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NTIS 바로가기BMB reports, v.54 no.6, 2021년, pp.305 - 310
Park, Seulki (Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)) , Kim, Kidae (Division of Biomedical Informatics, Center for Genome Science, National Institute of Health, KCDC) , Haam, Keeok (Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology) , Ban, Hyun Seung (Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology) , Kim, Jung-Ae (Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology) , Park, Byoung Chul (Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)) , Park, Sung Goo (Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)) , Kim, Sunhong (Drug Discovery Center, LG Chem) , Kim, Jeong-Hoon (Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB))
Cereblon (CRBN) is a multi-functional protein that acts as a substrate receptor of the E3 ligase complex and a molecular chaperone. While CRBN is proposed to function in mitochondria, its specific roles are yet to be established. Here, we showed that knockdown of CRBN triggers oxidative stress and c...
1 Friedman JR Nunnari J 2014 Mitochondrial form and function Nature 505 335 343 10.1038/nature12985 24429632
2 Hüttemann M Lee I Samavati L Yu H Doan JW 2007 Regulation of mitochondrial oxidative phosphorylation through cell signaling Biochim Biophys Acta 1773 1701 1720 10.1016/j.bbamcr.2007.10.001 18240421
4 Belhadj Slimen I Najar T Ghram A Dabbebi H Ben Mrad M Abdrabbah M 2014 Reactive oxygen species, heat stress and oxidative-induced mitochondrial damage. A review Int J Hyperthermia 30 513 523 10.3109/02656736.2014.971446 25354680
5 Shokolenko I Venediktova N Bochkareva A Wilson GL Alexeyev MF 2009 Oxidative stress induces degradation of mitochondrial DNA Nucleic Acids Res 37 2539 2548 10.1093/nar/gkp100 19264794
6 Ott M Gogvadze V Orrenius S Zhivotovsky B 2007 Mitochondria, oxidative stress and cell death Apoptosis 12 913 922 10.1007/s10495-007-0756-2 17453160
7 Ni H-M Williams JA Ding W-X 2015 Mitochondrial dynamics and mitochondrial quality control Redox Biol 4 6 13 10.1016/j.redox.2014.11.006 25479550
9 Bota DA Davies KJ 2016 Mitochondrial Lon protease in human disease and aging: including an etiologic classification of Lon-related diseases and disorders Free Radix Biol Med 100 188 198 10.1016/j.freeradbiomed.2016.06.031 27387767
10 Davalli P Mitic T Caporali A Lauriola A D'Arca D 2016 ROS, cell senescence, and novel molecular mechanisms in aging and age-related diseases Oxid Med Cell Longev 2016 3565127 10.1155/2016/3565127 27247702
11 Kataoka K Asahi T Sawamura N 2016 Mitochondrial cereblon functions as a Lon-type protease Sci Rep 6 29986 10.1038/srep29986 27417535
12 Kim MJ Min Y Shim J-H Chun E Lee K-Y 2019 CRBN is a negative regulator of bactericidal activity and autophagy activation through inhibiting the ubiquitination of ECSIT and BECN1 Front Immunol 10 3389 10.3389/fimmu.2019.02203 31620128
13 Zhou L Xu G 2019 Cereblon attenuates DNA damage-induced apoptosis by regulating the transcription-independent function of p53 Cell Death Dis 10 1 13 10.1038/s41419-019-1317-7 30683842
14 Kamogashira T Hayashi K Fujimoto C Iwasaki S Yama-soba T 2017 Functionally and morphologically damaged mitochondria observed in auditory cells under senescence-inducing stress NPJ Aging Mech Dis 3 1 11 10.1038/s41514-017-0002-2 28649419
15 Gunter T Buntinas L Sparagna G Eliseev R Gunter K 2000 Mitochondrial calcium transport: mechanisms and functions Cell calcium 28 285 296 10.1054/ceca.2000.0168 11115368
16 Görlach A Bertram K Hudecova S Krizanova O 2015 Calcium and ROS: a mutual interplay Redox Biol 6 260 271 10.1016/j.redox.2015.08.010 26296072
17 Fonteriz RI de la Fuente S Moreno A Lobatón CD Montero M Alvarez J 2010 Monitoring mitochondrial [Ca2+] dynamics with rhod-2, ratiometric pericam and aequorin Cell calcium 48 61 69 10.1016/j.ceca.2010.07.001 20667591
18 Lazarowski ER Boucher RC 2001 UTP as an extracellular signaling molecule Physiology 16 1 5 10.1152/physiologyonline.2001.16.1.1 11390937
19 Kim K Lee DH Park S 2019 Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera Sci Rep 9 1 14 10.1038/s41598-019-56177-5 30626917
20 Yamamoto H Itoh N Kawano S 2011 Dual role of the receptor Tom20 in specificity and efficiency of protein import into mitochondria Proc Natl Acad Sci U S A 108 91 96 10.1073/pnas.1014918108 21173275
21 Miyazono Y Hirashima S Ishihara N Kusukawa J Ohta K Nakamura K-i 2018 Uncoupled mitochondria quickly shorten along their long axis to form indented spheroids, instead of rings, in a fission-independent manner Sci Rep 8 1 14 10.1038/s41598-017-18582-6 29311619
22 Chen H Detmer SA Ewald AJ Griffin EE Fraser SE Chan DC 2003 Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development J Cell Biol 160 189 200 10.1083/jcb.200211046 12527753
23 Cao X Zhao S Liu D 2011 ROS-Ca2+ is associated with mitochondria permeability transition pore involved in surfactin-induced MCF-7 cells apoptosis Chem Biol Ineract 190 16 27 10.1016/j.cbi.2011.01.010 21241685
24 Baumgartner HK Gerasimenko JV Thorne C 2009 Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening J Biol Chem 284 20796 20803 10.1074/jbc.M109.025353 19515844
25 Pinti M Gibellini L Liu Y Xu S Lu B Cossarizza A 2015 Mitochondrial Lon protease at the crossroads of oxidative stress, ageing and cancer Cell Mol Life Sci 72 4807 4824 10.1007/s00018-015-2039-3 26363553
26 Lee KM Yang S-J Kim YD 2013 Disruption of the cereblon gene enhances hepatic AMPK activity and prevents high-fat diet-induced obesity and insulin resistance in mice Diabetes 62 1855 1864 10.2337/db12-1030 23349485
27 Lee KM Jo S Kim H Lee J Park C-S 2011 Functional modulation of AMP-activated protein kinase by cereblon Biochim Biophys Acta 1813 448 455 10.1016/j.bbamcr.2011.01.005 21232561
28 Hardie DG Ross FA Hawley SA 2012 AMPK: a nutrient and energy sensor that maintains energy homeostasis Nat Rev Mol Cell Biol 13 251 262 10.1038/nrm3311 22436748
29 Herzig S Shaw RJ 2018 AMPK: guardian of metabolism and mitochondrial homeostasis Nat Rev Mol Cell Biol 19 121 10.1038/nrm.2017.95 28974774
30 Mungai PT Waypa GB Jairaman A 2011 Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels Mol Cell Biol 31 3531 3545 10.1128/MCB.05124-11 21670147
31 Vives-Bauza C Zhou C Huang Y 2010 PINK1-dependent recruitment of Parkin to mitochondria in mitophagy Proc Natl Acad Sci U S A 107 378 383 10.1073/pnas.0911187107 19966284
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