[논문]금속 나노입자의 생체 합성과 항균적 적용

마헤쉬쿠마 프라카쉬 파틸; 김종오; 서용배; 강민재; 김군도

doi:10.5352/jls.2021.31.9.862

금속 나노입자의 생체 합성과 항균적 적용
Biogenic Synthesis of Metallic Nanoparticles and Their Antibacterial Applications 원문보기

생명과학회지 = Journal of life science, v.31 no.9, 2021년, pp.862 - 872

마헤쉬쿠마 프라카쉬 파틸 (부경대학교 산학협력단) , 김종오 (부경대학교 미생물학과) , 서용배 (부경대학교 기초과학연구소) , 강민재 (부경대학교 해양수산생명과학부) , 김군도 (부경대학교 미생물학과)

초록
AI-Helper

최근 생물의학 분야에서의 광범위한 응용 가능성에 의하여 식물이나 미생물을 이용한 은(Ag), 금(Au), 백금(Pt), 세륨(Ce), 아연(Zn), 구리(Cu) 등의 금속 나노물질 합성에 관한 연구가 주목받고 있다. 식물은 플라보노이드, 알칼로이드, 사포닌, 스테로이드 탄닌과 각종 영양 성분과 같은 생리 활성 물질을 풍부하게 가지고 있으며, 유사하게 미생물들도 단백질과 같은 생리활성 대사산물이나 색소, 항생제 및 산과 같은 가치가 있는 화학물질을 분비한다. 최근 보고된 바에 의하면, 나노입자의 생체 합성은 무해한 방법일 뿐만 아니라 항균, 항진균, 세포 증식 억제 및 항플라스모디아 활성과 같은 생물의학 분야로서의 적용에 주요한 후보로 여겨진다. 나노입자의 이러한 생리 활성은 농도에 의존적이며, 나노입자의 모양과 크기에도 따라 달라질 수 있다. 미생물과 식물은 나노입자의 친환경적합성에 사용되는 대사산물이나 화학물질 등의 훌륭한 공급원으로서 생물 의학 분야에서 유용하게 사용된다. 미생물 또는 식물 원료를 사용하여 합성된 나노입자는 화학적인 방법으로 합성된 나노입자보다 더 낮은 독성을 나타낸다. 본 리뷰논문에서는 미생물이나 식물과 같은 생물학적 재료를 이용한 나노입자의 합성과, 합성에 사용되는 다양한 기술의 특성 및 나노입자의 항균 분야에서의 적용에 대하여 중점적으로 서술하였다.

Abstract ▼ AI-Helper

Recent studies on synthesis of metallic nanomaterials such as silver (Ag), gold (Au), platinum (Pt), cerium (Ce), zinc (Zn), and copper (Cu) nanoparticles (NPs) using plants and microbes are attracted researchers for their wide range of applications in the field of biomedical sciences. The plant contains abundant of bioactive contents such as flavonoids, alkaloids, saponins, steroids tannins and nutritionals components. Similarly, microbes produce bioactive metabolites, proteins and secretes valuable chemicals such as color pigments, antibiotics, and acids. Recently reported, biogenic synthesis of NPs in non-hazardous way and are promising candidates for biomedical applications such as antibacterial, antifungal, anti-cell proliferative and anti-plasmodia activity. All those activities are dose dependent, along with their shape and size also matters on potential of NPs. Microbes and plants are great source of metabolites, those useful in biomedical field, such metabolites or chemicals involved in synthesis of NPs in an ecofriendly way. NPs synthesized using microbes or plant materials are reveals more non-toxic, facile, and cost-effective compare to chemically synthesized NPs. In present review we are focusing on NPs synthesis using biological agents such as microbes (bacteria, fungi and algae) and plant, characterization using different techniques and their antibacterial applications on pathogenic Gram-positive and Gram-negative organisms.

