[논문]박테리아 부착억제 고분자 기반 고체 표면의 항균 코팅 연구 동향

고상원; 이재영; 박덕신

doi:10.14478/ace.2021.1048

박테리아 부착억제 고분자 기반 고체 표면의 항균 코팅 연구 동향
Recent Progress of Antibacterial Coatings on Solid Substrates Through Antifouling Polymers 원문보기

공업화학 = Applied chemistry for engineering, v.32 no.4, 2021년, pp.371 - 378

고상원 (한국철도기술연구원 교통환경연구실) , 이재영 (한국철도기술연구원 교통환경연구실) , 박덕신 (한국철도기술연구원 교통환경연구실)

초록
AI-Helper

고체 표면의 박테리아 부착억제를 목적으로 고분자를 이용한 친수성 표면 개질 연구가 주목을 받고 있다. 부착억제기능은 세포독성이 아닌 작용으로 바이오필름 형성의 초기단계 방지를 목적으로 하며 친수성 또는 이온성 고분자가 도입된 고체 표면은 단백질, 박테리아 등 생물 개체의 부착방지에 효과적이다. 이는 표면에서의 친수층 형성으로 인한 표면 장벽 형성, 고분자 사슬에 의한 반발력과 삼투압성 응력 작용, 그리고 이온성 고분자와 세포 표면의 정전기적 상호작용에 기인한다. 부착억제를 위한 고분자의 표면 도입은 주로 표면 기능기와의 결합을 이용한 접합 방식과 자연모방 접착 기능기를 활용한 침적 방식으로 이루어지고 있다. 본 총설에서는 표면 도입 시 부착억제 기능을 보이는 대표적인 고분자의 종류, 코팅방법, 및 항균 특성을 소개하고 향후 공공시설, 산업 등으로의 대면적 응용을 위한 고려사항들을 다루고자 한다.

Abstract ▼ AI-Helper

The formation of hydrophilic surface based on polymers has received great attention due to the anti-adhesion of bacteria on solid substrates. Anti-adhesion coatings are aimed at suppressing the initial step of biofilm formation via non-cytotoxic mechanisms, and surfaces applied hydrophilic or ionic polymers showed the anti-adhesion effect for bioentities, such as proteins and bacteria. This is attributed to the formation of surface barrier from hydration layers, repulsions and osmotic stresses from polymer brushes, and electrostatic interactions between ionic polymers and cell surfaces. The antifouling polymer coating is usually fabricated by the grafting method through the bonding with functional groups on surfaces and the deposition method utilizing biomimetic anchors. This mini-review is a summary of representative antifouling polymers, coating strategies, and antibacterial efficacy. Furthermore, we will discuss consideration on the large area surface coating for application to public facilities and industry.

주제어

표/그림 (6)

그림 Figure 1. Schematic illustration of the antibacterial adhesion on polymer-brush surfaces.
표 Table 1. Anti-adhesion Efficacy of Polymer-grafted Surfaces
그림 Figure 2. Chemical structures of hydrophilic and zwitterionic polymers for anti-adhesion coating.
그림 Figure 3. Schemes for (a) grafting PEGMA derivative onto oxide substrates, (b) grafting PAAm from ATRP initiator immobilized on aminosilanized substrates, and (c) Quantification of microorganisms adhered to uncoated and PAAm coated silicon wafers. Reprinted with permission from [21], Cringus-Fundeanu et al., Langmuir, 23, 5120 (2007). © 2007, American Chemical Society.
그림 Figure 4. Catechol-conjugated antifouling materials for the anchoring on surfaces.
그림 Figure 5. Schematic illustrations for (a) and (b) the coating of catechol-conjugated materials. Reprinted with permission from [25,15], Cho et al., Langmuir, 35, 14465 (2019). © 2019, American Chemical Society. Kang et al., ACS Sustainable Chem. Eng., 5, 3055 (2017). © 2017, American Chemical Society. Schematic illustrations for (c) and (d) the coating via hydrogen-bonding interactions between antifouling materials and tannic acid on substrates.

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저자의 다른 논문 :

표제어: PCR

동의어: Packet Collision Rate

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용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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