[논문]Risk of Recrudescence of Lymphatic Filariasis after Post-MDA Surveillance in Brugia malayi Endemic Belitung District, Indonesia

Santoso, Santoso; Yahya, Yahya; Supranelfy, Yanelza; Suryaningtyas, Nungki Hapsari; Taviv, Yulian; Yenni, Aprioza; Arisanti, Maya; Mayasari, Rika; Mahdalena, Vivin; Nurmaliani, Rizki; Marini, Marini; Krishnamoorthy, K.; Pangaribuan, Helena Ullyartha

doi:10.3347/kjp.2020.58.6.627

[국내논문] Risk of Recrudescence of Lymphatic Filariasis after Post-MDA Surveillance in Brugia malayi Endemic Belitung District, Indonesia 원문보기

The Korean journal of parasitology, v.58 no.6, 2020년, pp.627 - 634

Santoso, Santoso (Baturaja Unit for Health Research and Development, National Institute of Health Research and Development (NIHRD), Ministry of Health of Indonesia) , Yahya, Yahya (Baturaja Unit for Health Research and Development, National Institute of Health Research and Development (NIHRD), Ministry of Health of Indonesia) , Supranelfy, Yanelza (Baturaja Unit for Health Research and Development, National Institute of Health Research and Development (NIHRD), Ministry of Health of Indonesia) , Suryaningtyas, Nungki Hapsari (Baturaja Unit for Health Research and Development, National Institute of Health Research and Development (NIHRD), Ministry of Health of Indonesia) , Taviv, Yulian (Baturaja Unit for Health Research and Development, National Institute of Health Research and Development (NIHRD), Ministry of Health of Indonesia) , Yenni, Aprioza (Baturaja Unit for Health Research and Development, National Institute of Health Research and Development (NIHRD), Ministry of Health of Indonesia) , Arisanti, Maya (Baturaja Unit for Health Research and Development, National Institute of Health Research and Development (NIHRD)) , Mayasari, Rika , Mahdalena, Vivin , Nurmaliani, Rizki , Marini, Marini , Krishnamoorthy, K. , Pangaribuan, Helena Ullyartha

Abstract ▼ AI-Helper

Belitung district in Bangka-Belitung Province, Indonesia with a population of 0.27 million is endemic for Brugia malayi and 5 rounds of mass drug administration (MDA) were completed by 2010. Based on the results of 3 transmission assessment surveys (TAS), the district is declared as achieving elimination of lymphatic filariasis (LF) in 2017. The findings of an independent survey conducted by the National Institute of Health Research and Development (NIHRD) in the same year showed microfilaria (Mf) prevalence of 1.3% in this district. In 2019, NIHRD conducted microfilaria survey in 2 villages in Belitung district. Screening of 311 and 360 individuals in Lasar and Suak Gual villages showed Mf prevalence of 5.1% and 2.2% with mean Mf density of 120 and 354 mf/ml in the respective villages. Mf prevalence was significantly higher among farmers and fishermen compared to others and the gender specific difference was not significant. The results of a questionnaire based interview showed that 62.4% of the respondents reported to have participated in MDA in Lasar while it was 57.7% in Suak Gual village. About 42% of the Mf positive cases did not participate in MDA. Environmental surveys identified many swampy areas supporting the breeding of Mansonia vector species. Persistence of infection is evident and in the event of successful TAS3 it is necessary to monitor the situation and plan for focal MDA. Appropriate surveillance strategies including xenomonitoring in post-MDA situations need to be developed to prevent resurgence of infection. Possible role of animal reservoirs is discussed.

Keyword

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가설 설정

(A) The cephalic space has a ratio of width to length of 1:2. (B) microfilaria appeared dark-stained. (C) compact column of the nuclei.

제안 방법

A pre-tested semi-structured questionnaire was used to collect information on community awareness and practice on MDA and MMDP. This survey was conducted by trained technical staff prior to blood testing.
The survey team visited randomly selected households and one consenting family member aged over 17 years were interviewed in the local language. The questions included on the cause of LF, clinical consequences of LF infection, awareness on MDA and, adverse event (AE) experience in any during MDA.
9% in 2 sentinel sites. This survey was conducted 2 years before stopping MDA. Suak Gual, one of our study sites was a spot check site during that survey and no Mf positive was reported (personal communication, District Health Office).

대상 데이터

islands, with a population ranging from 6, 300 to 172,000. The study was conducted in 2 randomly selected villages. Suak Gual village situated in a small island, Mendanau Island.
The population of Lasar is 3, 278 living in 944 houses [6]. The study was conducted from April-November 2019, 2 years after the third TAS and 10 years stopping MDA. Patients with filarial lymphedema were reported in both the villages.
This survey was conducted by trained technical staff prior to blood testing. The survey team visited randomly selected households and one consenting family member aged over 17 years were interviewed in the local language. The questions included on the cause of LF, clinical consequences of LF infection, awareness on MDA and, adverse event (AE) experience in any during MDA.
Mean age of participants was 33 years and 39 years in Suak Gual and Lasar respectively. Relatively more individuals in the age class 10-20 yeas participated in the survey. Over 25% of the participants belong to either students or housewives, followed by farmers and fishermen
and history of participation in MDA Awareness and participation in MDA programme. As many as 246 and 280 respondents participated in the sociological survey, from Lasar and Suak Gual respectively. The knowledge on the cause of LF causes was low (Table 3), as over 70% of the respondents were not able to answer.

데이터처리

, Chicago, Illinois, USA). The difference in prevalence was tested for significance using chi-square test. Analysis of risk factor such as gender, occupation and history of participation in MDA was done using bivariate analysis.
The difference in prevalence was tested for significance using chi-square test. Analysis of risk factor such as gender, occupation and history of participation in MDA was done using bivariate analysis.

성능/효과

Bhd, 47600 Subang Jaya, Selangor, Malaysia). Results of periodical TAS surveys showed antibody prevalence below the threshold of 2%. The final TAS (TAS3) results showed that the incidence of new infection was below the threshold which is considered as the evidence for total interruption of transmission and the programme has declared elimination of LF in this district.
Results of periodical TAS surveys showed antibody prevalence below the threshold of 2%. The final TAS (TAS3) results showed that the incidence of new infection was below the threshold which is considered as the evidence for total interruption of transmission and the programme has declared elimination of LF in this district. On the contrary, our study results showed Mf prevalence above the threshold.

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용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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