주제어

표/그림 (6)

그림 Fig. 1. Schematic presentation of nanoparticles synthesis through physical, chemical and biological method.
그림 Fig. 2. Nanoparticles synthesis by biological method are presented in stepwise order.
표 Table 1. Different type of nanoparticles synthesized using plant materials and their applications
그림 Fig. 3. The diagrammatic presentation of biomedical applications of metallic nanoparticles.
표 Table 2. Different type of nanoparticles synthesized using microorganisms and their applications
표 Table 3. Metallic nanoparticles and their antibacterial effect on pathogenic bacteria

AI 본문요약
AI-Helper

성능/효과

The biogenic NPs are more suitable for biomedical applications due to the tocchemical free nature and shape size can be manipulated or controlled in biogenic process of NPs synthesis. Despite these opportunities, the underlying challenges for biogenic NPs are includes stability of synthesized NPs, formation of nanoclusters, aggregation of nanomaterials and determination of toxicity on animals or environment is still not cleared well. Research on biogenic synthesis of NPs is still ongoing and day-by-day many updated research added in the field of biomedical science and medical science for the use of NPs in human wellness.
Research on biogenic synthesis of NPs is still ongoing and day-by-day many updated research added in the field of biomedical science and medical science for the use of NPs in human wellness. The progress in the growth of nanotechnology and its translation to clinical practices required comprehensive characterization, regulatory guidelines and suitable methods for detection of their toxicity.

참고문헌 (105)

Ahmad, T., Iqbal, J., Bustam, M. A., Zulfiqar, M., Muhammad, N., Al Hajeri, B. M., Irfan, M., Asghar, H. M. A. and Ullah, S. 2020. Phytosynthesis of cerium oxide nanoparticles and investigation of their photocatalytic potential for degradation of phenol under visible light. J. Mol. Struct. 1217, 128292.

상세보기
Al-Radadi, N. S. 2019. Green synthesis of platinum nanoparticles using Saudi's dates extract and their sage on the cancer cell treatment. Arabian J. Chem. 12, 330-349.

상세보기
Al Qhtani, M. S., El-Debaiky, S. A. and Sayed, M. 2020. Antifungal and cytotoxic activities of biosynthesized silver, zinc and gold nanoparticles by flower extract of Rhanterium epapposum. Open J. Appl. Sci. 10, 663.

상세보기
Alsamhary, K. I. 2020. Eco-friendly synthesis of silver nanoparticles by Bacillus subtilis and their antibacterial activity. Saudi J. Biol. Sci. 27, 2185-2191.

상세보기
Amina, M., Al Musayeib, N. M., Alarfaj, N. A., El-Tohamy, M. F. and Al-Hamoud, G. A. 2020. Antibacterial and immunomodulatory potentials of biosynthesized Ag, Au, AgAu bimetallic alloy nanoparticles using the Asparagus racemosus root extract. Nanomaterials 10, 2453.

상세보기
Amro, N. A., Kotra, L. P., Wadu-Mesthrige, K., Bulychev, A., Mobashery, S. and Liu, G. Y. 2000. High-resolution atomic force microscopy studies of the Escherichia coli outer membrane: structural basis for permeability. Langmuir 16, 2789- 2796.

상세보기
Ananda Murthy, H. C., Desalegn, T., Kassa, M., Abebe, B. and Assefa, T. 2020. Synthesis of green copper nanoparticles using medicinal plant Hagenia abyssinica (Brace) JF. Gmel. leaf extract: antimicrobial properties. J. Nanomater. 2020, 3924081.
Applerot, G., Lellouche, J., Lipovsky, A., Nitzan, Y., Lubart, R., Gedanken, A. and Banin, E. 2012. Understanding the antibacterial mechanism of CuO nanoparticles: revealing the route of induced oxidative stress. Small 8, 3326-3337.

상세보기
Arumugam, A., Karthikeyan, C., Haja Hameed, A. S., Gopinath, K., Gowri, S. and Karthika, V. 2015. Synthesis of cerium oxide nanoparticles using Gloriosa superba L. leaf extract and their structural, optical and antibacterial properties. Mater. Sci. Eng. C. 49, 408-415.

상세보기
Arya, A., Gupta, K., Chundawat, T. S. and Vaya, D. 2018. Biogenic synthesis of copper and silver nanoparticles using green alga Botryococcus braunii and its antimicrobial activity. Bioinorg. Chem. Appl. 2018, 7879403.
Asimuddin, M., Shaik, M. R., Fathima, N., Afreen, M. S., Adil, S. F., Siddiqui, R. H., Jamil, K. and Khan, M. 2020. Study of antibacterial properties of Ziziphus mauritiana based green synthesized silver nanoparticles against various bacterial strains. Sustainability 12, 1484.

상세보기
Awad, M. A., Eisa, N. E., Virk, P., Hendi, A. A., Ortashi, K. M., Mahgoub, A. S., Elobeid, M. A. and Eissa, F. Z. 2019. Green synthesis of gold nanoparticles: Preparation, characterization, cytotoxicity, and anti-bacterial activities. Mater. Lett. 256, 126608.

