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호흡기 바이러스 감염의 진단법과 감염관리
Diagnostic Methods of Respiratory Virus Infections and Infection Control 원문보기

Korean journal of clinical laboratory science : KJCLS = 대한임상검사과학회지, v.53 no.1, 2021년, pp.11 - 18  

박창은 (남서울대학교 임상병리학과.분자진단연구소)

초록
AI-Helper 아이콘AI-Helper

호흡기 바이러스는 감염된 방문자와의 직접적인 접촉을 통해 병원 환경에서 감염된다. 감염관리 분야에서 호흡기 바이러스에 의한 병원내 획득 감염의 주요한 문제를 유발한다. 임상 검사실에서 파생된 감시 데이터는 또한 의료 서비스를 제공하는 기관과 공중 보건 분야에서 치료, 소모품 및 진단 제품 구매를 위해 병원과 지역 사회에 의료자원을 적절하게 배분하기 위해 종종 사용된다. 호흡기바이러스의 감염에서 조기 진단은 필수적이며 호흡기 검체를 사용하는 진단법에 활용될 수 있는 방법에는 바이러스 배양, 분자 진단 및 분석 등이 포함된다. 랩온어칩(LoC)/마이크로칩은 보다 다양하고 강력한 기술인 차세대 현장검사 시험법을 개발할 수 있는 새로운 전략으로 제공한다. 호흡기계의 중요성은 의료관련 종사자의 직업적 건강과 안전을 보장하기 위해 감염 관리 지침에 엄격히 적용되어야 한다. 이 연구를 포함하여 점점 더 많은 임상적 효능 증거가 감염 전파에 대한 오랜 패러다임에 도전하고 있다. 바이러스의 감염 가능성을 의심하는 새로운 호흡기 증상이 시작된 입원 환자로부터 호흡기 바이러스를 탐지하기 위한 빈번한 검사에 대해 추가 지원이 요구되고 감염통제의 노력에 집중적으로 도움이 이루어져야 할 것이다.

Abstract AI-Helper 아이콘AI-Helper

Respiratory viruses (RVs) cause infections in hospital environments through direct contact with infected visitors. In infection control, it causes major problems of acquired infections in hospitals by respiratory viruses. The surveillance data derived from clinical laboratories are often used to pro...

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표/그림 (4)

AI 본문요약
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문제 정의

  • These tests should increase our understanding of the epidemiology of respiratory virus infections. Finally, genotyping assays to detect antiviral resistance, which have also recently appeared, will provide clinicians with new information to improve patient management.
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참고문헌 (49)

  1. MacIntyre CR, Chughtai AA, Seale H, Richards GA, Davidson PMl. Respiratory protection for healthcare workers treating Ebola virus disease (EVD): are facemasks sufficient to meet occupational health and safety obligations? Int J Nurs Stud. 2014;51:1421-1426. https://doi.org/10.1016/j.ijnurstu.2014.09.002 

  2. Osterholm MT, Moore KA, Kelley NS, Brosseau LM, Wong G, Murphy FA, et al. Transmission of ebola viruses: what we know and what we do not know. MBio. 2015;6:e00137-15. https://doi.org/10.1128/mBio.00137-15 

  3. Otter JA, Yezli S, French GL. The role played by contaminated surfaces in the transmission of nosocomial pathogens. Infect Control Hosp Epidemiol. 2011;32:687-699. https://doi.org/10.1086/660363 

  4. Center for Disease Control and Prevention (CDC). Prevention Strategies for Seasonal Influenza in Healthcare Settings [Internet]. Atlanta: Center for Disease Control and Prevention; 2018 [cited 2020 November 16]. Available from: http://www.cdc.gov/flu/professionals/infectioncontrol/healthcaresettings.html 

  5. Song Q, Zhu R, Sun Y, Zhao L, Wang F, Deng J, et al. Identification of human metapneumovirus genotypes A and B from clinical specimens by reverse transcription loop-mediated isothermal amplification. J Virol Methods. 2014;196:133-138. https://doi.org/10.1016/j.jviromet.2013.10.037 

