[논문]Hemorrhagic Moyamoya Disease : A Recent Update

Fujimura, Miki; Tominaga, Teiji

doi:10.3340/jkns.2018.0101

Hemorrhagic Moyamoya Disease : A Recent Update 원문보기 논문타임라인

Journal of Korean Neurosurgical Society = 대한신경외과학회지, v.62 no.2, 2019년, pp.136 - 143

Fujimura, Miki (Department of Neurosurgery, Kohnan Hospital) , Tominaga, Teiji (Department of Neurosurgery, Tohoku University)

Abstract ▼ AI-Helper

Moyamoya disease (MMD) is a progressive cerebrovascular disease with unknown etiology, characterized by bilateral steno-occlusive changes at the terminal portion of the internal carotid artery and an abnormal vascular network formation at the base of the brain. MMD has an intrinsic nature to convert the vascular supply for the brain from internal carotid (IC) system to the external carotid (EC) system, as indicated by Suzuki's angiographic staging. Insufficiency of this 'IC-EC conversion system' could result not only in cerebral ischemia, but also in intracranial hemorrhage from inadequate collateral anastomosis, both of which represent the clinical manifestation of MMD. Surgical revascularization prevents cerebral ischemic attack by improving cerebral blood flow, and recent evidence further suggests that extracranial-intracranial bypass could powerfully reduce the risk of re-bleeding in MMD patients with posterior hemorrhage, who were known to have extremely high re-bleeding risk. Although the exact mechanism underlying the hemorrhagic presentation in MMD is undetermined, most recent angiographic analysis revealed the characteristic angio-architecture related to high re-bleeding risk, such as the extension and dilatation of choroidal collaterals and posterior cerebral artery involvement. We sought to update the current management strategy for hemorrhagic MMD, including the outcome of surgical revascularization for hemorrhagic MMD in our institute. Further investigations will clarify the optimal surgical strategy to prevent hemorrhagic manifestation in patients with MMD.

주제어

AI 본문요약
AI-Helper

* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.

제안 방법

Representative case of a 45-year-old woman with repeated hemorrhage in the bilateral hemispheres had been conservatively followed up in our institute. In light of the posterior location of the hemorrhage on the left hemisphere (Fig. 1), she underwent left STA-MCA bypass with EDMS without complication. The stump of STA was anastomosed to the M4 segment of left MCA with the temporary occlusion time of 21 minutes (Fig.

대상 데이터

1) Adult (aged from 16 to 65 years old),2) timing of bilateral revascularization within 1 to 12 months after the onset, 3) independent activity of daily living (modified Rankin Scale of 0 to 2), and 4) absence of major brain damage. The 80 patients were enrolled and randomized to non-surgical and surgical group who underwent bilateral direct EC-IC bypass. The result showed that the annual risk of re-bleeding was 2.

성능/효과

As a result, hemorrhagic MMD patients showed a significantly higher proportion of choroidal anastomosis (<0.001) and thalamic anastomosis (p=0.043) compared to ischemic MMD patients1).
Then the development of each collateral anastomosis was compared between MMD patients with anterior hemorrhage and those with posterior hemorrhage. The results showed that choroidal anastomosis was developed in 35 of 75 hemorrhagic hemispheres of 75 patients (46.7%). The development of choroidal anastomosis, as characterized by dilatation and extension of anterior choroidal artery beyond the level of lateral ventricle, as well as the PCA involvement were significantly associated with posterior hemorrhage, suggesting that choroi-dal anastomosis might be considered a potential source of posterior hemorrhage at high risk of re-bleeding¹³⁾.

후속연구

4 months. These results indicated that direct revascularization surgery for hemorrhagic MMD patients satisfying JAM criteria is a safe and effective management, although further evaluation with long-term follow-up in necessary to validate this strategy. Representative case of a 45-year-old woman with repeated hemorrhage in the bilateral hemispheres had been conservatively followed up in our institute.

참고문헌 (40)
타임라인 바로가기

Fujimura, Miki, Funaki, Takeshi, Houkin, Kiyohiro, Takahashi, Jun C., Kuroda, Satoshi, Tomata, Yasutake, Tominaga, Teiji, Miyamoto, Susumu. Intrinsic development of choroidal and thalamic collaterals in hemorrhagic-onset moyamoya disease: case-control study of the Japan Adult Moyamoya Trial. Journal of neurosurgery, vol.130, no.5, 1453-1459.