상세보기
Awwad, A. M., Amer, M. W., Salem, N. M. and Abdeen, A. O. 2020. Green synthesis of zinc oxide nanoparticles (ZnO-NPs) using Ailanthus altissima fruit extracts and antibacterial activity. Chem. Int. 6, 151-159.
Aygun, A., Gulbagca, F., Ozer, L. Y., Ustaoglu, B., Altunoglu, Y. C., Baloglu, M. C., Atalar, M. N., Alma, M. H. and Sen, F. 2020. Biogenic platinum nanoparticles using black cumin seed and their potential usage as antimicrobial and anticancer agent. J. Pharm. Biomed. Anal. 179, 112961.

상세보기
Azam, A., Ahmed, A. S., Oves, M., Khan, M. S. and Memic, A. 2012. Size-dependent antimicrobial properties of CuO nanoparticles against Gram-positive and-negative bacterial strains. Int. J. Nanomed. 7, 3527.

상세보기
Azizi, S., Ahmad, M. B., Namvar, F. and Mohamad, R. 2014. Green biosynthesis and characterization of zinc oxide nanoparticles using brown marine macroalga Sargassum muticum aqueous extract. Mater. Lett. 116, 275-277.

상세보기
Borkow, G. and Gabbay, J. 2009. Copper, an ancient remedy returning to fight microbial, fungal and viral infections. Curr. Chem. Biol. 3, 272-278.
Bahrulolum, H., Nooraei, S., Javanshir, N., Tarrahimofrad, H., Mirbagheri, V. S., Easton, A. J. and Ahmadian, G. 2021. Green synthesis of metal nanoparticles using microorganisms and their application in the agrifood sector. J. Nanobiotechnol. 19, 86.

상세보기
Behzadi, S., Ghasemi, F., Ghalkhani, M., Ashkarran, A. A., Akbari, S. M., Pakpour, S., Hormozi-Nazhad, M. R., Jamshidi, Z., Miradeghi, S., Dinarvand, R., Atyabi, F. and Mohmoudi, M. 2015. Determination of nanoparticles using UV-Vis spectra. Nanoscale 7, 5134-5139.

상세보기
Bose, D. and Chatterjee, S. 2015. Antibacterial activity of green synthesized silver nanoparticles using Vasaka (Justicia adhatoda L.) leaf extract. Indian J. Microbiol. 55, 163-167.

상세보기
Castro, L., Blazquez, M. L., Gonzalez, F., Munoz, J. A. and Ballester, A. 2015. Biosynthesis of silver and platinum nanoparticles using orange peel extract: characterisation and applications. IET Nanobiotechnol. 9, 252-258.

상세보기
Chaudhary, R., Nawaz, K., Khan, A. K., Hano, C., Abbasi, B. H. and Anjum, S. 2020. An overview of the algae-mediated biosynthesis of nanoparticles and their biomedical applications. Biomolecules 10, 1498.

상세보기
Chahardoli, A., Karimi, N., Sadeghi, F. and Fattahi, A. 2018. Green approach for synthesis of gold nanoparticles from Nigella arvensis leaf extract and evaluation of their antibacterial, antioxidant, cytotoxicity and catalytic activities. Artif. Cells Nanomed. Biotechnol. 46, 579-588.

상세보기
Choi, J. S., Jung, H. C., Baek, Y. J., Kim, B. Y., Lee, M. W., Kim, H. D. and Kim, S. W. 2021. Antibacterial activity of green-synthesized silver nanoparticles using Areca catechu extract against antibiotic-resistant bacteria. Nanomaterials 11, 205.

상세보기
Dhamecha, D., Jalalpure, S. and Jadhav, K. 2016. Nepenthes khasiana mediated synthesis of stabilized gold nanoparticles: characterization and biocompatibility studies. J. Photochem. Photobiol. B 154, 108-117.

상세보기
Du, L., Xian, L. and Feng, J. X. 2011. Rapid extra-/intracellular biosynthesis of gold nanoparticles by the fungus Penicillium sp. J. Nanopart. Res. 13, 921-930.

상세보기
Es-Haghi, A., Taghavizadeh Yazdi, M. E., Sharifalhoseini, M., Baghani, M., Yousefi, E., Rahdar, A. and Baino, F. 2021. Application of response surface methodology for optimizing the therapeutic activity of ZnO nanoparticles biosynthesized from Aspergillus niger. Biomimetics 6, 34.

