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문제 정의
- In a previous study, VLAS was measured in several breeds of healthy dogs (26). In our study, we focused on the VLAS values of three breeds with a predisposition to MMVD in South Korea. When we evaluated each breed, the median VLAS value of the Maltese was 2.
제안 방법
- CRP concentrations are elevated by over expression of myocardial cytokine in the atria and ventricles in dogs with heart failure induced by various cardiac diseases, including MMVD (21). Based on the VLAS cutoff value presented in a study published in 2020 (20), this study evaluated CRP by dividing the patients into groups according to the highest sensitivity value of 2.6 and the highest specificity value of 3.1.
- Furthermore, CRP increased proportionally as VLAS increased. In evaluating the size of the heart, it would be beneficial to measure VLAS in addition to the existing radiological and echocardiographic methods, thereby employing it as an additional diagnostic tool.
- Second, to compare the VLAS values of three breeds (Maltese, Shih-Tzu, and Poodle) with MMVD. Third, to confirm the correlation between CRP and VLAS in dogs with MMVD.
대상 데이터
- All dogs were examined at the Veterinary Medical Teaching Hospital of Chungnam National University between December 2017 and August 2020. Before initiating the experiment, the clients informed consent was obtained.
- Besides, 23 dogs were included to investigate CRP values in relation to VLAS. All the patients had cardiovascular symptoms at the time of their visit.
- The dogs in this study were classified by breed as follows: Maltese (n=67), Shih-Tzu (n=51), Poodle (n=37). Characteristic data such as age, weight, and sex for each breed, and radiographic and echocardiographic values according to breed were summarized (Table 2).
- Age, weight, and sex, with detailed data for each stage, were summarized (Table 1). The stage B1 group consisted of 88 dogs, and the Stage B2 and C-D groups comprised 46 dogs and 21 dogs, respectively.
- The study population comprised 155 dogs, classified by two criteria. The first was to classify the dogs according to their ACVIM stage.
- This study involved a total of 155 dogs with MMVD. All dogs were examined at the Veterinary Medical Teaching Hospital of Chungnam National University between December 2017 and August 2020.
데이터처리
- ">correction. Additionally, the Kruskal-Wallis test was conducted to evaluate the correlation between VLAS and CRP. A p value of <0.
이론/모형
- The values of each group, including age, weight, VHS, VLAS, LA/Ao ratio, and LVIDDN were reported as medians and interquartile ranges (IQR). The values among the three groups were compared using the Shapiro-Wilk test, and post hoc tests were conducted using the Bonferroni correction. Additionally, the Kruskal-Wallis test was conducted to evaluate the correlation between VLAS and CRP.
성능/효과
- All of the patients were classified as MMVD Stage B1, B2, or C-D according to the ACVIM guidelines (16). Also, the VHS, LA/Ao ratios, LVIDDN, and VLAS values of the species of Maltese (n=67), Shih-Tzu (n=51), and Poodle (n=37) were compared. Thirteen patients with postural errors and abnormal vertebrae and patients whose accurate readings were difficult due to distinct pulmonary edema were excluded.
- Due to the limitations of that study, it was suggested that further studies on various dog breeds affected by diseases are needed (26). In this study, there was no significant difference among the three breeds regarding VHS, LA/Ao ratios, LVIDDN, and VLAS. Mikawa et al.
- , USA). The values of each group, including age, weight, VHS, VLAS, LA/Ao ratio, and LVIDDN were reported as medians and interquartile ranges (IQR). The values among the three groups were compared using the Shapiro-Wilk test, and post hoc tests were conducted using the Bonferroni 1). When comparing the values such as VHS, LA/Ao ratio, LVIDDN, and VLAS between each group, there were significant differences between the B1 group and the B2 group (p<0.05), and the B1 group and the C-D group (p<0.05). When comparing the B2 group with the C-D group, only VLAS was observed to be significantly different (p<0.
- In our study, we focused on the VLAS values of three breeds with a predisposition to MMVD in South Korea. When we evaluated each breed, the median VLAS value of the Maltese was 2.40, the Shih-Tzu was 2.50, and the Poodle was 2.40. There was no significant difference among the breeds.
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