[논문]Effect of Reducing Inflammation of Coptis chinensis Extract -Ceramide Complex through ECS Control in Atopic Dermatitis

Ahn, Sang Hyun; Kim, Ki Bong

doi:10.13048/jkm.21047

Effect of Reducing Inflammation of Coptis chinensis Extract -Ceramide Complex through ECS Control in Atopic Dermatitis 원문보기

Journal of Korean Medicine = 대한한의학회지, v.42 no.4, 2021년, pp.197 - 207

Ahn, Sang Hyun (Department of Anatomy, College of Korean Medicine, Semyung University) , Kim, Ki Bong (Department of Korean Pediatrics, Pusan National University Korean Hospital)

Abstract ▼ AI-Helper

Objectives: The purpose of this study was to confirm effect of reducing inflammation of Coptis chinensis extract-ceramide complex through the endocannabinoid system (ECS) control in atopic dermatitis. Methods: 8-week-old ICR mice were divided into normal group (Ctrl), lipid barrier elimination group (ADE), palmitoylethanolamide treated group after lipid barrier elimination (PEAT), and Coptis chinensis extract-ceramide complex applied group after lipid barrier elimination (CRA). After inducing atopic dermatitis, cannabinoid receptor (CB) 1, CB2, CD68, p-I𝜅B, iNOS, substance P and serotonin were observed to confirm the regulation of the ECS, macrophage activity and mast cell activity. Results: CB1 and CB2 showed higher positive reactions in the CRA than in the ADE and PEAT. CD68, p-I𝜅B and iNOS showed higher positive reaction in the ADE, PEAT and CRA than in the Ctrl, but the increase in the positive reaction was lower in the CEA compared to the ADE and PEAT. Substance P and serotonin showed higher positive reaction in the ADE, PEAT and CRA than in the Ctrl, but the increase in the positive reaction was lower in the CEA compared to the ADE and PEAT. Conclusions: The effects of Coptis chinensis extract -ceramide complex were confirmed on the regulation of the ECS, macrophage activity and mast cell activity.

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그림 Fig 1. The alleviation of ECS in skin barrier by application of Coptis chinensis extract-ceramide complex. CB1 and CB2 showed higher positive reactions in the CRA than in the ADE and PEAT. The expression of CB1 and CB2 (arrow indicates light brown particle) was significantly increased in the PEAT and CRA as compared with the ADE, the data of image analysis showed the same results. *, p < 0.05 compared with ADE; #, p < 0.05 compared with PEAT. Ctrl, normal group; ADE, lipid barrier elimination group; PEAT, palmitoylethanolamide (PEA) treated group after lipid barrier elimination; CRA, Coptis chinensis extract-ceramide complex applied group after lipid barrier elimination; EP, epithelium; DE, dermis; bar size, 50㎛.
그림 Fig 2. The regulation of macrophage activity in skin by application of Coptis chinensis extract-ceramide complex.CD68, p-IκB and iNOS (arrow indicates light brown particle) showed relatively higher positive reaction in the ADE, PEAT and CRA than in theCtrl, but the increase in the positive reaction was lower in the CEA compared to the ADE and PEAT. *, p < 0.05 compared with ADE; #, p< 0.05 compared with PEAT. abbrevation same as Fig. 1.
그림 Fig. 3. The regulation of mast cell in skin by application of Coptis chinensis extract-ceramide complex.The positive reaction of Substance P and serotonin (arrow indicates light brown particle) is higher in the ADE, PEAT and CRA than in the Ctrl,but the increase in the positive reaction was lower in the CEA compared to the ADE and PEAT. *, p < 0.05 compared with ADE; #, p < 0.05compared with PEAT. abbrevation same as Fig. 1.

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Effect of Reducing Inflammation of Coptis chinensis Extract -Ceramide Complex through ECS Control in Atopic Dermatitis 원문보기

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