최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기Korean chemical engineering research = 화학공학, v.58 no.2, 2020년, pp.286 - 292
김동호 (충남대학교 응용화학공학과) , 정성근 (충남대학교 응용화학공학과) , 이창수 (충남대학교 응용화학공학과)
This study presents an angular-based measurement on three-dimensional paper-based analytical devices (3D-PADs) for quantitative detection of albumin without using an image analyzer. We demonstrate a simple quantitative and straightforward approach based on the angle of the discolored area as detecti...
* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.
핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
단백뇨란? | 0 mg/ml 이상의 농도의 경우 단백뇨로 진단한다. 단백뇨는 정상인의 경우 알부민을 사구체에서 여과하지 않도록 되어 있으나, 신장 질환 등의 이유로 소변에서 알부민이 배출되는 현상이다. 이러한 단백뇨는 전신부종, 신부전증, 당뇨성 망막증 등 여러 합병증을 진단할 수 있으며, 치료를 하지 않을 경우 투석 또는 장기 이식이 필요할 수 있어 조기 진단 및 관리가 매우 중요하다. | |
거리기반의 직선형 농도 측정용 종이 칩은 무엇을 해결하기 위해 제시되엇나? | 이 설정된 구간을 이용하여 분석 물질의 검출 대상이 일정 구간 내의 농도 범위에 있음을 지정하는 분석 방법이다 [24,25]. 따라서, 반정량분석법인 요검사용 시험지로는 질병의 진행 상황 정도를 정량적으로 확인할 수 없으며, 질병 관리의 측면에서도 환자의 상태를 정량적으로 확인할 수 없다는 단점이 존재한다. | |
단백뇨 진단기기에는 무엇이 있나? | 기존의 소변검사를 통한 단백뇨 진단기기는 요검사용 시험지(urine dipstick)와 거리기반의 직선형 농도 측정용 종이 칩이 있다. 요검사용 시험지의 경우 소혈청알부민(bovine serum albumin, BSA)에 반응하는 tetrabromophenol blue (TBPB)가 흡수 패드에 흡착되어 있어, 소변을 시험지에 적신 후에 흡수 패드의 색 변화를 통하여 질병 진단에 활용한다. |
Na, K., "New Oral Agent for Treatment of Anemia in Patient with Chronic Kidney Disease: Prolyl Hydroxylase Inhibitor," The Korean Journal of Medicine, 94(1), 11-16(2019).
Gervais, L., De Rooij, N. and Delamarche, E., "Microfluidic Chips for Point of Care Immunodiagnostics," Advanced Materials, 23(24), H151-H176(2011).
Chin, C. D., Linder, V. and Sia, S. K., "Lab-on-a-chip Devices for Global Health: Past Studies and Future Opportunities," Lab on a Chip, 7(1), 41-57(2007).
Peeling, R. W., Holmes, K. K., Mabey, D. and Ronald, A., "Rapid Tests for Sexually Transmitted Infections (STIs): the Way Forward," Sexually Transmitted Infections, 82(suppl 5), v1-v6(2006).
Christwardana, M., Chung, Y., Tannia, D. C. and Kwon, Y. "Effects of the Gold Nanoparticles Including Different Thiol Functional Groups on the Performances of Glucose-oxidase-based Glucose Sensing Devices," Korean Journal of Chemical Engineering, 35(12), 2421-2429(2018).
Park, S. J., Kim, S., Kim, S. H., Park, K. M. and Hwang, B. H. "His-tagged Protein Immobilization on Cationic Ferrite Magnetic Nanoparticles," Korean Journal of Chemical Engineering, 35(6), 1297-1302(2018).
Son, J., Hwang, J., Lee, D., Khan, M. S., Jo, Y., Lee, K., Park, C., Chavan, S., Seo, Y. and Choi, Y., "Strategies for the Optimization of Bead-immunoassays for the Effective Detection of Target Biomolecules," Korean Journal of Chemical Engineering, 35(3), 805-811(2018).
Lee, M., Kim, J.-H. and Koo, H.-J., "Dielectrophoresis for Control of Particle Transport: Theory, Electrode Designs and Applications," Korean Chemical Engineering Research, 57(2), 149-163 (2019).
Heo, N. S., Oh, S. Y., Ryu, M. Y., Baek, S. H., Park, T. J., Choi, C., Huh, Y. S. and Park, and J. P., "Affinity Peptide-guided Plasmonic Biosensor for Detection of Noroviral Protein and Human Norovirus," Biotechnology and Bioprocess Engineering, 24(2), 318-325(2019).
Zhou, M., Yang, M. and Zhou, F., "Paper Based Colorimetric Biosensing Platform Utilizing Cross-linked Siloxane as Probe," Biosensors and Bioelectronics, 55, 39-43(2014).
Mu, X., Zhang, L., Chang, S., Cui, W. and Zheng, Z., "Multiplex Microfluidic Paper-based Immunoassay for the Diagnosis of Hepatitis C Virus Infection," Analytical Chemistry, 86(11), 5338-5344(2014).