상세보기
Fahmy, S. A., Preis, E., Bakowsky, U. and Azzazy, H. M. E. 2020. Platinum nanoparticles: green synthesis and biomedical applications. Molecules 25, 4981.

상세보기
Gaidhani, S. V., Yeshvekar, R. K., Shedbalkar, U. U., Bellare, J. H. and Chopade, B. A. 2014. Bio-reduction of hexachloroplatinic acid to platinum nanoparticles employing Acinetobacter calcoaceticus. Process Biochem. 49, 2313-2319.

상세보기
Gordon, T., Perlstein, B., Houbara, O., Felner, I., Banin, E. and Margel, S. 2011. Synthesis and characterization of zinc/iron oxide composite nanoparticles and their antibacterial properties. Colloids Surf. A 374, 1-8.

상세보기
Guilger-Casagrande, M. and Lima, R. D. 2019. Synthesis of silver nanoparticles mediated by fungi: a review. Front. Bioeng. Biotechnol. 7, 287.

상세보기
Hulkoti, N. I. and Taranath, T. C. 2014. Biosynthesis of nanoparticles using microbes-a review. Colloids Surf. B 121, 474-483.

상세보기
Iravani, S., Korbekandi, H., Mirmohammadi, S. V. and Zolfaghari, B. 2014. Synthesis of silver nanoparticles: chemical, physical and biological methods. Res. Pharm. Sci. 9, 385.

상세보기
Jadoun, S., Arif, R., Jangid, N. K. and Meena, R. K. 2021. Green synthesis of nanoparticles using plant extracts: a review. Environ. Chem. Lett. 19, 355-374.

상세보기
Javadi, F., Yazdi, M. E. T., Baghani, M. and Es-haghi, A. 2019. Biosynthesis, characterization of cerium oxide nanoparticles using Ceratonia siliqua and evaluation of antioxidant and cytotoxicity activities. Mater. Res. Express 6. 065408.

상세보기
Jayabalan, J., Mani, G., Krishnan, N., Pernabas, J., Devadoss, J. M. and Jang, H. T. 2019. Green biogenic synthesis of zinc oxide nanoparticles using Pseudomonas putida culture and its In vitro antibacterial and anti-biofilm activity. Biocatal. Agric. Biotechnol. 21, 101327.

상세보기
Jeyapaul, U., Kala, M. J., Bosco, A. J., Piruthiviraj, P. and Easuraja, M. 2018. An eco-friendly approach for synthesis of platinum nanoparticles using leaf extracts of Jatropa grossypifolia and Jatropa glandulifera and its antibacterial activity. Orien. J. Chem. 34, 783-790.

상세보기
Kairyte, K., Kadys, A. and Luksiene, Z. 2013. Antibacterial and antifungal activity of photoactivated ZnO nanoparticles in suspension. J. Photochem. Photobiol. B 128, 78-84.

상세보기
Kannan, S. K. and Sundrarajan, M. 2014. A green approach for the synthesis of a cerium oxide nanoparticle: characterization and antibacterial activity. Int. J. Nanosci. 13, 1450018.

상세보기
Khodashenas, B. and Ghorbani, H. R. 2019. Synthesis of silver nanoparticles with different shapes. Arabian J. Chem. 12, 1823-1838.

상세보기
Klaus, T., Joerger, R., Olsson, E. and Granqvist, C. G. 1999. Silver-based crystalline nanoparticles, microbially fabricated. Proc. Natl. Acad. Sci. USA. 96, 13611-13614.

상세보기
Kolahalam, L. A., Viswanath, I. K., Diwakar, B. S., Givindh, B., Reddy, V. and Murthy, Y. L. N. 2019. Review on nanomaterials: synthesis and applications. Mater. Today: Proc. 18, 2182-2190.

상세보기
Krithiga, N., Rajalakshami, A. and Jayachitra, A. 2015. Green synthesis of silver nanoparticles using leaf extract of Clitoria ternatea and Solanum nigrum and study of its antibacterial effect against common nosocomial pathogens. J. Nanosci. 2015, 928204.
Kuppusamy, P., Yusoff, M. M., Maniam, G. P. and Govindan, N. 2016. Biosynthesis of metallic nanoparticles using plant derivatives and their new avenues in pharmacological applications - An updated report. Saudi Pharm. J. 24, 473-484.