  6. Liu J, Nian QG, Li J, Hu Y, Li XF, Zhang Y, et al. Development of reverse-transcription loop-mediated isothermal amplification assay for rapid detection of novel avian influenza A (H7N9) virus. BMC Microbiol. 2014;14:271. https://doi.org/10.1186/s12866-014-0271-x 

  7. Shirato K, Yano T, Senba S, Akachi S, Kobayashi T, Nishinaka T, et al. Detection of Middle East respiratory syndrome coronavirus using reverse transcription loop-mediated isothermal amplification (RT-LAMP). Virol J. 2014;11:139. https://doi.org/10.1186/1743-422X-11-139 

  8. Yang S, Li H, Tang Y, Yu F, Ma C, Zhang H, et al. Multiplex tests for respiratory tract infections: the direct utility of the FilmArray respiratory panel in emergency department. Can Respir J. 2020;2020:6014563. https://doi.org/10.1155/2020/6014563 

  9. Center for Disease Control and Prevention. Interim infection prevention and control recommendations for hospitalized patients with Middle East respiratory syndrome CoronaVirus (MERS-CoV) [Internet]. Atlanta: Center for Disease Control and Prevention; 2014 [cited 2021 Jan 02]. Available from: http://www.cdc.gov/coronavirus/mers/infection-prevention-control.html. 

  10. MacIntyre CR, Chughtai AA, Seale H, Richards GA, Davidson PM. Uncertainty, risk analysis and change for Ebola personal protective equipment guidelines. Int J Nurs Stud. 2015;52:899-903. https://doi.org/10.1016/j.ijnurstu.2014.12.001 

  11. Chowell G, Fenimore PW, Castillo-Garsow MA, Castillo-Chavez C. SARS outbreaks in Ontario, Hong Kong and Singapore: the role of diagnosis and isolation as a control mechanism. J Theor Biol. 2003;224:1-8. https://doi.org/10.1016/s0022-5193(03)00228-5 

  12. Hall CB, Douglas RG, Jr, Geiman JM, Messner MK. Nosocomial respiratory syncytial virus infections. N Engl J Med. 1975;293:1343-1346. 

  13. Lessler J, Reich NG, Brookmeyer R, Perl TM, Nelson KE, Cummings DA, et al. Incubation periods of acute respiratory viral infections: a systematic review. Lancet Infect Dis. 2009;9:291-300. https://doi.org/10.1016/S1473-3099(09)70069-6 

  14. Haas LE, de Rijk NX, Thijsen SF. Human metapneumovirus infections on the ICU: a report of three cases. Ann Intensive Care. 2012;2:30. https://doi.org/10.1186/2110-5820-2-30 

  15. Ralston SL, Lieberthal AS, Meissner HC, Alverson BK, Baley JE, Gadomski AM, et al. Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis. Pediatrics. 2014;134:e1474-1502. https://doi.org/10.1542/peds.2014-2742 

  16. French CE, McKenzie BC, Coope C, Rajanaidu S, Paranthaman K, Pebody R, et al. Risk of nosocomial respiratory syncytial virus infection and effectiveness of control measures to prevent transmission events: a systematic review. Influenza Other Respir Viruses. 2016;10:268-290. https://doi.org/10.1111/irv.12379 

  17. Public Health Agency of Canada. Adenovirus [Internet]. Ottawa, Public Health Agency of Canada; 2011 [cited 2021 January 25]. Available from: http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/adenovirus-eng.php 

  18. Public Health Agency of Canada. Human coronavirus [Internet]. Ottawa, Public Health Agency of Canada; 2020 [cited 2021 January 25]. Available from: http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/coronavirus-eng.php 

  19. Public Health Agency of Canada. Human parainfluenza virus [Internet]. Ottawa, Public Health Agency of Canada; 2011 [cited 2021 January 25]. Available from: http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/parainfluenza-eng.php 

  20. Public Health Agency of Canada. Influenza virus type A [Internet]. Ottawa, Public Health Agency of Canada; 2011 [cited 2021 January 25]. Available from: http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/influenza-a-eng.php 

  21. Public Health Agency of Canada. Influenza virus type B [Internet]. Ottawa, Public Health Agency of Canada; 2012 [cited 2021 January 25]. Available from: http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/influenza-grippe-b-c-eng.php 

