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NTIS 바로가기생명과학회지 = Journal of life science, v.29 no.2 = no.226, 2019년, pp.191 - 197
파리야르라메스 (원광대학교 약학대학 약품연구소) , 바스또라통킹 (원광대학교 약학대학 약품연구소) , 서정원 (원광대학교 약학대학 약품연구소)
Parkinson's disease (PD) is a progressive neurodegenerative disease that mainly affects motor system with clinical features such as bradykinesia, rigidity, tremor and abnormal posture. PD is characterized by the death of dopaminergic neurons in the substantia nigra pars compacta, which is associated...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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파킨슨병은 무엇을 특징으로 하는가? | 파킨슨병은 운동완서, 근육경직, 진전 및 비정상적인 자세 등을 임상적 특징으로 하는 주로 운동 신경계에 영향을 주는 진행성 신경 퇴행성 질환이다. 파킨슨병은 산화 스트레스와 세포 내 신호 전달 경로의 조절 장애에 의한 뇌 흑색치밀부에서의 도파민성 신경세포의 사멸을 특징으로 한다. Quercetin의 주요 대사산물인 Quercetin-3-O-glucuronide (Q3GA)는 신경 보호 효과가 있는 것으로 보고 되어 왔다. | |
파킨슨병이란? | 파킨슨병은 운동완서, 근육경직, 진전 및 비정상적인 자세 등을 임상적 특징으로 하는 주로 운동 신경계에 영향을 주는 진행성 신경 퇴행성 질환이다. 파킨슨병은 산화 스트레스와 세포 내 신호 전달 경로의 조절 장애에 의한 뇌 흑색치밀부에서의 도파민성 신경세포의 사멸을 특징으로 한다. | |
Parkinson’s disease의 병리학적 특징은 ? | 파킨슨병(Parkinson’s disease)은 운동완서(bradykinesia), 근육경직(rigidity), 진전(tremor) 및 비정상적인 자세(abnormal posture) 등을 임상적 특징으로 하는 신경퇴행성 질환이다[8]. 파킨슨병의 병리학적 특징은 뇌 흑색치밀부(substantianigra pars compacta)에서의 도파민성 신경세포의 진행성 퇴행에 의한 선조체(striatum) 내의 도파민 감소이다[10]. 비록 이러한 신경세포의 사멸에 관여하는 분자 메커니즘이 완전히 이해되지는 못했지만, 산화 스트레스와 신호전달체계의 조절 이상에 의한 도파민성 신경세포의 사멸은 파킨슨병을 유발하는 원인으로 보고되어 왔다[20]. |
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