[논문]진드기의 수분조절 생리와 진드기 방제전략

말도나도-루이즈 폴리나; 김동흔; 박윤성

doi:10.5656/ksae.2022.02.0.005

진드기의 수분조절 생리와 진드기 방제전략
Osmoregulatory Physiology in Ixodidae Ticks: An Alternative Target for Management of Tick 원문보기

한국응용곤충학회지 = Korean journal of applied entomology, v.61 no.1, 2022년, pp.91 - 100

말도나도-루이즈 폴리나 (캔자스주립대학교 곤충학과) , 김동흔 (경북대학교 질병매개곤충학과) , 박윤성 (캔자스주립대학교 곤충학과)

초록
AI-Helper

진드기는 박테리아, 바이러스, 원생동물 및 균류를 포함한 다양한 병원체를 전달할 수 있는 감염병매개체이다. 진드기는 불리한 환경조건에서도 생존할 수 있는 능력이 있으며, 흡혈이 필수적인 절지동물의 진화적 산물로써 비흡혈 기간이 장기간 지속되는 경우에도 생존이 가능하다. 특히, 높은 온도와 낮은 습도 환경에서도 견딜 수 있는 수분 조절 메커니즘과 내열성의 생리적 특징은 진드기가 전 세계적으로 분포하도록 한 중요한 요인이다. 진드기의 침샘, 말피기관, 후장 그리고 뇌를 포함하는 여러 기관이 관여하는 물과 이온의 획득 및 배출은 복합적인 메커니즘에 의해 조절된다. 진드기가 수분을 확보하는 주요 경로는 흡혈과정 또는 공기 중 수증기를 직접 포집하는 방식이며, 이와 더불어 진드기가 자연조건에서 맺힌 물방울을 직접 마시며 수분을 보충한다는 것이 최근 본 연구진의 연구를 통해 밝혀졌다. 물방울에서 획득된 수분은 진드기 침샘의 포도상 부위(유형 I) 또는 중장을 통해 체내로 흡수된다는 것이 형광물질 추적을 통해 확인되었다. 이 연구 결과는 진드기 방제 및 병원체 전파 억제를 위한 전략 개발에 새로운 방향을 제시하였다. 본 종설에서는 진드기 방제를 위한 잠재적 표적인 진드기의 수분조절 및 표피 배설의 생리적 메커니즘을 종합적으로 다룬다.

Abstract ▼ AI-Helper

Ticks are the arthropod vector capable of transmitting diverse pathogens, which include bacteria, viruses, protozoan and fungi. Ticks are able to survive under stressful environmental conditions. One of evolutionary outcomes of these obligatory hematophagous arthropods is the survival for extended periods of time without a blood meal during off-host periods. Water conservation biology and heat tolerance have allowed ticks to thrive even under high temperatures and low relative humidity, thus they have become highly successful arthropods as they are distributed globally. Tick osmoregulatory physiology is a complex mechanism, which involves multiple osmoregulatory organs (salivary glands, Malpighian tubules, hindgut and synganglion) for the acquisition and excretion of water and ions. Blood feeding and water vapor uptake have been early reported as the primary passages for ixodid tick to acquire water. Recently, we have learned that ticks can actively drink environmental water allowing hydration. The acquired water can be traced to the salivary glands (type I acini) and the midgut diverticula. This opens new avenues for tick management through the delivery of toxic agents into their drinking water, in addition to an alternative strategy for the study of tick physiology. Here we address the osmoregulatory physiology in the ixodid ticks as a potential target physiological mechanism for tick control. We discuss the implications of water drinking behavior for tick control through the delivery of toxic agents and discuss the dermal excretion physiology as an additional pathway to induce tick dehydration and tick death.