상세보기 타임라인에서 보기
Fujimura, Miki, Inoue, Takashi, Shimizu, Hiroaki, Saito, Atsushi, Mugikura, Shunji, Tominaga, Teiji. Efficacy of Prophylactic Blood Pressure Lowering according to a Standardized Postoperative Management Protocol to Prevent Symptomatic Cerebral Hyperperfusion after Direct Revascularization Surgery for Moyamoya Disease. Cerebrovascular diseases, vol.33, no.5, 436-445.

상세보기 타임라인에서 보기
Fujimura, M., Kaneta, T., Mugikura, S., Shimizu, H., Tominaga, T.. Temporary neurologic deterioration due to cerebral hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in patients with adult-onset moyamoya disease. Surgical neurology, vol.67, no.3, 273-282.

상세보기 타임라인에서 보기
Fujimura, Miki, Kaneta, Tomohiro, Shimizu, Hiroaki, Tominaga, Teiji. Cerebral ischemia owing to compression of the brain by swollen temporal muscle used for encephalo-myo-synangiosis in moyamoya disease. Neurosurgical review, vol.32, no.2, 245-249.

상세보기 타임라인에서 보기
Fujimura, Miki, Mugikura, Shunji, Kaneta, Tomohiro, Shimizu, Hiroaki, Tominaga, Teiji. Incidence and risk factors for symptomatic cerebral hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in patients with moyamoya disease. Surgical neurology, vol.71, no.4, 442-447.

상세보기 타임라인에서 보기
Fujimura, Miki, Niizuma, Kuniyasu, Inoue, Takashi, Sato, Kenichi, Endo, Hidenori, Shimizu, Hiroaki, Tominaga, Teiji. Minocycline Prevents Focal Neurological Deterioration Due to Cerebral Hyperperfusion After Extracranial-Intracranial Bypass for Moyamoya Disease. Neurosurgery, vol.74, no.2, 163-170.

상세보기 타임라인에서 보기
Fujimura, Miki, Shimizu, Hiroaki, Inoue, Takashi, Mugikura, Shunji, Saito, Atsushi, Tominaga, Teiji. Significance of Focal Cerebral Hyperperfusion as a Cause of Transient Neurologic Deterioration After Extracranial-Intracranial Bypass for Moyamoya Disease: Comparative Study With Non-Moyamoya Patients Using N-Isopropyl-p-[123I]Iodoamphetamine Single-Photon Emission Computed Tomography. Neurosurgery, vol.68, no.4, 957-965.

상세보기 타임라인에서 보기
Fujimura, M., Shimizu, H., Mugikura, S., Tominaga, T.. Delayed intracerebral hemorrhage after superficial temporal artery-middle cerebral artery anastomosis in a patient with moyamoya disease: possible involvement of cerebral hyperperfusion and increased vascular permeability. Surgical neurology, vol.71, no.2, 223-227.

상세보기 타임라인에서 보기
Fujimura, Miki, Sonobe, Shinya, Nishijima, Yasuo, Niizuma, Kuniyasu, Sakata, Hiroyuki, Kure, Shigeo, Tominaga, Teiji. Genetics and Biomarkers of Moyamoya Disease: Significance of RNF213 as a Susceptibility Gene. Journal of stroke : JoS, vol.16, no.2, 65-72.

상세보기 타임라인에서 보기
Fujimura, Miki, Tominaga, Teiji. Current Status of Revascularization Surgery for Moyamoya Disease: Special Consideration for Its ‘Internal Carotid-External Carotid (IC-EC) Conversion’ as the Physiological Reorganization System. The Tohoku journal of experimental medicine, vol.236, no.1, 45-53.

상세보기 타임라인에서 보기
10.2176/nmc.52.327
Fujimura, Miki, Watanabe, Mika, Narisawa, Ayumi, Shimizu, Hiroaki, Tominaga, Teiji. Increased expression of serum matrix metalloproteinase-9 in patients with moyamoya disease. Surgical neurology, vol.72, no.5, 476-480.

상세보기 타임라인에서 보기
Funaki, Takeshi, Takahashi, Jun C., Houkin, Kiyohiro, Kuroda, Satoshi, Takeuchi, Shigekazu, Fujimura, Miki, Tomata, Yasutake, Miyamoto, Susumu. Angiographic features of hemorrhagic moyamoya disease with high recurrence risk: a supplementary analysis of the Japan Adult Moyamoya Trial. Journal of neurosurgery, vol.128, no.3, 777-784.

상세보기 타임라인에서 보기
Funaki, Takeshi, Takahashi, Jun C., Houkin, Kiyohiro, Kuroda, Satoshi, Takeuchi, Shigekazu, Fujimura, Miki, Tomata, Yasutake, Miyamoto, Susumu. High rebleeding risk associated with choroidal collateral vessels in hemorrhagic moyamoya disease: analysis of a nonsurgical cohort in the Japan Adult Moyamoya Trial. Journal of neurosurgery, vol.130, no.2, 525-530.

