[논문]류마티스 관절염에서 NLRP3 인플라마좀의 역할

김현진; 정수현; 이준호; 김대용; 양갑식

류마티스 관절염에서 NLRP3 인플라마좀의 역할
Role of NLRP3 Inflammasome in Rheumatoid Arthritis 원문보기

대한융합한의학회지 = Journal of Convergence Korean Medicine, v.4 no.1, 2022년, pp.5 - 11

김현진 (우석대학교) , 정수현 (우석대학교) , 이준호 (우석대학교) , 김대용 (우석대학교) , 양갑식 (우석대학교)

Abstract ▼ AI-Helper

Objectives: Inflammasomes are molecular platforms that are generated inside cytoplasmic compartments. The objective is to mediate immunological responses of the host to cell damage and infection. Caspase-1 is triggered by inflammasome to generate interleukin-1𝛽 (IL-1𝛽), an inflammatory cytokine, and pyroptosis, an inflammatory form of apoptosis. Methods: In the past two decades, scientists have uncovered several inflammasomes. The most research has been conducted on NLRP3 inflamamsomes, whose activity can be stimulated by a variety of induction factors. However, the unregulated activation of NLRP3 inflammasomes is also a role in the etiology of several human disorders. Previous research has demonstrated that NLRP3 inflammasomes have a significant role in the innate and acquired immune systems, as well as in the prevalence of joint illnesses such rheumatoid arthritis. Conclusion: Within the scope of this review, we will present a brief overview of the biological features of NLRP3 inflamamsomes as well as a description of the underlying mechanisms governing activation and regulation. In particular, we explore the function of inflammasomes in the development of rheumatoid arthritis as well as the promise of recently identified medicines that target inflamasomes.

주제어

표/그림 (1)

그림 Figure 1. The main NLRP3 inflammasomes. The canonical NLRP3 inflammasome needs a priming signal, also called Signal 1, which is often sent by toll-like receptors (TLRs) and turns on NF-kB, which makes NLRP3 proteins. PAMPs or DAMPs send an activating signal, which is also called Signal 2. PAMPs and DAMPs cause changes in the cell's physiology. These changes show up as ion efflux and influx, mitochondrial dysfunction, or the phagosome bursting. These changes in physiology are picked up by NLRP3, which tells the kinase NEK7, ASC, and caspase-1 to put together the NLRP3 inflammasome.

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표제어: PCR

동의어: Packet Collision Rate

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용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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