[논문]『동의보감(東醫寶鑑)』 풍문(風門) 처방 및 구성 약재의 인용 빈도 분석을 통한 전임상 연구 후보 약재 선별

임지연; 임세현; 이병호; 조수인

doi:10.14374/hfs.2022.30.3.165

『동의보감(東醫寶鑑)』 풍문(風門) 처방 및 구성 약재의 인용 빈도 분석을 통한 전임상 연구 후보 약재 선별
Selection for preclinical study candidate through analysis of frequently used medications presented in Donguibogam Stroke chapter 원문보기

大韓韓醫學方劑學會誌 = Herbal formula science, v.30 no.3, 2022년, pp.165 - 174

임지연 (동국대학교 의과대학) , 임세현 (극동대학교 의료보건과학대학) , 이병호 (인주한방병원) , 조수인 (부산대학교 한의학전문대학원)

Abstract ▼ AI-Helper

Objectives: Donguibogam has helped progress of Eastern medicine across Asia and almost all of Korean medicine doctors still use the book as a classic reference. In this study, the prescriptions used in the treatment of stroke in Donguibogam are analyzed and the results are to be used for our subsequent studies. Methods: The frequency of use of prescriptions and the frequency of combination of medicines were analyzed from 89 prescriptions used in the Stroke chapter of Donguibogam, and it was intended to derive a combination prescription and a monosyllabic medicine that can be effectively used in the treatment of stroke for preclinical studies. Results: Ganghwalyupung-tang (羌活愈風湯) was the most mentioned prescription among 89 prescriptions, and Glycyrrhizae Radix et Rhizoma, among 165 species of medicines used in the 89 prescriptions, mixed in 55 prescriptions. However, considering the ratio of frequently used medicines, Sagunja-tang (四君子湯) was the highest in terms of composition ratio. Conclusions: Through this study, Glycyrrhizae Radix et Rhizoma and Sagunja-tang were selected as materials for our subsequent studies.

주제어

표/그림 (6)

표 Table 1. Analysis of prescriptions and frequency recorded in Stroke chapter of Donguibogam.
표 Table 2. Analysis of frequency of the combination of medicinal herbs used in the prescriptions recorded in Stroke chapter of Donguibogam.
그림 Fig. 1. The frequency of prescriptions used for the treatment of stroke in the Stroke chapter of Donguibogam is shown in the form of word cloud. The larger the size of the letter, the more cited it is. Therefore, it can be seen that Ganghwalyupung-tang (羌活愈風湯) and Bangpungtongseong-san (防風通聖散) were used with the highest frequency.
그림 Fig. 2. The frequency of use of herbal medicines mixed in prescriptions used for stroke treatment in the Stroke chapter of Donguibogam is shown in the form of word cloud. The larger the size of the letter, the more often it is mixed in the prescription. Therefore, it can be seen that Glycyrrhizae Radix et Rhizoma, Saposhnikoviae Radix, and Zingiberis Rhizoma were used at the highest frequency.
그림 Fig. 3. The network of 89 prescriptions used for the treatment of stroke and 165 kinds of medicines mixed in the Stroke chapter of Donguibogam is schematized. The large number of solid lines connected to the medicines means that the number of prescriptions mixed with this medicine is large, and it can be seen that such solid lines appeared in medicines such as licorice and windbreak.
그림 Fig. 4. Analysis of the network of combination prescription with 10 species of medicines for stroke. Many solid lines connecting medicines and prescriptions means that among the 10 species medicines, the number of medicines mixed in the prescription is large. In other words, in the case of Geopungjeseup-tang (祛風除濕湯), it shows that 9 medicines, excluding Arisaematis Rhizoma, are mixed among the 10 medicines.

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원문보기 상세보기
Lee SE, Lim C, Cho S. Angelica gigas root ameliorates ischaemic stroke-induced brain injury in mice by activating the PI3K/AKT/mTOR and MAPK pathways. Pharm Biol. 2021; 59(1):662-71.

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