주제어

표/그림 (2)

그림 Fig. 1. Schematic representation of water uptake in metastriate ticks and main osmoregulatory organs. (A) Representation of vapor uptake through the secretion of hygroscopic saliva (a1 in yellow) in low relative humidity (RH) and (B) hyperosmolar saliva capturing water molecules from the environment (blue) for rehydration. (C) Voluntary water drinking behavior in unfedA. americanum (D) and I. scapularis (Kim et al., 2017). (E) Anatomy of hard ticks, showing the major internal organs. salivary glands (blue) and (c1) type I, II and type III acini, synganglion (pink), hindgut (green), and Malpighian tubules (yellow tubular ducts) and (F) the different types of salivary gland acini in hard ticks (modified from Kim et al., 2017).
그림 Fig. 2. Dermal glands in A. americanum and dermal secretion. (A) Compound microscope image from tick sections stained with methylene blue and eosin (Magenta square shows the dermal gland type I and the pore and (B) type II dermal gland and pore outlined by a blue square. (C) Dermal secretion in A. americanum female adult after hot environment simulation (incubator temperature 50°C). (D) Inset of C. (E) Response of dermal secretion after injection with 10 nl of serotonin (20 minutes after pre-injection with Ouabain (Na⁺-/K⁺--ATPase blocker), or water (controls)).

참고문헌 (70)

Abbas, R.Z., Zaman, M.A., Colwell, D.D., Gilleard, J., Iqbal, Z., 2014. Acaricide resistance in cattle ticks and approaches to its management: The state of play. Vet. Parasitol. 203, 6-20.

상세보기
Albers, M.A., Bradley, T.J., 2004. Osmotic regulation in adult Drosophila melanogaster during dehydration and rehydration. J. Exp. Biol. 207, 2313-2321

상세보기
Benoit, J.B., Denlinger, D.L., 2010. Meeting the challenges of onhost and off-host water balance in blood-feeding arthropods. J. Insect. Physiol. 56, 1366-1376.

상세보기
Benoit, J.B., Lazzari, C.R., Denlinger, D.L., Lahondere, C., 2019. Thermoprotective adaptations are critical for arthropods feeding on warm-blooded hosts. Curr. Opin. Insect. Sci. 34, 7-11.

상세보기
Berridge, M.J., 1970. Osmoregulation in terrestrial arthropods, in: Flokin, M. (Ed.), Chemical zoology V5: Arthropoda Part A, Part 1. Academic Press, New York, pp. 287-316.
Beyenbach, K.W., 2003. Transport mechanisms of diuresis in Malpighian tubules of insects. J. Exp. Biol. 206, 3845-3856.

상세보기
CDC, 2018. Tickborne diseases in the United States: A reference manual for healthcare providers, 5 ed, https://www.cdc.gov/ticks/tickbornediseases/TickborneDiseases-P.pdf (accessed on 20 December, 2020).
Chen, A., Holmes Sp Fau - Pietrantonio, P.V., Pietrantonio, P.V., 2004. Molecular cloning and functional expression of a serotonin receptor from the Southern cattle tick, Boophilus microplus (Acari: Ixodidae). Insect Mol Biol. 13, 45-54.

상세보기
Coast, G.M., 2009. Neuroendocrine control of ionic homeostasis in blood-sucking insects. J. Exp. Biol. 212, 378-386.

상세보기
Coles, T.B., Dryden, M.W., 2014. Insecticide/acaricide resistance in fleas and ticks infesting dogs and cats. Parasites & Vectors 7, 8.

상세보기
Crompton, A.W., Taylor, C.R., Jagger, J.A., 1978. Evolution of homeothermy in mammals. Nature 272, 333-336.

상세보기
Dantas-Torres, F., Chomel, B.B., Otranto, D., 2012. Ticks and tickborne diseases: a one health perspective. Trends Parasitol. 28, 437-446.

상세보기
De la Fuente, J., Estrada-Pena, A., Venzal, J.M., Kocan, K.M., Sonenshine, D.E., 2008. Overview: Ticks as vectors of pathogens that cause disease in humans and animals. Front. Biosci. 13, 6938-6946.
Dipeolu, O.O., Ogunji, F.O., 1980. Laboratory studies on factors influencing the oviposition and eclosion patterns of Amblyomma vagieratum (Fabricius, 1794) females. Folia Parasitol. 27, 257-264.
Freda, T.J., Needham, G.R., 1984. Water exchange kinetics of the long star tick Amblyomma americanum, in: Griffiths, D.A., Bowman, C.E. (Eds.) Acarology Vol.6, Horwood, Chichester, pp. 358-364.
Guglielmone, A.A., Robbins, R.G., Apanaskevich, D.A., Petney, T.N., Estrada-Pena, A., Horak, I.G., Shao, R., Barker, S.C., 2010. The Argasidae, Ixodidae and Nuttalliellidae (Acari: Ixodida) of the world: a list of valid species names. Zootaxa 2528, 1-28.

