$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Morus Nigra Extract Attenuates Cognition Impairment and GABAergic Interneuron Degeneration in Aged Rat Brain 원문보기

Journal of Korean biological nursing science, v.24 no.2, 2022년, pp.77 - 85  

Lee, Joo Hee (Korea Armed Forces Nursing Academy) ,  Kim, Yoonju (Department of Nursing, Graduate School, Kyung Hee University) ,  Song, Min Kyung (Robert Wood Johnson Medical School Institute for Neurological Therapeutics, Rutgers Biomedical and Health Sciences) ,  Kim, Youn-Jung (College of Nursing Science, Kyung Hee University)

Abstract AI-Helper 아이콘AI-Helper

Purpose: Aging process comes with cognitive impairment due to decreased neuronal cell number, activity, and neuronal circuit. Alteration of inhibitory neurons contributes to cognitive impairment in normal aging and is responsible for disrupting the excitation/inhibition balance by reducing the synth...

주제어

참고문헌 (28)

  1. Boss GR, Seegmiller JE. Age-related physiological changes and their clinical significance. Western Journal of Medicine. 1981;135(6):434-440. 

  2. Mather M. Aging and cognition. Wiley Interdisciplinary Reviews: Cognitive Science. 2010;1(3):346-362. https://doi.org/10.1002/wcs.64 

  3. Nimse SB, Pal D. Free radicals, natural anti-oxidants, and their reaction mechanisms. RSC Advances. 2015;5(35):27986-28006. https://doi.org/10.1039/C4RA13315C 

  4. Barrientos RM, Kitt MM, Watkins LR, Maier SF. Neuroinflammation in the normal aging hippocampus. Neuroscience. 2015;309: 84-99. https://doi.org/10.1016/j.neuroscience.2015.03.007 

  5. Hepsomali P, Groeger JA, Nishihira J, Scholey A. Effects of oral gamma-aminobutyric acid (GABA) administration on stress and sleep in humans: a systematic review. Frontiers in Neuroscience. 2020;14:923. https://doi.org/10.3389/fnins.2020.00923 

  6. Lissemore JI, Bhandari A, Mulsant BH, Lenze EJ, Reynolds CF, Karp JF, et al. Reduced GABAergic cortical inhibition in aging and depression. Neuropsychopharmacology. 2018;43:2277-2284. https://doi.org/10.1038/s41386-018-0093-x 

  7. Tremblay R, Lee S, Rudy B. GABAergic Interneurons in the neocortex: from cellular properties to circuits. Neuron. 2016;91(2):260-292. https://doi.org/10.1016/j.neuron.2016.06.033 

  8. Lehmann K, Steinecke A, Bolz J. GABA through the ages: regulation of cortical function and plasticity by inhibitory interneurons. Neural Plasticity. 2012;2012:892784. https://doi.org/10.1155/2012/892784 

  9. Qin C, Li Y, Niu W, Ding Y, Zhang R, Shang X. Analysis and characterisation of anthocyanins in mulberry fruit. Czech Journal of Food Sciences. 2010;28:117-126. https://doi.org/10.17221/228/2008-CJFS 

  10. Tewari RK, Kumar P, Sharma PN. Antioxidant responses to enhanced generation of superoxide anion radical and hydrogen peroxide in the copper-stressed mulberry plants. Planta. 2006;223(6):1145-1153. https://doi.org/10.1007/s00425-005-0160-5 

  11. Zhong Y, Wu S, Chen F, He M, Lin J. Isolation of high γ-aminobutyric acid-producing lactic acid bacteria and fermentation in mulberry leaf powders. Experimental and Therapeutic Medicine. 2019;18(1):147-153. https://doi.org/10.3892/etm.2019.7557 

  12. Vorhees C, Williams M. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nature Protocols. 2006;1:848-858. https://doi.org/10.1038/nprot.2006.116 

  13. Eagle AL, Wang H, Robison AJ. Sensitive assessment of hippocampal learning using temporally dissociated passive avoidance task. Bio-protocol. 2016;6(11):e1821. https://doi.org/10.21769/BioProtoc.1821 

  14. Fougere B, Boulanger E, Nourhashemi F, Guyonnet S, Cesari M. Chronic inflammation: accelerator of biological aging. Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2017;72(9):1218-1225. https://doi.org/10.1093/gerona/glw240 

