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중간엽줄기세포(MSC)를 이용한 허혈성 혈관질환 치료를 위한 세포치료제 개발: 기초연구에서 임상연구
Development of Cell Therapeutics against Ischemic Vascular Diseases Using Mesenchymal Stem Cells: From Bench to Bed 원문보기

생명과학회지 = Journal of life science, v.32 no.7, 2022년, pp.567 - 577  

이은지 (부산대학교 의과대학 의학연구소 생리학교실) ,  박신후 (부산대학교 의과대학) ,  서정호 (부산대학교 의과대학) ,  안효경 (부산대학교 의과대학) ,  남시현 (부산대학교 의과대학) ,  권상모 (부산대학교 의과대학 의학연구소 생리학교실)

초록
AI-Helper 아이콘AI-Helper

최근 인구 고령화로 인해 허혈성 심장질환, 허혈성 뇌졸중, 말초 동맥 질환 등의 허혈성 혈관질환의 유병률이 지속적으로 증가하고 있다. 허혈성 질환에 대한 현재 표준화된 치료법은 약물 요법 및 수술을 통한 재관류요법이다. 재관류요법은 손상된 동맥의 기능을 회복시킬 수 있지만 허혈로 인해 손상된 주변 조직의 기능 회복에 있어 효율적이지 않다. 그러므로 허혈 질병을 안전하고 효과적으로 치료하고 주변 조직의 기능을 회복시킬 수 있는 새로운 치료전략의 개발이 필요하다. 이러한 한계를 극복하기 위해 손상된 부위를 재생하는 줄기세포 기반 치료가 허혈성 혈관질환의 유망한 전략으로 연구되어 왔다. 다양한 조직에서 분리할 수 있는 중간엽줄기세포(MSC)는 면역 조절, 혈관 신생 촉진 및 다양한 관련 인자의 분비를 통해 손상된 조직을 재생함으로써 허혈성 질환의 치료에 유망한 것으로 나타났다. 또한, 줄기세포 치료 효과를 높이기 위해 3D 배양법을 이용하거나 세포 프라이밍(Cell Priming)과 같은 MSC 기능을 강화하여 이식 효율을 높이는 새로운 접근법이 연구되고 있다. 이 논문에서는 MSC를 허혈성 질환 치료에 사용하는 다양한 전략을 제공하고 허혈성 부위에서 MSC의 분화(Differentiation), 증식(Proliferation) 및 생착(Engraftment)과 같은 이식의 문제에 대해 논의한다.

Abstract ▼ AI-Helper 아이콘AI-Helper

Recently, the prevalence of ischemic diseases, such as ischemic heart disease, cerebral ischemia, and peripheral arterial disease, has been continuously increasing due to the aging population. The current standardized treatment for ischemic diseases is reperfusion therapy through pharmacotherapy and...

주제어

#Ischemic heart disease   #Ischemic stroke   #Mesenchymal stem cells   #Peripheral artery disease   #stem cell therapy  

표/그림 (3)

AI 본문요약
AI-Helper 아이콘 AI-Helper

문제 정의

  • 본 논문에서는 먼저, 세포치료제로서 MSC의 특징을 비교하고, 이를 적용할 때 세포 프라이밍 기술의 개념에서의 세포치료제 개발을 위한 학문적인 이해를 돕고자 하며 실제 임상 적용을 통해 MSC를 사용한 세포 치료의 가능성과 동향을 소개하고자 한다.
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참고문헌 (94)

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