상세보기
Hackman, R.H., Filshie, B.K. 1982. The tick cuticle, Physiology of Ticks (Vol 1.). Pergamon Press, UK, pp. 1-42.
Hamdy, B.H., Sidrak, W., 1982. Guanine biosynthesis in the Ticks (Acari) Dermacentor Andersoni (Ixodidae) and Argas (Persicargas) Arboreus (Argasidae): Fate of Labelled Guanine Precursors 1, 2. J. Med. Entomol. Suppl. 19, 569-572.

상세보기
Hsu, M.H., and Sauer, J. R., 1974. Sodium, Potassium, Chloride and water balance in the feeding lone star tick, Amblyomma americanum (Linneaus) (Acarina: Ixodidae). J. Kans. Entomol. Soc. 47, 536-537.
Jongejan, F., Uilenberg, G., 2004. The global importance of ticks. Parasitology 129 Suppl, S3-14.

상세보기
Kahl, O., Alidousti, I., 1997. Bodies of liquid water as a source of water gain for Ixodes ricinus ticks (Acari: Ixodidae). Exp. Appl. Acarol. 21, 731-746.

상세보기
Kaufman, W.R., Phillips, J.E., 1973. Ion and water balance in the Ixodid tick Dermacentor Andersoni. I. Routes of Ion and Water Excretion. J. Exp. Biol. 58, 523-536.

상세보기
Kim, D., Maldonado-Ruiz, P., Zurek, L., Park, Y., 2017. Water absorption through salivary gland type I acini in the blacklegged tick, Ixodes scapularis. PeerJ 5, e3984.

상세보기
Kim, D., Simo, L., Park, Y., 2014. Orchestration of salivary secretion mediated by two different dopamine receptors in the blacklegged tick Ixodes scapularis. J. Exp. Biol. 217, 3656-3663.

상세보기
Kim, D., Simo, L., Vancova, M., Urban, J., Park, Y., 2019. Neural and endocrine regulation of osmoregulatory organs in tick: Recent discoveries and implications. Gen. Comp. Endocrinol. 278, 42-49.

상세보기
Kim, D., Urban, J., Boyle, D.L., Park, Y., 2016. Multiple functions of Na/K-ATPase in dopamine-induced salivation of the Blacklegged tick, Ixodes scapularis. Sci. Rep. 6, 21047.

상세보기
Knulle, W., Devine, T.L., 1972. Evidence for active and passive components of sorption of atmospheric water vapour by larvae of the tick Dermacentor variabilis. J. Insect. Physiol. 18, 1653-1664.

상세보기
Lahondere, C., Insausti, T.C., Paim, R.M.M., Luan, X., Belev, G., Pereira, M.H., Ianowski, J.P., Lazzari, C.R., 2017. Countercurrent heat exchange and thermoregulation during blood-feeding in kissing bugs. eLife 6, e26107.

상세보기
Lahondere, C., Lazzari, C.R., 2012. Mosquitoes cool down during blood feeding to avoid overheating. Curr. Biol. 22, 40-45.

상세보기
Lees, A.D., 1946. The water balance in Ixodes ricinus L. and certain other species of ticks. Parasitology 37, 1-20.

상세보기
Lees, A.D., 1948. Passive and active water exchange through the cuticle of ticks. Discuss. Faraday Soc. 3, 187-192.

상세보기
Londt, J.G., Whitehead, G.B., 1972. Ecological studies of larval ticks in South Africa (Acarina: Ixodidae). Parasitology 65, 469-490.