상세보기 타임라인에서 보기
Funaki, Takeshi, Takahashi, Jun C., Yoshida, Kazumichi, Takagi, Yasushi, Fushimi, Yasutaka, Kikuchi, Takayuki, Mineharu, Yohei, Okada, Tomohisa, Morimoto, Takaaki, Miyamoto, Susumu. Periventricular anastomosis in moyamoya disease: detecting fragile collateral vessels with MR angiography. Journal of neurosurgery, vol.124, no.6, 1766-1772.

상세보기 타임라인에서 보기
Hayashi, K., Horie, N., Izumo, T., Nagata, I.. A nationwide survey on unilateral moyamoya disease in Japan. Clinical neurology and neurosurgery, vol.124, 1-5.

상세보기 타임라인에서 보기
Hayashi, Toshiaki, Shirane, Reizo, Fujimura, Miki, Tominaga, Teiji. Postoperative neurological deterioration in pediatric moyamoya disease: watershed shift and hyperperfusion : Clinical article. Journal of neurosurgery. Pediatrics, vol.6, no.1, 73-81.

상세보기 타임라인에서 보기
Houkin, Kiyohiro, Ishikawa, Tatsuya, Yoshimoto, Tetsuyuki, Abe, Hiroshi. Direct and indirect revascularization for Moyamoya disease surgical techniques and peri-operative complications. Clinical neurology and neurosurgery, vol.99, no.suppl2, S140-S143.

상세보기 타임라인에서 보기
Hwang, J. W., Yang, H. M., Lee, H., Lee, H. K., Jeon, Y. T., Kim, J. E., Lim, Y. J., Park, H. P.. Predictive factors of symptomatic cerebral hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in adult patients with moyamoya disease. British journal of anaesthesia : BJA, vol.110, no.5, 773-779.

상세보기 타임라인에서 보기
Irikura, K., Miyasaka, Y., Kurata, A., Tanaka, R., Fujii, K., Yada, K., Ran, S.. A source of haemorrhage in adult patients with moyamoya disease: The significance of tributaries from the choroidal artery. Acta neurochirurgica, vol.138, no.11, 1282-1286.

상세보기 타임라인에서 보기
Kaku, Yasuyuki, Morioka, Motohiro, Ohmori, Yuki, Kawano, Takayuki, Kai, Yutaka, Fukuoka, Hirofumi, Hirai, Toshinori, Yamashita, Yasuyuki, Kuratsu, Jun-ichi. Outer-diameter narrowing of the internal carotid and middle cerebral arteries in moyamoya disease detected on 3D constructive interference in steady-state MR image: is arterial constrictive remodeling a major pathogenesis?. Acta neurochirurgica, vol.154, no.12, 2151-2157.

상세보기 타임라인에서 보기
Kamada, Fumiaki, Aoki, Yoko, Narisawa, Ayumi, Abe, Yu, Komatsuzaki, Shoko, Kikuchi, Atsuo, Kanno, Junko, Niihori, Tetsuya, Ono, Masao, Ishii, Naoto, Owada, Yuji, Fujimura, Miki, Mashimo, Yoichi, Suzuki, Yoichi, Hata, Akira, Tsuchiya, Shigeru, Tominaga, Teiji, Matsubara, Yoichi, Kure, Shigeo. A genome-wide association study identifies RNF213 as the first Moyamoya disease gene. Journal of human genetics, vol.56, no.1, 34-40.

상세보기 타임라인에서 보기
Kang, H. S., Kim, J. H., Phi, J. H., Kim, Y. Y., Kim, J. E., Wang, K. C., Cho, B. K., Kim, S. K.. Plasma matrix metalloproteinases, cytokines and angiogenic factors in moyamoya disease. Journal of neurology, neurosurgery, and psychiatry, vol.81, no.6, 673-678.

상세보기 타임라인에서 보기
Kim, Jeong Eun, Oh, Chang Wan, Kwon, O-Ki, Park, Sukh Que, Kim, Sang Eun, Kim, Yu Kyeong. Transient Hyperperfusion after Superficial Temporal Artery/Middle Cerebral Artery Bypass Surgery as a Possible Cause of Postoperative Transient Neurological Deterioration. Cerebrovascular diseases, vol.25, no.6, 580-586.