  15. Christine C. Winterbourn. The biological chemistry of hydrogen peroxide. Methods in Enzymology. 2013;528:3-25. https://doi.org/10.1016/B978-0-12-405881-1.00001-X 

  16. Sheng Y, Abreu IA, Cabelli DE, Maroney MJ, Miller AF, Teixeira M, et al. Superoxide dismutases and superoxide reductases. Chemical Reviews. 2014;114(7):3854-3918. https://doi.org/10.1021/cr4005296 

  17. Board PG, Coggan M, Chelvanayagam G, Easteal S, Jermiin LS, Schulte GK, et al. Identification, characterization, and crystal structure of the omega class glutathione transferases. Journal of Biological Chemistry. 2000;275(32):24798-24806. https://doi.org/10.1074/jbc.M001706200 

  18. Kim Y, Cha SJ, Choi HJ, Kim K. Omega class glutathione s-transferase: Anti-oxidant enzyme in pathogenesis of neurodegenerative diseases. Oxidative Medicine and Cellular Longevity. 2017;2017:5049532. https://doi.org/10.1155/2017/5049532 

  19. Martin DL, Rimvall K. Regulation of γ-aminobutyric acid synthesis in the brain. Journal of Neurochemistry. 1993;60(2):395-407. https://doi.org/10.1111/j.1471-4159.1993.tb03165.x 

  20. Lazarus MS, Krishnan K, Huang ZJ. GAD67 deficiency in parvalbumin interneurons produces deficits in inhibitory transmission and network disinhibition in mouse prefrontal cortex. Cereb Cortex. 2015;25(5):1290-1296. https://doi.org/10.1093/cercor/bht322 

  21. Conde F, Lund JS, Jacobowitz DM, Baimbridge KG, Lewis DA. Local circuit neurons immunoreactive for calretinin, calbindin D-28k or parvalbumin in monkey prefronatal cortex: Distribution and morphology. Journal of Comparative Neurology. 1994;341(1):95-116. https://doi.org/10.1002/cne.903410109 

  22. Ermak G, Davies KJA. Calcium and oxidative stress: from cell signaling to cell death. Molecular Immunology. 2002;38(10):713-721. https://doi.org/10.1016/s0161-5890(01)00108-0 

  23. Miller JB, Pratap A, Miyahara A, Zhou L, Bornemann S, Morris RJ, et al. Calcium/calmodulin-dependent protein kinase is negatively and positively regulated by calcium, providing a mechanism for decoding calcium responses during symbiosis signaling. Plant Cell. 2013;25(12):5053-5066. https://doi.org/10.1105/tpc.113.116921 

  24. Caillard O, Moreno H, Schwaller B, Llano I, Celio MR, Marty A. Role of the calcium-binding protein parvalbumin in short-term synaptic plasticity. The Proceedings of the National Academy of Sciences. 2000;97(24):13372-13377. https://doi.org/10.1073/pnas.230362997 

  25. Iascone DM, Li Y, Sumbul U, Doron M, Chen H, Andreu V, et al. Whole-neuron synaptic mapping reveals spatially precise excitatory/inhibitory balance limiting dendritic and somatic spiking. Neuron. 2020;106(4):566-578. https://doi.org/10.1016/j.neuron.2020.02.015 

  26. Lam NH, Borduqui T, Hallak J, Roque AC, Anticevic A, Krystal JH, et al. Effects of altered excitation-inhibition balance on decision making in a cortical circuit model. bioRxiv. 2017; 42(6):1035-1053. https://doi.org/10.1523/JNEUROSCI.1371-20.2021 

  27. Lopatina OL, Malinovskaya NA, Komleva YK, Gorina YV, Shuvaev AN, Olovyannikova RY, et al. Excitation/inhibition imbalance and impaired neurogenesis in neurodevelopmental and neurodegenerative disorders. Reviews in the Neurosciences. 2019;30(8):807-820. https://doi.org/10.1515/revneuro-2019-0014 

  28. McQuail JA, Frazier CJ, Bizon JL. Molecular aspects of age-related cognitive decline: the role of GABA signaling. Trends in Molecular Medicine. 2015;21(7):450-460. https://doi.org/10.1016/j.molmed.2015.05.002 

관련 콘텐츠

오픈액세스(OA) 유형

GOLD

오픈액세스 학술지에 출판된 논문

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로