상세보기
Lee, S. Y., Krishnamurthy, S., Cho, C. W. and Yun, Y. S. 2016. Biosynthesis of gold nanoparticles using Oscimum sanctum extracts with different polarity. ACS Sustain. CHem. Eng. 4, 2651-2659.
Li, G. R., Xu, H., Lu, X. F., Feng, J. X., Tong, Y. X. and Su, C. Y. 2013. Electrochemical synthesis of nanostructured materials for electrochemical energy conversion and storage. Nanoscale 5, 4056-4069.

상세보기
Luksiene, Z. 2017. Nanoparticles and their potential application as antimicrobials in the food industry. In Food Preservation (pp. 567-601). Academic press.
Mali, S. C., Dhaka, A., Githala, C. K. and Trivedi, R. 2020. Green synthesis of copper nanoparticles using Celastrus paniculatus Willd. leaf extract and their photocatalytic and anti-fungal properties. Biotechnol. Rep. (Amst) 27, e00518.
Markus, J., Mathiyalagan, R., Kim, Y. J., Abbai, R., Singh, P., Ahn, S., Perez, Z. E. J., Hurh, J. and Yang, D. C. 2016. Intracellular synthesis of gold nanoparticles with antioxidant activity by probiotic Lactobacillus kimchicus DCY51T isolated from Korean kimchi. Enzyme Microb. Technol. 95, 85-93.

상세보기
Mata, R., Nakkala, J. R. and Sadras, S. R. 2016. Polyphenol stabilized colloidal gold nanoparticles from Abutilon indicum leaf extract induces apoptosis in HT-29 colon cancer cells. Colloids Surf., B 143, 499-510.

상세보기
Maqbool, Q., Nazar, M., Naz, S., Hussain, T., Jabeen, N., Kausar, R., Anwaar, S., Abbas, F. and Jan, T. 2016. Antimicrobial potential of green synthesized CeO2 nanoparticles from Olea europaea leaf extract. Int. J. Nanomed. 11, 5015.

상세보기
Mollick, M. M. R., Rana, D., Dash, S. K., Chattopadhyay, S., Bhowmick, B., Maity, D., Mondal, D., Pattanayak, S., Roy, S., Chakraborty, M. and Chattopadhyay, D. 2019. Studies on green synthesized silver nanoparticles using Abelmoschus esculentus (L.) pulp extract having anticancer (in vitro) and antimicrobial applications. Arabian J. Chem. 12, 2572-2584.

상세보기
Morones, J. R., Elechiguerra, J. L., Camacho, A., Holt, K., Kouri, J. B. and Yacaman, M. J. 2005. The bactericidal effect of silver nanoparticles. Nanotechnology 16, 2346-2353.

상세보기
Muthuvel, A., Jothibas, M., Mohana, V. and Manoharan, C. 2020. Green synthesis of cerium oxide nanoparticles using Calotropis procera flower extract and their photocatalytic degradation and antibacterial activity. Inorg. Chem. Commun. 119, 108086.

상세보기
Nadeem, M., Khan, R., Afridi, K., Nadhman, A., Ullah, S., Faisal, S., Mabood, Z. U., Hano, C. and Abbasi, B. H. 2020. Green synthesis of cerium oxide nanoparticles (CeO2 NPs) and their antimicrobial applications: a review. Int. J. Nanomed. 15, 5951.

상세보기
Ozturk, B. Y., Gursu, B. Y. and Dag, I. 2020. Antibiofilm and antimicrobial activities of green synthesized silver nanoparticles using marine red algae Gelidium corneum. Process Biochem. 89, 208-219.

상세보기
Patil, M. P. and Kim, G. D. 2017. Eco-friendly approach for nanoparticles synthesis and mechanism behind antibacterial activity of silver and anticancer activity of gold nanoparticles. Appl. Microbiol. Biotechnol. 101, 79-92.

상세보기
Patil, M. P. and Kim, G. D. 2018. Marine microorganisms for synthesis of metallic nanoparticles and their biomedical applications. Colloids Surf., B 172, 487-495.

상세보기
Patil, M. P. and Kim, G. D. 2020. Microorganisms-mediated functionalization of nanoparticles for different applications. pp. 279-298. In: Kumar, V., Guleria, P., Dasgupta, N. and Ranjan, S. (eds.), Functionalized Nanomaterials I: Fabrications. CRC Press, Taylor and Francis group.
Patil, M. P., Bayaraa, E., Subedi, P., Piad, L. L. A., Tarte, N. H. and Kim, G. D. 2019. Biogenic synthesis, characterization of gold nanoparticles using Lonicera japonica and their anticancer activity on HeLa cells. J. Drug Deliv. Sci. Technol. 51, 83-90.

