[논문]승모판의 인공판막 치환술후 삼부주사액의 심근보호효과에 관한 체계적 문헌고찰 및 메타분석

신봉진; 김지호; 안무혁; 권정남

doi:10.13048/jkm.22038

승모판의 인공판막 치환술후 삼부주사액의 심근보호효과에 관한 체계적 문헌고찰 및 메타분석
Myocardial Protective Effects of Shenfu Injection after Mitral Valve Replacement Surgery; A Systematic Review and Meta Analysis. 원문보기

Journal of Korean Medicine = 대한한의학회지, v.43 no.3, 2022년, pp.164 - 180

신봉진 (부산대학교 한의학전문대학원) , 김지호 (부산대학교 한의학전문대학원) , 안무혁 (부산대학교 한의학전문대학원) , 권정남 (부산대학교 한의학전문대학원)

Abstract ▼ AI-Helper

Objectives: The purpose of this study was to evaluate the effects of shenfu injection on myocardial protective effects after mitral valve replacement surgery. Methods: We searched four international databases (PUBMED, Embase, Web of Science and CNKI) and three domestic electronic databases (OASIS, RISS and NDSL) for relevant studies. We used following keywords 'shenfu', 'valve replacement', 'mitral valve' at PUBMED, Embase and Web of Science; '二尖瓣', '参附注射液', '瓣膜' at CNKI and '이첨판', '판막', '삼부' at domestic databases. The search range included randomized controlled trials. When appropriate, meta-analyses were performed. Results: Seven randomized controlled trials were selected. All studies used Shenfu injection after mitral valve replacement surgery. We analyzed myocardial damage, cardiac function, patients' recovery rate, with various evaluation indicators. We also used meta-analysis for CK-MB, cTnI, MDA and voluntary recovery of heartbeat. CK-MB was analyzed in two subgroups: 8 hours and 24 hours after surgery. Std was -2.34(95% CI -4.10, -0.58) for 8 hours and -1.95(95% CI -4.79 to 0.88) for 24 hours. 8 hours showed statistically significant difference. cTnI appeared significant decrease with Std of -2.13(95% CI -2.60, -1.66). MDA showed significant decrease with Std of -0.95(95% CI -1.43 to -0.47). Voluntary recovery of heartbeat significantly increased with the odd ratio of 4.34(95% CI 1.76, 10.70). Conclusions: We suggest that Shenfu injection after Mitral valve replacement surgery may have significant myocardial protective effects in terms of reducing myocardial damages, reactive oxygen species, increasing cardiac function and patients' recovery after surgery. However, the evidence is limited, further research is required.

주제어

표/그림 (10)

그림 Fig 1. PRISMA flow chart.
표 Table 1. Characteristics of Selected studies
표 Table 2. Characteristics of Selected studies
그림 Fig 2. The meta results of CK-MB in 8 hours (SFI vs Control goup).
그림 Fig 3. The meta results of CK-MB in 24 hours (SFI vs Control goup).
그림 Fig 4. The meta results of cTnI in 8 hours (SFI vs Control goup).
그림 Fig 5. The meta results of MDA in 24 hours (SFI vs Control goup).
그림 Fig 6. The meta results of Voluntary recovery of heartbeat (SFI vs Control goup).
그림 Fig 7. Risk of bias summary.
그림 Fig 8. Risk of bias graph.

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표제어: PCR

동의어: Packet Collision Rate

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용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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