Biosafety and Biosecurity Programme: Its Implementation, Requirements and Continuous Development at the Nanyang Technological University in Singapore원문보기
Tun, Tin
(School of Biological Sciences, Nanyang Technological University)
,
Preiser, Peter Rainer
(School of Biological Sciences, Nanyang Technological University)
In Singapore, biosafety and biosecurity measures are controlled by the Biological Agents and Toxins Act (BATA) and other requirements by regulatory agencies. The law prohibits and otherwise regulates the possession, use, import, transhipment, transfer, and transportation of biological agents, inacti...
In Singapore, biosafety and biosecurity measures are controlled by the Biological Agents and Toxins Act (BATA) and other requirements by regulatory agencies. The law prohibits and otherwise regulates the possession, use, import, transhipment, transfer, and transportation of biological agents, inactivated biological agents, and toxins that are of public health concern. The law also defines the facility requirements for high risk biological agents and toxins. The containment facility (BSL 3) is a minimum requirement to handle biological agents that falls under Schedule 1 (Risk Group 3). The Nanyang Technological University School of Biological Sciences Biosafety Level 3 Facility (NTU-SBS BSL 3) was designed specifically for research involving potential hazardous biological materials. The facility requires yearly re-certification by an approved facility certifier to meet the local requirements and international biosafety standards for a containment facility in many instances. On the other hand, most NTU researchers conduct biological projects involving biological agents with low or moderate risk groups (Risk Groups 1 and 2 or biological agents described in schedule 3 and 4 of BATA) and GMOs, which need only a BSL 2 laboratory. BSL 2 laboratories are yet to be legally certified or registered in Singapore. Institutional Biosafety Committee (IBC) identifies the requirements; defines a minimum standard in the safe control of biological risks and registers all BSL 2 laboratories in the NTU. Therefore, under the guidance of the IBC, the University Biosafety and Biosecurity Programme includes the audit and certification program as a unique and an internal exercise to bring NTU biosafety to a higher level.
In Singapore, biosafety and biosecurity measures are controlled by the Biological Agents and Toxins Act (BATA) and other requirements by regulatory agencies. The law prohibits and otherwise regulates the possession, use, import, transhipment, transfer, and transportation of biological agents, inactivated biological agents, and toxins that are of public health concern. The law also defines the facility requirements for high risk biological agents and toxins. The containment facility (BSL 3) is a minimum requirement to handle biological agents that falls under Schedule 1 (Risk Group 3). The Nanyang Technological University School of Biological Sciences Biosafety Level 3 Facility (NTU-SBS BSL 3) was designed specifically for research involving potential hazardous biological materials. The facility requires yearly re-certification by an approved facility certifier to meet the local requirements and international biosafety standards for a containment facility in many instances. On the other hand, most NTU researchers conduct biological projects involving biological agents with low or moderate risk groups (Risk Groups 1 and 2 or biological agents described in schedule 3 and 4 of BATA) and GMOs, which need only a BSL 2 laboratory. BSL 2 laboratories are yet to be legally certified or registered in Singapore. Institutional Biosafety Committee (IBC) identifies the requirements; defines a minimum standard in the safe control of biological risks and registers all BSL 2 laboratories in the NTU. Therefore, under the guidance of the IBC, the University Biosafety and Biosecurity Programme includes the audit and certification program as a unique and an internal exercise to bring NTU biosafety to a higher level.
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문제 정의
It is noted that introduction of a standardized biosafety training course at national level under Workforce Development Agency (WDA) program by the Ministry of Manpower is in process. The strength of this program is to standardize or harmonize practices in this area and to promote mutual recognition of competency of laboratory users from various institutions - hospitals, universities, polytechnics, research centers and other industries. When the program is ready and publicized, employers have to send their staff to the agency-approved training provider or training institute.
This study describes laboratory biosecurity planning for microbiological laboratories. Background of this study introduces the terms biosafety and biosecurity and looks at how they are used and what they mean in different settings.
Sources of additional technical information are listed at the Nanyang Technological University in Singapore. This study provides an overview of biosecurity/ biosafety and the practices, equipment, and facilities for the safe and secure handling of dangerous pathogens in a laboratory setting.
제안 방법
The in-house training program was approved by the IBC to train potential users of the NTU-SBS BSL 3 laboratory [6]. Program procedures consist of lectures, practical demonstrations and simulations, video learning, discussions, reviews and evaluation of training, and documentation. Training contents address related legislation, regulations, guidelines and facility requirements; biosafety culture and concepts; standard procedures and laboratory practices; laboratory instruments and their maintenance; emergency responses; administrative requirements; and application procedures or protocols adopted at the facility.
All air exhausted from the laboratory is filtered through HEPA filters [5]. The adopted comprehensive approach to biosafety is based on a combination of administrative controls, safety practices and procedures, engineering controls, and personal protective equipment. As the facility was designed to accommodate multipurpose-users with regular staff training and turnover; thus, user training plays a critical role.
대상 데이터
First 6 member IBC was established specifically for the management of the NTU-SBS BSL 3 facility in 2004. The committee was led by the SBS Chair and all IBC members were from the school. The IBC is responsible to formulate and review biosafety policies and programs including training of staff, conducting risk assessment, reviewing and approving the research projects.
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