[논문]Epitranscriptomic regulation of transcriptome plasticity in development and diseases of the brain

Park, Chan-Woo; Lee, Sung-Min; Yoon, Ki-Jun

doi:10.5483/bmbrep.2020.53.11.204

[국내논문] Epitranscriptomic regulation of transcriptome plasticity in development and diseases of the brain 원문보기

BMB reports, v.53 no.11, 2020년, pp.551 - 564

Park, Chan-Woo (Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)) , Lee, Sung-Min (Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)) , Yoon, Ki-Jun (Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST))

Abstract ▼ AI-Helper

Proper development of the nervous system is critical for its function, and deficits in neural development have been implicated in many brain disorders. A precise and predictable developmental schedule requires highly coordinated gene expression programs that orchestrate the dynamics of the developing brain. Especially, recent discoveries have been showing that various mRNA chemical modifications can affect RNA metabolism including decay, transport, splicing, and translation in cell type- and tissue-specific manner, leading to the emergence of the field of epitranscriptomics. Moreover, accumulating evidences showed that certain types of RNA modifications are predominantly found in the developing brain and their dysregulation disrupts not only the developmental processes, but also neuronal activities, suggesting that epitranscriptomic mechanisms play critical post-transcriptional regulatory roles in development of the brain and etiology of brain disorders. Here, we review recent advances in our understanding of molecular regulation on transcriptome plasticity by RNA modifications in neurodevelopment and how alterations in these RNA regulatory programs lead to human brain disorders.

Keyword

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문제 정의

Therefore, dysregulation of these post-translational regulatory programs often manifests as malformation or dysfunction of the normal CNS, which is implanted in various human brain disorders. In this review, we will overview the recent advances in our understanding of the transcriptome plasticity by RNA modifications in neurodevelopment, and how the alterations in these RNA regulatory programs lead to human brain disorders.

제안 방법

Similarly, epitranscriptomic factors have been suggested as applicable biomarkers and therapeutic targets in gastrointestinal cancer (134) and renal cancer (135). To identify biomarkers of glioblastoma, m⁶A-lncRNA co-expression networks were constructed through statistical analysis of primary glioblastoma patients, which screened four lncRNAs with their co-expressed functional genes. In that the lncRNA expression was correlated with the effect of m⁶A modification, it is suggested that posttranscriptional regulation of noncoding RNAs may have a significant role in dynamic gene expression control of glioblastoma (136).

후속연구

Unfortunately, there are no direct eraser and reader proteins identified so far, leaving the reversibility of pseudouridylation and the downstream mechanisms unclear. Taken together, further studies to screen regulatory proteins will be required for better understanding of this epitranscriptomic mark.

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표제어: PCR

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용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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