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NTIS 바로가기한국산학기술학회논문지 = Journal of the Korea Academia-Industrial cooperation Society, v.21 no.8, 2020년, pp.417 - 428
채한화 (국립축산과학원 동물유전체과, 전남대학교 약학대학) , 노윤정 (국립축산과학원 동물유전체과) , 노희종 (국립축산과학원 가축유전자원센터) , 임다정 (국립축산과학원 동물유전체과)
Housekeeping genes are expressed in cells of all organisms and perform basic cellular functions such as energy generation, substance synthesis, cell death, and cell defense. Accordingly, the expression levels of housekeeping genes are relatively constant, and thus they are used as reference genes in...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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하우스키핑 유전자는 어떤 기능을 수행하는가? | 즉, 하우스키핑 유전자는 어떤 특정 조건에 상관없이 세포의 생명 활동 및 기능 유지에 필수적인 구성 유전자로, 여러 조건과 발달단계에서도 발현의 변화가 매우 적은 특징을 가지고 있다[1,2]. 하우스키핑 유전자는 세포내 DNA복제, 세포분열·증식·사멸과 같은 세포 수명 주기(life cycle) 유지, 에너지대사, 물질대사 등 다양한 기능을 하고 있다. 예를 들어, 세포외 자극 등 충격에 대비하는 열충격단백질, 세포내 단백질 발현에 관여하는 리보솜 단백질도 하우스키핑 유전자에 속한다. | |
유전자 발현 연구에서 하우스키핑 유전자가 중요한 이유는 무엇인가? | 하우스키핑 유전자는 에너지생성, 물질합성, 세포사멸 및 세포방어 등과 같은 세포의 기본적인 기능을 수행하기 때문에 모든 유기체의 세포에서 발현된다. 세포의 기본적인 기능을 유지하기 때문에 발현 수준이 상대적으로 일정하여 단백질 발현 및 목적 유전자의 mRNA 발현 분석 등과 같은 유전자 발현 연구에서 기준 유전자로 사용되고 있다. 그러나 이들 유전자의 발현 수준은 조직과 세포마다 다를 수 있으며, 특정 환경 하에서 변할 수 있다. | |
하우스키핑 유전자란 무엇인가? | 이와 반대로 생명체의 생존에 필수적인 유전자인 경우에는 어느 조직이나 세포에서 일정하게(consistent/stable) 발현이 되는데, 이 유전자를 하우스키핑 유전자(Housekeeping gene)라고 한다. 즉, 하우스키핑 유전자는 어떤 특정 조건에 상관없이 세포의 생명 활동 및 기능 유지에 필수적인 구성 유전자로, 여러 조건과 발달단계에서도 발현의 변화가 매우 적은 특징을 가지고 있다[1,2]. 하우스키핑 유전자는 세포내 DNA복제, 세포분열·증식·사멸과 같은 세포 수명 주기(life cycle) 유지, 에너지대사, 물질대사 등 다양한 기능을 하고 있다. |
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