상세보기
Maddrell, S., O'Donnell, M., 1992. Insect Malpighian tubules: V-ATPase action in ion and fluid transport. J. Exp. Biol. 172, 417-429.

상세보기
Maldonado-Ruiz, L.P., Park, Y., Zurek, L., 2020. Liquid water intake of the lone star tick, Amblyomma americanum: Implications for tick survival and management, Scientific Reports. p. 6000.
Meyer-Konig, A., Zahler, M., Gothe, R., 2001. Studies on survival and water balance of unfed adult Dermacentor marginatus and D. reticulatus ticks (Acari: Ixodidae). Exp. Appl. Acarol. 25, 993-1004.

상세보기
Mullen, G.R., Durden, L.A., 2002. Ticks (Ixodida), medical and veterinary entomology. Academic Press, Amsterdam, pp. 517-558.
Needham, G.R., Teel, P.D., 1986. Water balance by ticks between bloodmeals, in: Sauer, J.R., Hair, J.A., (Eds.), Morphology, physiology and behavioral biology of ticks. Ellis Horwood Limited, Chinchester, England, pp. 100-151.
Norval, R.A., 1977. Studies on the ecology of the tick Amblyomma hebraeum Koch in the eastern Cape province of South Africa. II. Survival and development. J. Parasitol. 63, 740-747.

상세보기
Nuttall, P.A., 2019a. Tick saliva and its role in pathogen transmission. Wien. Klin. Wochenschr. 2019, 1-12.
Nuttall, P.A., 2019b. Wonders of tick saliva. Ticks Tick Borne Dis. 10, 470-481.

상세보기
Orchard, I., Leyria, J., Al-Dailami, A., Lange, A.B., 2021. Fluid secretion by malpighian tubules of rhodnius prolixus: Neuroendocrine control with new insights from a transcriptome analysis. Front. Endocrinol. 12, 772487.
WHO, 2014. A global brief on vector-borne diseases. Tech. Rep.
Pant, R., 1988. Nitrogen excretion in insects. Proc. Indian Acad. Sci. (Anim. Sci). 97, 379-415.

상세보기
Pavis, C., Mauleon, H.,Barre, N., Maibeche, M., 1994. Dermal gland secretions of tropical bont tick,Amblyomma variegatum (Acarina: Ixodidae): Biological activity on predators and pathogens. J. Chem. Ecol. 20, 1495-1503.

상세보기
Perner, J., Kropackov a, S., Kopacek, P., Ribeiro J.M.C., 2018. Sialome diversity of ticks revealed by RNAseq of single tick salivary glands. PLoS. Negl. Trop. Dis. 12, 1-17.
Rudolph, D., Knulle, W., 1974. Site and mechanism of water vapour uptake from the atmosphere in ixodid ticks. Nature 249, 84-85.

상세보기
Sauer, J.R., Essenberg, R.C., Bowman, A.S., 2000. Salivary glands in ixodid ticks: control and mechanism of secretion. J. Insect. Physiol. 46, 1069-1078.

상세보기
Sauer, J.R., Hair, J.A., 1971. Water balance in the lone star tick (Acarina: Ixodidae): the effects of relative humidity and temperature on weight changes and total water content. J. Med. Entomol. 8, 479-485.

상세보기
Simo, L., Koci J., Park, Y., 2014. Invertebrate specific D1-like dopamine receptor in control of salivary glands in the blacklegged tick Ixodes scapularis. J. Comp. Neurol. 522, 2038-2052

상세보기
Simo, L., Koci, J., Zitnan, D., Park, Y., 2011. Evidence for D1 dopamine receptor activation by a paracrine signal of dopamine in tick salivary glands. PLoS ONE 6, e16158.

상세보기
Simo, L., Park, Y., 2014. Neuropeptidergic control of the hindgut in the black-legged tick Ixodes scapularis. Int. J. Parasitol. 44, 819-826.