  22. Public Health Agency of Canada. Respiratory syncytial virus [Internet]. Ottawa, Public Health Agency of Canada; 2011 [cited 2021 January 25]. Available from: http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/pneumovirus-eng.php 

  23. Public Health Agency of Canada. Rhinovirus [Internet]. Ottawa, Public Health Agency of Canada; 2011 [cited 2021 January 25]. Available from: http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/rhinovirus-eng.php 

  24. Damasio GA, Pereira LA, Moreira SD, Duarte dos Santos CN, Dalla-Costa LM, Raboni SM. Does virus-bacteria coinfection increase the clinical severity of acute respiratory infection? J Med Virol. 2015;87:1456-1461. https://doi.org/10.1002/jmv.24210 

  25. Jiang W, Wang T, Li L, Ji W, Wang Y, Yan Y. Impact of bacteria in nasal aspirates on disease severity of bronchiolitis. Infect Dis (Lond). 2016;48:82-86. https://doi.org/10.3109/23744235.2015.1082621 

  26. Griffiths C, Drews SJ, Marchant DJ. Respiratory syncytial virus: Infection, detection, and new options for prevention and treatment. Clin Microbiol Rev. 2017;30:277-319. https://doi.org/10.1128/CMR.00010-16 

  27. Thorburn K, Harigopal S, Reddy V, Taylor N, van Saene HK. High incidence of pulmonary bacterial co-infection in children with severe respiratory syncytial virus (RSV) bronchiolitis. Thorax. 2006;61:611-615. https://doi.org/10.1136/thx.2005.048397 

  28. Ginocchio CC, Swierkosz E, McAdam AJ, Marcon M, Storch GA, Valsamakis A, et al. Multicenter study of clinical performance of the 3M rapid detection RSV test. J Clin Microbiol. 2010;48:2337-2343. https://doi.org/10.1128/JCM.00130-10 

  29. Schwartz RH, Selvarangan R, Zissman EN. BD Veritor system respiratory syncytial virus rapid antigen detection test: point-of-care results in primary care pediatric offices compared with reverse transcriptase polymerase chain reaction and viral culture methods. Pediatr Emerg Care. 2015;31:830-834. https://doi.org/10.1097/PEC.0000000000000371 

  30. Jonckheere S, Verfaillie C, Boel A, Van Vaerenbergh K, Vanlaere E, Vankeerberghen A, et al. Multicenter evaluation of BD Veritor System and RSV K-SeT for rapid detection of respiratory syncytial virus in a diagnostic laboratory setting. Diagn Microbiol Infect Dis. 2015;83:37-40. https://doi.org/10.1016/j.diagmicrobio.2015.05.012 

  31. Piche-Renaud PP, Turcot J, Chartrand C, Gravel J, Labrecque M, Vallieres E, et al. Evaluation of a fluorescent immunoassay rapid test (Sofia) for detection of influenza A+B and RSV in a tertiary pediatric setting. Diagn Microbiol Infect Dis. 2016;84:304-308. https://doi.org/10.1016/j.diagmicrobio.2015.10.025 

  32. Leonardi GP, Wilson AM, Dauz M, Zuretti AR. Evaluation of respiratory syncytial virus (RSV) direct antigen detection assays for use in point-of-care testing. J Virol Methods. 2015;213:131-134. https://doi.org/10.1016/j.jviromet.2014.11.016 

  33. Salez N, Nougairede A, Ninove L, Zandotti C, de Lamballerie X, Charrel RN. Prospective and retrospective evaluation of the Cepheid Xpert(R) Flu/RSV XC assay for rapid detection of influenza A, influenza B, and respiratory syncytial virus. Diagn Microbiol Infect Dis. 2015;81:256-258. https://doi.org/10.1016/j.diagmicrobio.2015.01.008 

  34. Popowitch EB, Miller MB. Performance characteristics of Xpert Flu/RSV XC assay. J Clin Microbiol. 2015;53:2720-2721. https://doi.org/10.1128/JCM.00972-15 

  35. Sun Y, Deng J, Qian Y, Zhu R, Wang F, Tian R, et al. Laboratory evaluation of rapid antigen detection tests for more-sensitive detection of respiratory syncytial virus antigen. Jpn J Infect Dis. 2019;72:394-398. https://doi.org/10.7883/yoken.JJID.2018.528 