상세보기 타임라인에서 보기
Kuroda, Satoshi, Hashimoto, Nobuo, Yoshimoto, Takashi, Iwasaki, Yoshinobu. Radiological Findings, Clinical Course, and Outcome in Asymptomatic Moyamoya Disease : Results of Multicenter Survey in Japan. Stroke, vol.38, no.5, 1430-1435.

상세보기 타임라인에서 보기
Kuroda, Satoshi, Ishikawa, Tatsuya, Houkin, Kiyohiro, Nanba, Rina, Hokari, Masaaki, Iwasaki, Yoshinobu. Incidence and Clinical Features of Disease Progression in Adult Moyamoya Disease. Stroke, vol.36, no.10, 2148-2153.

상세보기 타임라인에서 보기
KURODA, Satoshi, KASHIWAZAKI, Daina, AKIOKA, Naoki, KOH, Masaki, HORI, Emiko, NISHIKATA, Manabu, UMEMURA, Kimiko, HORIE, Yukio, NOGUCHI, Kyo, KUWAYAMA, Naoya. Specific Shrinkage of Carotid Forks in Moyamoya Disease: A Novel Key Finding for Diagnosis. Neurologia medico-chirurgica, vol.55, no.10, 796-804.

상세보기 타임라인에서 보기
Miyamoto, Susumu, Yoshimoto, Takashi, Hashimoto, Nobuo, Okada, Yasushi, Tsuji, Ichiro, Tominaga, Teiji, Nakagawara, Jyoji, Takahashi, Jun C., Yamada, Keisuke, Tomata, Yasutake, Fukui, Tsuguya, Fukuuchi, Yasuo, Ohmoto, Takashi, Kuwabara, Yasuo, Nagata, Izumi, Ono, Junichi, Machida, Toshio, Sakakibara, Ryuji, Yamane, Kanji, Okita, Shinji, Iwama, Toru, Kaku, Yasuhiko, Saito, Nobuhito, Fukuyama, Hidenao, Houkin, Kiyohiro, Kuroda, Satoshi, Yabe, Ichiro, Moriwaka, Fumio, Ogawa, Akira, Ogasawara, Kuniaki, Yoshida, Kenji, Fujii, Kiyotaka, Yamada, Masaru, Sato, Kimitoshi, Akutsu, Tsugio, Yamagata, Sen, Takeuchi, Shigekazu, Hayashi, Kentaro, Horie, Nobutaka, Yamada, Kazuo, Osato, Toshiaki, Watanabe, Toshiichi, Honjo, Kaori, Sako, Kazuya, Nakase, Hiroyuki, Kawaguchi, Shoichiro, Nisimura, Fumihiko, Yamao, Junichi, Naritomi, Hiroaki, Inoue, Tooru, Abe, Hiroshi, Suzuki, Akifumi, Ishikawa, Tatsuya, Akiyama, Yoshinori, Suenaga, Toshihiko, Fujimura. Effects of Extracranial–Intracranial Bypass for Patients With Hemorrhagic Moyamoya Disease : Results of the Japan Adult Moyamoya Trial. Stroke, vol.45, no.5, 1415-1421.

상세보기 타임라인에서 보기
Morioka, Motohiro, Hamada, Jun-Ichiro, Kawano, Takayuki, Todaka, Tatemi, Yano, Shigetoshi, Kai, Yutaka, Ushio, Yukitaka. Angiographic Dilatation and Branch Extension of the Anterior Choroidal and Posterior Communicating Arteries Are Predictors of Hemorrhage in Adult Moyamoya Patients. Stroke, vol.34, no.1, 90-95.

상세보기 타임라인에서 보기
Health Labour Sciences Research Grant for Research on Measures for Intractable Diseases : Guidelines for diagnosis and treatment of moyamoya disease (spontaneous occlusion of the circle of Willis) 245 2012
Ryoo, Sookyung, Cha, Jihoon, Kim, Suk Jae, Choi, Jin Wook, Ki, Chang-Seok, Kim, Keon Ha, Jeon, Pyoung, Kim, Jong-Soo, Hong, Seung-Chyul, Bang, Oh Young. High-Resolution Magnetic Resonance Wall Imaging Findings of Moyamoya Disease. Stroke, vol.45, no.8, 2457-2460.

상세보기 타임라인에서 보기
Sakata, H., Fujimura, M., Mugikura, S., Sato, K., Tominaga, T.. Local Vasogenic Edema without Cerebral Hyperperfusion after Direct Revascularization Surgery for Moyamoya Disease. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, vol.24, no.7, e179-e184.

상세보기 타임라인에서 보기
Suzuki, J, Takaku, A. Cerebrovascular "moyamoya" disease. Disease showing abnormal net-like vessels in base of brain.. Archives of neurology, vol.20, no.3, 288-299.