상세보기
Sonenshine, D.E., 1991a. Life cycles of ticks, in: Sonenshine, D.E., Roe, R.M. (Eds.), Biology of ticks, New York, pp. 51-66.
Sonenshine, D.E., 1991b. Water balance in non-feeding ticks, in: Sonenshine, R. (Ed.), In Biology of Ticks, New York, pp. 398-412.
Sonenshine, D.E., 2013. Excretion and water balance: hindgut, malpighian tubules and coxal glands, in: Sonenshine, D.E., Roe, R.M. (Eds.), Biology of ticks. Oxford University Press, New York, pp. 2016-2218.
Sonenshine, D.E., Roe, R.M., 2013a. Biology of Ticks Volume 1. Oxford University Press, Incorporated, Cary, United States.
Sonenshine, D.E., Roe, R.M., 2013b. Biology of Ticks Volume 2. Oxford University Press, Incorporated, Cary, United States.
Splisteser, H., Tyron, U., 1986. Untersuchungen zu faunistischen besonderheiten und zur aktivitat von Dermacentor nuttalli in der Mongolischen Volksrepublik. Monatshefte fur Veterinarmedizin 414, 126-128.
Stobbart, R.H., 1977. The control of the diuresis following a blood meal in females of the yellow fever mosquito Aedes aegypti (L). J. Exp. Biol. 69, 53-85.

상세보기
Terrien, J., Perret, M., Aujard, F., 2011. Behavioral thermoregulation in mammals: a review. Front. Biosci. 16, 1428-1444.

상세보기
Thiemann, T., Fielden, L.J., Kelrick, M.I., 2003. Water uptake in the cat flea Ctenocephalides felis (Pulicidae: Siphonaptera). J. Insect. Physiol. 49, 1085-1092.

상세보기
Valenzuela, J.G., Francischetti, I.M.B., Pham, V.M., Garfield, M.K., Mather, T.N., Ribeiro, J.M.C., 2002. Exploring the sialome of the tick Ixodes scapularis. J. Exp. Biol. 205, 2843-2864.

상세보기
Walker, A.R., Fletcher, J.D., Gill, H.S., 1985. Structural and histochemical changes in the salivary glands of Rhipicephalus appendiculatus during feeding. Int. J. Parasitol. 15, 81-100.

상세보기
Walker, A.R., Lloyd, C., Mcguire, K., Harrison, S.J., Hamilton, J., 1996. Integumental glands of the tick Rhipicephalus appendiculatus (Acari:Ixodidae) as potential producers of semiochemicals. J. Med. Entomol. 33 5, 743-759.

상세보기
Walker, A.R., Lloyd, C.M., McGuire, K., Harrison, S.J., Hamilton, J.G.C., 2014. Integument and Sensillum Auriforme of the Opisthosoma of Rhipicephalus appendiculatus (Acari: Ixodidae). J. Med. Entomol. 33, 734-742.
Wharton, G.W., Richards, A.G., 1978. Water vapor exchange kinetics in insects and acarines. Annu. Rev. Entomol. 23, 309-328.

상세보기
Wigglesworth, V.B., 1931. The physiology of excretion In a bloodsucking insect; Rhodnius prolixus; (Hemiptera, Reduviidae). J. Exp. Biol. 8, 411.

상세보기
Wilkinson, P.R., 1953. Observations on the sensory physiology and behaviour of larvae of the cattle tick, Boophilus Microplus (Can.) (Ixodidae). Aust. J. Zool. 1, 345-356.

상세보기
Yoder, J.A., Benoit, .J.B., Bundy, M.R., Hedges, B. Z., Gribbins, K.M., 2009. Functional morphology of secretion by the large wax glands (Sensilla sagittiformia) Involved in tick defense. Psyche J. Entom. 2009, 1-8.
Yoder, J.A., Hedges, B.Z., Tank, J.L., Benoit, J.B., 2009. Dermal gland secretion improves the heat tolerance of the brown dog tick, Rhipicephalus sanguineus, allowing for their prolonged exposure to host body temperature. J. Therm. Biol. 34, 256-265.

상세보기
Yoder, J.A., Pollack, R.J., Spielman, A., 1993. An ant-diversionary secretion of ticks: First demonstration of an acarine allomone. J. Insect. Physiol. 39, 429-435.

상세보기

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증