상세보기
Patil, M. P., Kang, M. J., Niyonizigiye, I., Singh, A., Kim, J. O., Seo, Y. B. and Kim, G. D. 2019. Extracellular synthesis of gold nanoparticles using the marine bacterium Paracoccus haeundaensis BC74171T and evaluation of their antioxidant and antiproliferative effect on normal and cancer cell lines. Colloids Surf., B 183, 110455.

상세보기
Patil, M. P., Rokade, A. A., Ngabire, D. and Kim, G. D. 2016. Green synthesis of silver nanoparticles using water extract from galls of Rhus chinensis and its antibacterial activity. J. Clust. Sci. 27, 1737-1750.

상세보기
Patil, M. P., Seo, Y. B. and Kim, G. D. 2016. Morphological changes of bacterial cells upon exposure of silver-silver chloride nanoparticles synthesized using Agrimonia pilosa. Microb. Pathog. 116, 84-90.

상세보기
Patil, M. P., Singh, R. D., Koli, P. B. Patil, K. T., Jagadale, B. S., Tipare, A. R. and Kim, G. D. 2018. Antibacterial potential of silver nanoparticles synthesized using Madhuca longifolia flower extract as a green resource. Microb. Pathog. 121, 184-189.

상세보기
Perveen, K., Husain, F. M., Qais, F. A., Khan, A., Razak, S., Afsar, T., Alam, P., Almajwal, A. M. and Abulmeaty, M. 2021. Microwave-assisted rapid green Synthesis of gold nanoparticles using seed extract of Trachyspermum ammi: ROS mediated biofilm inhibition and anticancer activity. Biomolecules 11, 197.

상세보기
Pitchumani, K. M. and Annadurai, G. 2019. Biosynthesis of nanoceria from Bacillus subtilis: characterization and antioxidant potential. Res. J. Life Sci. 5, 644.
Poinern, G. E. J. 2014. A laboratory course in nanoscience and nanotechnology, 1st edn. CRC press, Taylor and Francis Group, Boca Raton.
Punniyakotti, P., Panneerselvam, P., Perumal, D., Aruliah, R. and Angaiah, S. 2020. Anti-bacterial and anti-biofilm properties of green synthesized copper nanoparticles from Cardiospermum halicacabum leaf extract. Bioprocess Biosyst. Eng. 43, 1649-1657.

상세보기
Rad, S. S., Sani, A. M. and Mohseni, S. 2019. Biosynthesis, characterization and antimicrobial activities of zinc oxide nanoparticles from leaf extract of Mentha pulegium (L.). Microb. Pathog. 131, 239-245.

상세보기
Rajan, A., Rajan, A. R. and Philip, D. 2017. Elettaria cardamomum seed mediated rapid synthesis of gold nanoparticles and its biological activities. OpenNano 2, 1-8.

상세보기
Rajesh, K. M., Ajitha, B., Reddy, Y. A. K., Suneetha, Y. and Reddy, P. S. 2018. Assisted green synthesis of copper nanoparticles using Syzygium aromaticum bud extract: Physical, optical and antimicrobial properties. Optik 154, 593-600.

상세보기
Rambabu, K., Bharath, G., Banat, F. and Show, P. L. 2021. Green synthesis of zinc oxide nanoparticles using Phoenix dactylifera waste as bioreductant for effective dye degradation and antibacterial performance in wastewater treatment. J. Hazard. Mater. 402, 123560.

상세보기
Ramanathan, R., Field, M. R., O'Mullane, A. P., Smooker, P. M., Bhargava, S. K. and Bansal, V. 2013. Aqueous phase synthesis of copper nanoparticles: a link between heavy metal resistance and nanoparticle synthesis ability in bacterial system. Nanoscale 21, 2300-2306.
Ramkumar, V. S., Pugazhendhi, A., Prakash, S., Ahila, N. K., Vinoj, G., Selvam, S., Kumar, G., Kannapiran, E. and Rajendran, R. B. 2017. Synthesis of platinum nanoparticles using seaweed Padina gymnospora and their catalytic activity as PVP/PtNPs nanocomposite towards biological applications. Biomed. Pharmacother. 92, 479-490.

