[논문]골다공증 다빈도 처방과 구성 약물의 네트워크 분석 - 오아시스 검색을 중심으로

신선미; 고흥

doi:10.22246/jikm.2021.42.4.628

[국내논문] 골다공증 다빈도 처방과 구성 약물의 네트워크 분석 - 오아시스 검색을 중심으로
Network Analysis of Herbs that are Frequently Prescribed for Osteoporosis with a Focus on Oasis Platform Research 원문보기

대한한방내과학회지 = The journal of internal Korean medicine, v.42 no.4, 2021년, pp.628 - 644

신선미 (세명대학교 한의과대학 한방내과학교실) , 고흥 (세명대학교 한의과대학 한방내과학교실)

Abstract ▼ AI-Helper

Objectives: This study analyzed, through network analysis and data mining analysis, the relationship between herbs used in osteoporosis prescriptions, diversified the analysis of osteoporosis-related prescriptions, and analyzed the combination of herbs used in osteoporosis-related prescriptions. Methods: The prescriptions used in osteoporosis treatment and experiments were established by conducting a full survey of the papers published by the OASIS site. A database for osteoporosis-related prescriptions was established, herbs were extracted, and the frequency of frequent herbs and prescriptions were investigated using Excel (MS offices ver. 2013). Using the freeware R version 4.0.3 (2020-10-10), igraph, and arules package, network analysis was performed in the first second of prescription composition. Results: Among the osteoporosis-related prescriptions, the most studied prescriptions are as follows.: Yukmijihwang-tang (六味地黃湯) and Samul-tang (四物湯). In the osteoporosis prescription network, herbs with connection centrality, proximity centrality, mediation centrality, and eigenvector centrality appeared in the order of Rehmanniae Radix Preparata, Angelicae Gigantis Radix, Poria Sclerotium, Paeoniae Radix, and Glycyrrhizae Radix et Rhizoma. After extracting the herbal combination network, including the corresponding herbs, and clustering it, it can be divided into drugs of the Yukmijihwang-tang (六味地黃湯) series and the Samul-tang (四物湯). Conclusions: This study could assist researchers in diversifyingy formula analysis in future studies. Moreover, the herbal combination used in osteoporosis prescriptions could be used to search for osteoporosis prescriptions in other databases or to create a new prescription.

Keyword

표/그림 (13)

그림 Fig 1. The study screening flow chart.
표 Table 1. Prescription and Herb in Korean Medicine for Osteoporosis Studies from OASIS
표 Table 2. Frequency on Medicinal Materials in Korean Medicine for Osteoporosis
표 Table 3. Frequency on Herbal Combinations in Korean Medicine for Osteoporosis
표 Table 4. Top of Degree Centrality Analysis in Herbs used in Korean Medicine for Osteoporosis
표 Table 5. Top 20 of Closeness Centrality Analysis in Herbs Used in Korean Medicine for Osteoporosis
표 Table 6. Top 20 of Degree Betweenness Centrality Analysis in Herbs Used in Korean Medicine for Osteoporosis
표 Table 7. Top 20 of Degree Eigenvector Centrality Analysis in Herbs Used in Korean Medicine for Osteoporosis
그림 Fig. 2. Network diagram for herbs used in Korean medicine for osteoporosis. Minimum support 0.07, minimum confidence 0.9
표 Table 8. The Groups of Network Analysis for Herbs Used in Korean Medicine for Osteoporosis
표 Table 9. Herbal Combinations by Association Analysis
그림 Fig. 3. Network diagram for herbs used in Korean medicine for osteoporosis using Apriori algorithm. Minimum support 0.07, minimum confidence 0.9
표 Table 10. The groups of Network Analysis Using Apriori Algorithm for Herbs Used in Korean Medicine for Osteoporosis

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