  36. Cho CH, Lee CK, Nam MH, Yoon SY, Lim CS, Cho Y, et al. Evaluation of the AdvanSure real-time RT-PCR compared with culture and Seeplex RV15 for simultaneous detection of respiratory viruses. Diagn Microbiol Infect Dis. 2014;79:14-18. https://doi.org/10.1016/j.diagmicrobio.2014.01.016 

  37. Gharabaghi F, Hawan A, Drews SJ, Richardson SE. Evaluation of multiple commercial molecular and conventional diagnostic assays for the detection of respiratory viruses in children. Clin Microbiol Infect. 2011;17:1900-1906. https://doi.org/10.1111/j.1469-0691.2011.03529.x 

  38. Gadsby NJ, Hardie A, Claas EC, Templeton KE. Comparison of the Luminex respiratory virus panel fast assay with in-house real-time PCR for respiratory viral infection diagnosis. J Clin Microbiol. 2010;48:2213-2216. https://doi.org/10.1128/JCM.02446-09 

  39. Landry ML, Ferguson D. Comparison of Simplexa Flu A/B & RSV PCR with cytospin-immunofluorescence and laboratory-developed TaqMan PCR in predominantly adult hospitalized patients. J Clin Microbiol. 2014;52:3057-3059. https://doi.org/10.1128/JCM.00738-14 

  40. Centers for Disease Control and Prevention. Overview of Influenza Testing Methods [Internet]. Atlanta: Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases (NCIRD); 2020 [cited 2021 January 25]. Available from: https://www.cdc.gov/flu/professionals/diagnosis/overview-testing-methods.htm 

  41. Dawson ED, Moore CL, Dankbar DM, Mehlmann M, Townsend MB, Smagala JA, et al. Identification of A/H5N1 influenza viruses using a single gene diagnostic microarray. Anal Chem. 2007;79:378-384. 

  42. Syrmis MW, Whiley DM, Thomas, Mackay IM, Williamson J, Siebert DJ, et al. A sensitive specific and cost-effective multiplex reverse transcriptase-PCR assay for the detection of seven common respiratory viruses in respiratory samples. J Mol Diagn 2004;6:125-131. https://doi.org/10.1016/S1525-1578(10)60500-4 

  43. Mahony J, Chong S, Merante F, Luinstra K, Sinha T, Petrich A, et al. Development of a respiratory virus panel (RVP) test for the detection of twenty human respiratory viruses using multiplex PCR and a fluid microbead-based assay. J Clin Microbiol 2007;45:2965-2970. https://doi.org/10.1128/JCM.02436-06 

  44. Mesquita FDS, Oliveira DBL, Crema D, Pinez CMN, Colmanetti TC, Thomazelli LM, et al. Rapid antigen detection test for respiratory syncytial virus diagnosis as a diagnostic tool. J Pediatr (Rio J). 2017;93:246-252. https://doi.org/10.1016/j.jped.2016.06.013 

  45. Gralton J, Tovey E, McLaws ML, Rawlinson WD. The role of particle size in aerosolised pathogen transmission: a review. J Infect. 2011;62:1-13. https://doi.org/10.1016/j.jinf.2010.11.010 

  46. Musher D.M. How contagious are common respiratory tract infections? N Engl J Med. 2003;348:1256-1266. https://doi.org/10.1056/NEJMra021771 

  47. Somerville LK, Ratnamohan VM, Dwyer DE, Kok J. Molecular diagnosis of respiratory viruses. Pathology. 2015;47:243-249. https://doi.org/10.1097/PAT.0000000000000240 

  48. MacIntyre CR, Chughtai AA, Rahman B, Peng Y, Zhang Y, Seale H, et al. The efficacy of medical masks and respirators against respiratory infection in healthcare workers. Influenza Other Respir Viruses. 2017;11:511-517. https://doi.org/10.1111/irv.12474 

  49. Vemula SV, Zhao J, Liu J, Wang X, Biswas S, Hewlett I. Current approaches for diagnosis of influenza virus infections in humans. Viruses. 2016;8:96. https://doi.org/10.3390/v8040096 

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