isomers of linoleic acid with conjugated double bonds at C9,C11 and C10,C12 positions. Of possible CLA isomers, a naturally occurring CLA isomer is c9,t11-CLA which is produced from linoleic acid by linoleate isomerase from variou...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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CLA가 남성성호르몬인 testosterone의 생합성에 미치는 영향은 무엇인가? | CLA가 testosterone 생합성에 미치는 영향은 먼저 adipo-cytes에서 perilipin과 hormone-sensitive lipase (HSL)를 함유한 지방구 보호 coat를 형성하고, 이들 두 protein에 hyperphosphorylation을 일으키게 하며, perilipin이 지방구로부터 방출하고 HSL은 cholesteryl ester를 free cholesterol로 전환시키는 역할을 한다[47]. Leydig 세포에서도 adipocyte에서와 동일한 기전으로 testosterone 생성을 촉진한다[47, 54]. 두 번째로 CLA는 steroidogenesis에 관련되는 효소, 17α-hydroxylase/17,20-lyase (CYP17A1)의 발현을 촉진하여 testosterone 을 합성을 증가시킨다. R2C에 CLA 처리는 testosterone 생합성이 증가함과 동시에 CYP17A1의 mRNA와 protein 함량이 증가하였다[3]. 운동을 시킨 mice에서도 CLA는 plasma의 testosterone과 CYP17A1의 mRNA와 protein이 증가하였다[3]. | |
CLA란 무엇인가? | CLA는 C18 지방산의 C9,C11와 C10,C12 공역이중결합 위치에 c,t; t,c; c,c; t.t 입체이성체를 포괄적으로 총칭한다. 자연에 존재하는 이성체는 c9,t11-CLA로 박테리아의 linoleate isomerase에 의해 합성되기 때문에 유제품이나 낙농제품에 함유된 CLA는 이 이성체가 90% 이상이다[13]. | |
유제품이나 낙농제품에 함유된 CLA에 c9, t11-CLA 이성체가 90% 이상인 이유는? | t 입체이성체를 포괄적으로 총칭한다. 자연에 존재하는 이성체는 c9,t11-CLA로 박테리아의 linoleate isomerase에 의해 합성되기 때문에 유제품이나 낙농제품에 함유된 CLA는 이 이성체가 90% 이상이다[13]. 그러나 알카리 이성화에 의해 합성되어 시판되는 CLA에는 약 90% 정도가 c9,t11- CLA와 t10,c12-CLA가 거의 동일한량 함유되어 있다[14]. |
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