상세보기 타임라인에서 보기
Takahashi, Jun C., Funaki, Takeshi, Houkin, Kiyohiro, Inoue, Tooru, Ogasawara, Kuniaki, Nakagawara, Jyoji, Kuroda, Satoshi, Yamada, Keisuke, Miyamoto, Susumu, Yoshimoto, Takashi, Hashimoto, Nobuo, Tsuji, Ichiro, Tomata, Yasutake, Fukui, Tsuguya, Okada, Yasushi, Matsumoto, Masayasu, Fukuuchi, Yasuo, Ohmoto, Takashi, Kuwabara, Yasuo, Nagata, Izumi, Ono, Junichi, Machida, Toshio, Sakakibara, Ryuji, Yamane, Kanji, Okita, Shinji, Kumano, Kiyoshi, Iwama, Toru, Kaku, Yasuhiko, Saito, Nobuhito, Fukuyama, Hidenao, Yabe, Ichiro, Moriwaka, Fumio, Ogawa, Akira, Yoshida, Kenji, Fujii, Kiyotaka, Yamada, Masaru, Sato, Kimitoshi, Akutsu, Tsugio, Yamagata, Sen, Takeuchi, Shigekazu, Nagata, Izumi, Hayashi, Kentaro, Horie, Nobutaka, Yamada, Kazuo, Katano, Hiroyuki, Masago, Atsuo, Osato, Toshiaki, Watanabe, Toshiichi, Honjo, Kaori, Sako, Kazuya, Nakase, Hiroyuki, Kawaguchi, Shoichiro, Nishimura, Fumihiko, Yamao, Junichi, Naritomi, Hiroaki, Okada, Yasu. Significance of the Hemorrhagic Site for Recurrent Bleeding : Prespecified Analysis in the Japan Adult Moyamoya Trial. Stroke, vol.47, no.1, 37-43.

상세보기 타임라인에서 보기
Tashiro, Ryosuke, Fujimura, Miki, Mugikura, Shunji, Niizuma, Kuniyasu, Endo, Hidenori, Endo, Toshiki, Tominaga, Teiji. Paradoxical Association of Symptomatic Local Vasogenic Edema with Global Cerebral Hypoperfusion after Direct Revascularization Surgery for Adult Moyamoya Disease. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, vol.27, no.8, e172-e176.

상세보기 타임라인에서 보기
TOMINAGA, Teiji, SUZUKI, Norihiro, MIYAMOTO, Susumu, KOIZUMI, Akio, KURODA, Satoshi, TAKAHASHI, Jun C., FUJIMURA, Miki, HOUKIN, Kiyohiro. Recommendations for the Management of Moyamoya Disease: A Statement from Research Committee on Spontaneous Occlusion of the Circle of Willis (Moyamoya Disease) [2nd Edition]. 腦卒中の外科 = Surgery for cerebral stroke, vol.46, no.1, 1-24.

상세보기 타임라인에서 보기
Tu, Xian-kun, Fujimura, Miki, Rashad, Sherif, Mugikura, Shunji, Sakata, Hiroyuki, Niizuma, Kuniyasu, Tominaga, Teiji. Uneven cerebral hemodynamic change as a cause of neurological deterioration in the acute stage after direct revascularization for moyamoya disease: cerebral hyperperfusion and remote ischemia caused by the ‘watershed shift’. Neurosurgical review, vol.40, no.3, 507-512.

상세보기
Uchino, Haruto, Kuroda, Satoshi, Hirata, Kenji, Shiga, Tohru, Houkin, Kiyohiro, Tamaki, Nagara. Predictors and Clinical Features of Postoperative Hyperperfusion after Surgical Revascularization for Moyamoya Disease : A Serial Single Photon Emission CT/Positron Emission Tomography Study. Stroke, vol.43, no.10, 2610-2616.

상세보기 타임라인에서 보기
Uchino, Haruto, Nakayama, Naoki, Kazumata, Ken, Kuroda, Satoshi, Houkin, Kiyohiro. Edaravone Reduces Hyperperfusion-Related Neurological Deficits in Adult Moyamoya Disease : Historical Control Study. Stroke, vol.47, no.7, 1930-1932.

상세보기 타임라인에서 보기
Yuan, M., Liu, Z.q., Wang, Z.q., Li, B., Xu, L.j., Xiao, X.l.. High-resolution MR imaging of the arterial wall in moyamoya disease. Neuroscience letters, vol.584, 77-82.

상세보기 타임라인에서 보기

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증