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Production and Its Anti-hyperglycemic Effects of γ-Aminobutyric Acid from the Wild Yeast Strain Pichia silvicola UL6-1 and Sporobolomyces carnicolor 402-JB-1 원문보기

Mycobiology, v.45 no.3, 2017년, pp.199 - 203  

Han, Sang-Min (Department of Biomedicinal Science and Biotechnology, Paichai University) ,  Lee, Jong-Soo (Department of Biomedicinal Science and Biotechnology, Paichai University)

Abstract ▼ AI-Helper 아이콘AI-Helper

This study was done to produce ${\gamma}$-aminobutyric acid (GABA) from wild yeast as well as investigate its anti-hyperglycemic effects. Among ten GABA-producing yeast strains, Pichia silvicola UL6-1 and Sporobolomyces carnicolor 402-JB-1 produced high GABA concentration of $134.4{\...

주제어

#Anti-hyperglycemic effects   #Gamma-aminobutyric acid   #Pichia silvicola UL6-1   #Sporobolomyces carnicolor 402-JB-1   #Wild yeast  

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대상 데이터

  • Angiotensin 1-converting enzyme from rabbit lung acetone powder, tyrosinase, xanthine oxidase, and γ-aminobutyric acid transaminase (GABase) from Pseudomonas fluorescens were purchased from Sigma-Aldrich (St. Louis, MO, USA).
  • Sprague-Dawley (SD) male rats, weighing 180–200 g and 7 weeks old, were purchased from Orientbio Co., Seongnam, Korea.
  • Ten yeast strains that were screened as GABA-producing yeasts in a previous paper [28] were used in this study.

이론/모형

  • The physiological activities of the cell-free extracts containing GABA from the selected yeast strains were determined as follows. Antihypertensive angiotensin I-converting enzyme (ACE) inhibitory activity was assayed by the method of Cushman and Cheung [29] using ACE from rabbit lung. Antioxidant activity was assayed with DPPH as the substrate [30], and superoxide dismutase-like activity was assayed by the method of Lee et al.
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참고문헌 (37)

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