상세보기
Reddy, K. M., Feris, K., Bell, J., Wingett, D. G., Hanley, C. and Punnoose, A. 2007. Selective toxicity of zinc oxide nanoparticles to prokaryotic and eukaryotic systems. Appl. Phys. Lett. 90, 213902.

상세보기
Riddin, T. L., Gericke, M. and Whiteley, C. G. 2006. Analysis of the inter- and extracellular formation of platinum nanoparticles by Fusarium oxysporum f. sp. lycopersici using response surface methodology. Nanotechnology 17, 3482.

상세보기
Saif Hasan, S., Singh, S., Parikh, R. Y., Dharne, M. S., Patole, M. S., Prasad, B. L. V. and Shouche, Y. S., 2008. Bacterial synthesis of copper/copper oxide nanoparticles. J. Nanosci. Nanotechnol. 8, 3191-3196.

상세보기
Sakamoto, M., Fujistuka, M. and Majima, T. 2009. Light as a construction tool of metal nanoparticles: synthesis and mechanism. J. Photochem. Photobiol. C 10, 33-56.

상세보기
Salem, S. S. and Fouda, A. 2021. Green synthesis of metallic nanoparticles and their prospective biotechnological applications: an overview. Biol. Trace Elem. Res. 199, 344-370.

상세보기
Salvadori, M. R., Ando, R. A., Oller do Nascimento, C. A. and Correa, B. 2014. Intracellular biosynthesis and removal of copper nanoparticles by dead biomass of yeast isolated from the wastewater of a mine in the Brazilian Amazonia. PLoS One 9, e87968.

상세보기
Sanaeimehr, Z., Javadi, I. and Namvar, F. 2018. Antiangiogenic and antiapoptotic effects of green-synthesized zinc oxide nanoparticles using Sargassum muticum algae extraction. Cancer Nanotechnol. 9, 1-16.

상세보기
Saratale, R. G., Saratale, G. D., Shin, H. S., Jacob, J. M., Pugazhendhi, A., Bhaisare, M. and Kumar, G. 2018. New insights on the green synthesis of metallic nanoparticles using plant and waste biomaterials: current knowledge, their agricultural and environmental applications. Environ. Sci. Pollut. Res. 25, 10164-10183.

상세보기
Saravanan, M., Barik, S. K., MubarakAli, D., Prakash, P. and Pugazhendhi, A. 2018. Synthesis of silver nanoparticles from Bacillus brevis (NCIM 2533) and their antibacterial activity against pathogenic bacteria. Microb. Pathog. 116, 221-226.

상세보기
Senapati, S., Syed, A., Moeez, S., Kumar, A. and Ahmad, A. 2012. Intracellular synthesis of gold nanoparticles using alga Tetraselmis kochinensis. Mater. Lett. 79, 116-118.

상세보기
Shafey, A. M. E. 2020. Green synthesis of metal and metal oxide nanoparticles from plant leaf extracts and their applications: a review. De Gruyter 9, 304-339.
Sharmila, G., Muthukumaran, C., Saraswathi, H., Sangeetha, E., Soundarya, S. and Kumar, N. M. 2019. Green synthesis, characterization and biological activities of nanoceria. Ceram. Int. 45, 12382-12386.

상세보기
Shende, S., Ingle, A. P., Gade, A. and Rai, M. 2015. Green synthesis of copper nanoparticles by Citrus medica Linn. (Idilimbu) juice and its antimicrobial activity. World J. Microb. Biotechnol. 31, 865-873.

상세보기
Singh, P., Kim, Y. J., Zhang, D. and Yang, D. C. 2016. Biological synthesis of nanoparticles from plants and microorganisms. Trends Biotechnol. 34, 588-599.

상세보기
Sisubalan, N., Ramkumar, V. S., Pugazhendhi, A., Karthikeyan, C., Indira, K., Gopinath, K., Hameed, A. S. H. and Basha, M. H. G. 2017. ROS-mediated cytotoxic activity of ZnO and CeO 2 nanoparticles synthesized using the Rubia cordifolia L. leaf extract on MG-63 human osteosarcoma cell lines. Environ. Sci. Pollut. Res. 25, 10482-10492.
Srivastava, S., Usmani, Z., Atanasov, A. G., Singh, V. K., Singh, N. P., Abdel-Azeem, A. M., Prasad, R., Gupta, G., Sharma, M. and Bhargava, A. 2021. Biological nanofactories: using living forms for metal nanoparticle synthesis. MiniRev. Med. Chem. 21, 245-265.

