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NTIS 바로가기생명과학회지 = Journal of life science, v.30 no.4, 2020년, pp.402 - 409
김종오 (부경대학교 해양생명과학연구소)
Nervous necrosis virus (NNV) contains a bi-segmented viral genome, RNA1 (3.4 kb, RdRp), and RNA2 (1.4 kb, capsid protein) in a small particle (25 nm). Despite its extremely compact size, NNV has caused serious damage by infecting approximately 120 fish species worldwide since it was first reported i...
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핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
신경괴사증바이러스 유전자의 특징은 무엇인가? | 신경괴사증바이러스(NNV)는 25 nm의 작은 입자 크기에 RNA1 (3.4 kb, RdRp), RNA2 (1.4 kb, capsid protein) 두 가닥의 RNA를 유전정보를 가진다. NNV는 1980년대 말 처음 보고된 이후 전 세계적으로 120여종의 어류에 감염을 일으키며 심각한 피해를 일으키고 있는 바이러스이다. | |
바이러스성 신경괴사증은 어떤 양식어종에서 발생하는가? | Viral encephalopathy and retinopathy (VER)이라고도 불리는 바이러스성 신경괴사증 viral nervous necrosis (VNN)은 1980년대 말 일본에서 처음 보고된 이후 전 세계적으로 심각한 피해를 일으키고 있는 질병이다[29]. 최근까지의 연구에 따르면 VNN은 barramundi (Lates calcarifer), 터봇(Scophthalmus maximus) 등 유럽의 주요 양식어종을 비롯하여 줄전갱이(Pseudocaranx dentex), 돌돔(Oplegnathus fasciatus), 붉바리(Epinephelus akaara), 자바리(Epinephelus moara), 넙치(Paralichthys olivaceus) 등 우리나라 및 아시아 주요 양식어종에서도 발생하고 있으며 약 120여종 이상의 해산어에서 보고되고 있다[8, 11, 29]. VNN은 특히 여름철 고수온기에 종묘생산단계의 자어부터 성어에 이르기까지 폐사를 유발하며, 감염어는 뇌 신경세포의 괴사로 인한 비정상적인 유영이 나타난다[14]. | |
NNV란 언제 보고되었으며, 어떤 피해를 주는 바이러스인가? | 4 kb, capsid protein) 두 가닥의 RNA를 유전정보를 가진다. NNV는 1980년대 말 처음 보고된 이후 전 세계적으로 120여종의 어류에 감염을 일으키며 심각한 피해를 일으키고 있는 바이러스이다. NNV 감염에 의한 피해를 최소화하고 효율적인 백신들을 개발하기 위해서는 무엇보다 NNV 감염에 따른 세포내 신호전달체계를 이해할 필요가 있다. |
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