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NTIS 바로가기Journal of Korean biological nursing science, v.19 no.3, 2017년, pp.141 - 150
최승혜 (서울대학교 간호대학.간호과학연구소) , 최스미 (서울대학교 간호대학.간호과학연구소) , 곽충실 (서울대학교 노화.고령사회연구소) , 이해영 (호서대학교 간호학과.기초과학연구소)
Purpose: The purpose of this study was to investigate the effects of the Korean Dietary Approaches to Stop Hypertension (DASH) education program on oxidative stress, antioxidant capacity, and serum homocysteine (Hcy) level in elderly Korean women. Methods: This was a quasi-experimental study employi...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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콜레스테롤 섭취가 낮은 것이 무조건 좋은 것만이 아닌 이유는 무엇인가? | 그러나, 콜레스테롤 섭취가 낮은 것이 무조건 좋은 것은 아닐 수 있다. 콜레스테롤이 동맥경화의 주요 원인으로 알려져 있으나, 신체 내에서 중요한 호르몬의 성분이자 세포막의 구성성분이 되기 때문이다[11]. 선행연구에 따르면 포화지방산을 다가 불포화 혹은 단일 불포화지방산으로 바꾸었을 때 심혈관계 질환 예방 효과가 있는 것으로 보고되었다[11]. | |
노화과정은 무엇과 밀접한 관련이 있는가? | 노화과정은 활성산소(reactive oxygen species, ROS)와 우리 체내 항산화 능력 간의 불균형으로 인한 산화스트레스(oxidative stress)와 밀접한 관련이 있는 것으로 알려져 있다[1]. 산화스트레스는 심혈관계 질환, 호흡기, 근골격계 질환 같은 노인성 질환과 수명에 영향을 미친다[1,2]. | |
산화스트레스는 질병에 관련해 어떤 영향을 미치는가? | 노화과정은 활성산소(reactive oxygen species, ROS)와 우리 체내 항산화 능력 간의 불균형으로 인한 산화스트레스(oxidative stress)와 밀접한 관련이 있는 것으로 알려져 있다[1]. 산화스트레스는 심혈관계 질환, 호흡기, 근골격계 질환 같은 노인성 질환과 수명에 영향을 미친다[1,2]. 산화스트레스는 다양한 요인에 의해 발생하는 것으로 보고되었으며[1,2], 그 중 호모시스테인은 산화과정을 통해 동맥혈관에 급격한 산화스트레스를 유발하여[3] 동맥경화증의 독립적인 위험인자로 알려져 있다[4]. |
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Cabello-Verrugio C, Ruiz-Ortega M, Mosqueira M, Simon F. Oxidative stress in disease and aging: mechanisms and therapies. Oxidative Medicine and Cellular Longevity. 2016;2016:1-2. http://dx.doi.org/10.1155/2016/8786564
Moselhy SS, Demerdash SH. Plasma homocysteine and oxidative stress in cardiovascular disease. Disease Markers. 2003;19(1):27-31.
Guilland JC, Favier A, Potier de Courcy G, Galan P, Hercberg S. Hyperhomocysteinemia: an independent risk factor or a simple marker of vascular disease? 2. Epidemiological data. Pathologie Biologie (Paris) 2003;51(2):111-121. https://doi.org/10.1016/S0369-8114(03)00105-6
Mazurek K, Zmijewski P, Kozdron E, Fojt A, Czajkowska A, Szczypiorski P, et al. Cardiovascular risk reduction in sedentary postmenopausal women during organized physical activity. Kardiologia Polska. 2017;75(5): 476-485. http://dx.doi.org/10.5603/KP.a2017.0035
Jenkins DJ, Boucher BA, Ashbury FD, Sloan M, Brown P, El-Sohemy A, et al. Effect of current dietary recommendations on weight loss and cardiovascular risk factors. Journal of American College Cardiology. 2017;69(9):1103-1112. http://dx.doi.org/10.1016/j.jacc.2016.10.089
Baker EA, Barnidge EK, Schootman M, Sawicki M, Motton-Kershaw FL. Adaptation of a modified DASH diet to a rural African American community setting. American Journal of Preventive Medicine. 2016;51(6):967-974. http://dx.doi.org/10.1016/j.amepre.2016.07.014
Troyer JL, Racine EF, Ngugi GW, McAuley WJ. The effect of home-delivered Dietary Approach to Stop Hypertension (DASH) meals on the diets of older adults with cardiovascular disease. The American Journal of Clinical Nutrition. 2010;91(5):1204-1212. http://dx.doi.org/10.3945/ajcn.2009.28780
Sacks FM, Lichtenstein AH, Wu JHY, Appel LJ, Creager MA, Kris-Etherton PM, et al. Dietary fats and cardiovascular disease: a presidential advisory from the American Heart Association. Circulation. 2017;136(3):e1-e23. http://dx.doi.org/10.1161/CIR. 0000000000000510
Al-Aubaidy HA, Jelinek HF. Oxidative DNA damage and obesity in type 2 diabetes mellitus. European Journal of Endocrinology. 2011;164(6):899-904. http://dx.doi.org/10.1530/EJE-11-0053
Clarkson PM. Antioxidants and physical performance. Critical Reviews in Food Science and Nutrition. 1995;35(1-2):131-141.
Ji LL, Leeuwenburgh C, Leichtweis S, Gore M, Fiebig R, Hollander J, et al. Oxidative stress and aging. Role of exercise and its influences on antioxidant systems. Annals of the New York Academy of Sciences. 1998;854(1):102-107.
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Craig CL, Marshall AL, Sjostrom M, Bauman AE, Booth ML, Ainsworth BE, et al. International physical activity questionnaire: 12-country reliability and validity. Medicine and Science in Sports and Exercise. 2003;35(8):1381-1395. http://dx.doi.org/10.1249/01.MSS.0000078924.61453.FB
Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Analytical Biochemistry. 1996;239(1):70-76. http://dx.doi.org/10.1006/abio.1996.0292
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Garcia-Alonso FJ, Jorge-Vidal V, Ros G, Periago MJ. Effect of consumption of tomato juice enriched with n-3 polyunsaturated fatty acids on the lipid profile, antioxidant biomarker status, and cardiovascular disease risk in healthy women. European Journal of Nutrition. 2012;51(4):415-424. http://dx.doi.org/10.1007/s00394-011-0225-0
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Alomari MA, Khabour OF, Gharaibeh MY, Qhatan RA. Effect of physical activity on levels of homocysteine, folate, and vitamin B12 in the elderly. The Physician and Sportsmedicine. 2016;44(1):68-73. http://dx.doi.org/10.1080/00913847.2016.1135037
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