상세보기
Su, D. 2017. Advanced elctron microscopy characterization of nanomaterials for catalysis. Green Energy Environ. 2, 70-83.

상세보기
Sukhanova, A., Bozrova, S., Sokolov, P., Berestovoy, M., Karaulov, A. and Nabiev, I. 2018. Dependence of nanoparticles toxicity on their physical and chemical properties. Nanoscle Res. Lett. 13, 44.

상세보기
Sumanth, B., Lakshmeesha, T. R., Ansari, M. A., Alzohairy, M. A., Udayashankar, A. C., Shobha, B., Niranjana, S. R., Srinivas, C. and Almatroudi, A. 2020. Mycogenic synthesis of extracellular zinc oxide nanoparticles from Xylaria acuta and its nanoantibiotic potential. Int. J. Nanomed. 15, 8519.

상세보기
Tahir, K., Nazir, S., Ahmad, A., Li, B., Khan, A. U., Khan, Z. U. H., Khan, F. U., Khan, Q. U., Khan, A. and Rahman, A. U. 2017. Facile and green synthesis of phytochemicals capped platinum nanoparticles and in vitro their superior antibacterial activity. J. Photochem. Photobiol. B 166, 246-251.

상세보기
Tomaszewska, E., Soliwoda, K., Kadziola, K., Tkacz-Szczesna, B., Celichowski, G., Cichomski, M., Szmaja, W. and Grobelny, J. 2013. Detection limit of DLS and VU-vis spectroscopy in characterization of polydisperse nanoparticles colloids. J. Nanomater. 2013, 313081.
Tripathi, R. M. and Chung, S. J. 2019. Biogenic nanomaterials: synthesis, characterization, and biomedical applications. J. Microbiol. Methods 157, 65-80.

상세보기
Tyagi, S., Tyagi, P. K., Gola, D., Chauhan, N. and Bharti, R. K. 2019. Extracellular synthesis of silver nanoparticles using entomopathogenic fungus: characterization and antibacterial potential. SN Appl. Sci. 1, 1-9.
Umar, H., Kavaz, D. and Rizaner, N. 2019. Biosynthesis of zinc oxide nanoparticles using Albizia lebbeck stem bark, and evaluation of its antimicrobial, antioxidant, and cytotoxic activities on human breast cancer cell lines. Int. J. Nanomed. 14, 87-100.

상세보기
Uzair, B., Liaqat, A., Iqbal, H., Menaa, B., Razzaq, A., Thiripuranathar, G., Fatima Rana, N. and Menaa, F. 2020. Green and cost-effective synthesis of metallic nanoparticles by algae: Safe methods for translational medicine. Bioengineering 7, 129.

상세보기
Venkatesh, K. S., Gopinath, K., Palani, N. S., Arumugam, A., Jose, S. P., Bahadur, S. A. and Ilangovan, R. 2016. Plant pathogenic fungus F. solani mediated biosynthesis of nanoceria: antibacterial and antibiofilm activity. RSC Adv. 6, 42720-42729.

상세보기
Wu, S., Rajeshkumar, S., Madasamy, M. and Mahendran, V. 2020. Green synthesis of copper nanoparticles using Cissus vitiginea and its antioxidant and antibacterial activity against urinary tract infection pathogens. Artif. Cells Nanomed. Biotechnol. 48, 1153-1158.

상세보기
Xia, T., Kovochich, M., Liong, M., Madler, L., Gilbert, B., Shi, H., Yeh, J. I., Zink, J. I. and Nel, A. E. 2008. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano. 2, 2121-2134.

상세보기
Zhang, D., Ma, X. L., Gu, Y., Huang, H. and Zhang, G. W. 2020. Green synthesis of metallic nanoparticles and their potential applications to treat cancer. Front. Chem. 8, 799.

상세보기
Zhang, L., Ding, Y., Povey, M. and York, D. 2008. ZnO nanofluids-A potential antibacterial agent. Prog. Nat. Sci. 18, 939-944.

상세보기
Zhang, Q., Kusada, K. and Kitagawa, H. 2021. Phase control of noble monometallic and alloy nanomaterials by chemical reduction methods. ChemPlusChem 86, 504-519.

상세보기

저자의 다른 논문 :

표제어: PCR

동의어: Packet Collision Rate

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용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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