Hong, W., Jeong, S.-G., Shim, G., Kim, D. Y., Pack, S. P. and Lee, C.-S., "Improvement in the Reproducibility of a Paper-based Analytical Device (PAD) Using Stable Covalent Binding between Proteins and Cellulose Paper," Biotechnology and Bioprocess Engineering, 23(6), 686-692(2018).
Maharjan, A., Alkotaini, B. and Kim, B. S. "Fusion of Carbohydrate Binding Modules to Bifunctional Cellulase to Enhance Binding Affinity and Cellulolytic Activity," Biotechnology and Bioprocess Engineering, 23(1), 79-85(2018).
Shin, J.-W., Yoon, J., Shin, M., Choi, and J.-W., "Electrochemical Dopamine Biosensor Composed of Silver Encapsulated $MoS_2$ Hybrid Nanoparticle," Biotechnology and Bioprocess Engineering, 24(1), 135-144(2019).
Hinberg, I. H., Katz, L. and Waddell, L. "Sensitivity of in vitro Diagnostic Dipstick Tests to Urinary Protein," Clinical Biochemistry, 11(2), 62-64(1978).
Bae, E., Park, H.-J., Yoon, J., Kim, Y., Choi, K. and Yi, J., "Bacterial Uptake of Silver Nanoparticles in the Presence of Humic Acid and $AgNO_3$ ," Korean Journal of Chemical Engineering, 28(1), 267-271(2011).
Yu, J. H., Jeong, S.-G., Lee, C.-S., Hwang, J.-Y., Kang, K.-T., Kang, H. and Lee, S.-H., "Fabrication of a Paper-based Analytical Device for Multiple Colorimetric Analysis via Inkjet-printing and Paper-cutting," BioChip Journal, 9(2), 139-143(2015).
Kolthoff, I. M. and Elving, P. J., Treatise on Analytical Chemistry, Part 1 (Vol. 13). John Wiley & Sons(1993).
Duy, L. T., Trung, T. Q., Dang, V. Q., Hwang, B.-U., Siddiqui, S., Son, I.-Y., Yoon, S. K., Chung, D. J. and Lee, N.-E., "Flexible Transparent Reduced Graphene Oxide Sensor Coupled with Organic Dye Molecules for Rapid Dual-Mode Ammonia Gas Detection," Advanced Functional Materials, 26(24), 4329-4338(2016).
Gohain, B. and Dutta, R. K., "Premicellar and Micelle Formation Behavior of Dye Surfactant Ion Pairs in Aqueous Solutions: Deprotonation of Dye in Ion Pair Micelles," Journal of Colloid and Interface Science, 323(2), 395-402(2008).
Suzuki, Y., "Guidance for Selecting the Measurement Conditions in the Dyebinding Method for Determining Serum Protein: Theoretical Analysis Based on the Chemical Equilibrium of Protein Error," Analytical Sciences, 17(11), 1263-1268(2001).
Gyure, W. L., "Comparison of Several Methods for Semiquantitative Determination of Urinary Protein," Clinical Chemistry, 23(5), 876-879(1977).
Jeong, S.-G., Lee, S.-H., Choi, C.-H., Kim, J. and Lee, C.-S. "Toward Instrument-free Digital Measurements: a Three-dimensional Microfluidic Device Fabricated in a Single Sheet of Paper by Double-sided Printing and Lamination," Lab on a Chip, 15(4), 1188-1194(2015).
Washburn, E. W., "Note on a Method of Determining the Distribution of Pore Sizes in a Porous Material," Proceedings of the National Academy of Sciences of the United States of America, 7(4), 115(1921).
Carrilho, E., Martinez, A. W. and Whitesides, G. M., "Understanding Wax Printing: a Simple Micropatterning Process for Paperbased Microfluidics," Analytical Chemistry, 81(16), 7091-7095(2009).
Compton, S. J. and Jones, C. G., "Mechanism of Dye Response and Interference in the Bradford Protein Assay," Analytical Biochemistry, 151(2), 369-374(1985).
Cao, W., Jiao, Q., Fu, Y., Chen, L. and Liu, Q., "Mechanism of the Interaction Between Bromophenol Blue and Bovine Serum Albumin," Spectroscopy Letters - Spectrosc Lett, 36, 197-209(2003).
Kong, T., You, J. B., Zhang, B., Nguyen, B., Tarlan, F., Jarvi, K. and Sinton, D., "Accessory-free Quantitative Smartphone Imaging of Colorimetric Paper-based Assays," Lab on a Chip, 19(11), 1991-1999(2019).
Morbioli, G. G., Mazzu-Nascimento, T., Stockton, A. M. and Carrilho, E., "Technical Aspects and Challenges of Colorimetric Detection with Microfluidic Paper-based Analytical Devices ( ${\mu}PADs$ ) - A Review," Analytica Chimica Acta, 970, 1-22(2017).
Kim, S., Kim, D. and Kim, S., "A Rapid Real-time Quantification in Hybrid Paper-polymer Centrifugal Optical Devices," Biosensors and Bioelectronics, 126, 200-206(2019).
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.