[논문]비트 추출물의 암세포 증식 저해 효과

이재혁; 박정숙

doi:10.15207/jkcs.2022.13.02.257

비트 추출물의 암세포 증식 저해 효과
Inhibitory Effect of Beet Extract on Cancer Cell Proliferation 원문보기

한국융합학회논문지 = Journal of the Korea Convergence Society, v.13 no.2, 2022년, pp.257 - 262

초록
AI-Helper

본 연구의 목적은 다양한 생리활성물질을 함유한 비트 추출물의 다양한 농도를 이용하여 인체 유래 암세포 증식 저해를 살펴보기 위하여 실시하였다. 실험에 사용한 인체 유래 암세포는 6종으로 전립샘암세포 DU145, 폐암세포 A549, 유방암세포 MCF-7, 자궁암세포 HeLa, 간암세포 SNU-182, 담도암세포 SNU-1196을 사용하였으며, 비트 추출물의 다양한 농도에 대한 암세포증식 저해를 CCK-8 방법으로 측정하였다. 암세포증식 저해를 살펴본 결과 비트 추출물은 전립샘암세포 DU145를 모든 농도에서 유의성있게 농도 의존적으로 저해하였으며, 폐암세포 A549, 전립샘암세포 DU-145는 100ug/mL, 1000ug/mL에서 자궁암세포 HeLa, 간암세포 SNU-182, 담도암세포 SNU-1196는 1000ug/mL에서 유의한 증식 저해를 보였다. 실험 결과, 다양한 인체 유래 암세포를 이용한 비트 추출물의 암세포증식 저해는 암 예방 효과 및 기능성 식품 개발의 가능성을 제공한다고 볼 수 있다.

Abstract ▼ AI-Helper

The purpose of this study was to examine the inhibition of human cancer cell proliferation by using various concentrations of Beet Extract containing various bioactive ingredients. The six cancer cell lines used in the experiment were prostate cancer cells DU-145, lung cancer cells A549, breast cancer cells MCF-7, cervical cancer cells HeLa, liver cancer cells SNU-182, and biliary tract cancer cells SNU-1196. Human-derived cancer cell lines were used. The inhibition of cancer cell proliferation at various concentrations of Beet Extract was measured by the CCK-8 method. As a result of examining the inhibition of cancer cell proliferation, Beet Extract significantly and concentration-dependently inhibited DU145 of prostate cancer cells at all concentrations, and Lung cancer cells A549 and DU-145 of prostate cancer cells at 100ug/mL and 1000ug/mL, cervical cancer cells HeLa, and liver cancer cells SNU- 182, biliary tract cancer cell SNU-1196 showed significant proliferation inhibition at 1000ug/mL. Experiment result, the cancer cell proliferation inhibitory mechanisms of Beet Extract using various human-derived cancer cell lines can be considered to provide cancer prevention effects and the possibility of developing functional foods.

주제어

표/그림 (6)

그림 Fig. 1. Inhibitory effect of Beet Extract on human prostate cancer cell DU-145. *: p<0.05 significant effect between the control group and each extract group
그림 Fig. 2. Inhibitory effect of Beet Extract on human lung cancer cell A549. *: p<0.05 significant effect between the control group and each extract group
그림 Fig. 3. Inhibitory effect of Beet Extract on human breast cancer cell MCF-7 *: p<0.05 significant effect between the control group and each extract group
그림 Fig. 4. Inhibitory effect of Beet Extract on human cervical cancer cell HeLa. *: p<0.05 significant effect between the control group and each extract group.
그림 Fig. 5. Inhibitory effect of Beet Extract on human liver cancer cell SNU-182. *: p<0.05 significant effect between the control group and each extract group.
그림 Fig. 6. Inhibitory effect of Beet Extract on human biliary tract cancer SNU-1196. *: p<0.05 significant effect between the control group and each extract group

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