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미선나무 꽃 색에 따른 생리활성 화합물 및 항염증 활성 비교
Comparison of the bioactive compounds and anti-inflammatory effects found in different flower colors from Abeliophyllum distichum Nakai 원문보기

Journal of applied biological chemistry, v.65 no.3, 2022년, pp.203 - 213  

장태원 (Department of Pharmaceutical Science, Jungwon University) ,  최지수 (NST BIO Co., Ltd.) ,  한소연 (Department of Medicinal Plant Science, Jungwon University) ,  박혜정 (Department of Medicinal Plant Science, Jungwon University) ,  이다윤 (Department of Medicinal Plant Science, Jungwon University) ,  민영실 (Department of Pharmaceutical Science, Jungwon University) ,  박재호 (Department of Pharmaceutical Science, Jungwon University)

초록
AI-Helper 아이콘AI-Helper

미선나무(Abeliophyllum distichum) 1속 1종의 한반도 고유식물이다. 꽃잎색의 변이에 따라 미선(백색), 분홍미선, 상아미선 그리고 연노랑색의 옥황1호 품종 등으로 구분된다. 본 연구에서는 4종류의 꽃 추출물(FAD)로부터 생리활성물질의 함량과 항염증 활성 차이를 비교·분석하였다. FAD의 생리활성 물질은 LC/MS 분석을 통해 rutin, hirsutrin, 그리고 acteoside를 분석하였다. DPPH와 ABTS 라디칼 소거활성을 통한 항산화 활성을 분석하였으며, 항산화 활성은 각 추출물의 생리활성 물질의 함량에 따라 유의성 있는 활성을 나타내었다. FAD는 LPS로 유도된 RAW 264.7 세포에서 염증 유발 매개체(산화질소, iNOS, COX-2)의 발현을 감소시켰다. 또한 NF-κB와 MAPK 신호전달 경로 조절을 통한 항염증 효과를 확인하였다.

Abstract AI-Helper 아이콘AI-Helper

Abeliophyllum distichum (A. distichum, Korean endemic plant) is one genus and one species in the Oleaceae family. According to the color variation of petals and calyx, A. distichum is classified as A. distichum (white flower), A. distichum for. lilacinum (pink flowers), A. distichum for. eburneum (i...

주제어

참고문헌 (41)

  1. Libby P (2007) Inflammatory mechanisms: the molecular basis of inflammation and disease. Nutr reviews 65: S140-S146. doi: 10.1111/j.1753-4887.2007.tb00352.x 

  2. Maxwell SR (1995) Prospects for the use of antioxidant therapies. Drugs 49: 345-361. doi: 10.2165/00003495-199549030-00003 

  3. World Health Organization (2019) Global action plan on physical activity 2018-2030: more active people for a healthier world. World Health Organization, Geneva 

  4. Ames BN, Shigenaga MK, Hagen TM (1993) Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci 90: 7915-7922. doi: 10.1073/pnas.90.17.7915 

  5. Braca A, Sortino C, Politi M, Morelli I, Mendez J (2002) Antioxidant activity of flavonoids from Licania licaniaeflora. J Ethnopharmacol 79: 379-381. doi: 10.1016/S0378-8741(01)00413-5 

  6. Aktan F (2004) iNOS-mediated nitric oxide production and its regulation. Life Sci 75: 639-653. doi: 10.1016/j.lfs.2003.10.042 

  7. Schletter J, Heine H, Ulmer AJ, Rietschel ET (1995) Molecular mechanisms of endotoxin activity. Arch Microbiol 164: 383-389. doi: 10.1007/BF02529735 

  8. Sweet MJ, Hume DA (1996) Endotoxin signal transduction in macrophages. J Leukoc Biol 60: 8-26. doi: 10.1002/jlb.60.1.8 

  9. Ulevitch R, Tobias P (1995) Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu Rev Immunol 13: 437-457. doi: 10.1146/annurev.iy.13.040195.002253 

  10. Meng Z, Yan C, Deng Q, Gao D-f, Niu X-l (2013) Curcumin inhibits LPS-induced inflammation in rat vascular smooth muscle cells in vitro via ROS-relative TLR4-MAPK/NF-κB pathways. Acta Pharmacol Sin 34: 901-911. doi: 10.1038/aps.2013.24 

  11. Hwang P-A, Chien S-Y, Chan Y-L, Lu M-K, Wu C-H, Kong Z-L, Wu C-J (2011) Inhibition of lipopolysaccharide (LPS)-induced inflammatory responses by Sargassum hemiphyllum sulfated polysaccharide extract in RAW 264.7 macrophage cells. J Agric Food Chem 59: 2062-2068. doi: 10.1021/jf1043647 

  12. Kim YS, Maunder M (1998) Plants in peril, 24 Abeliophyllum distichum. Curtis's Bot Mag: 141-146 

  13. Park J, Kim Y, Xi H, Jang T, Park J-H (2019) The complete chloroplast genome of Abeliophyllum distichum Nakai (Oleaceae), cultivar Ok Hwang 1ho: insights of cultivar specific variations of A. distichum. Mitochondrial DNA Part B 4: 1640-1642. doi: 10.1080/23802359.2019.1605851 

  14. Shin HT, Yi MH, Kim YS, Lee BC, Yoon JW (2010) Recently augmented natural habitats of Forsythia koreana (Rehder) Nakai and Abeliophyllum distichum Nakai in Korea. Korean J Pl Taxon 40: 274-277. doi: 10.11110/kjpt.2010.40.4.274 

  15. Oh H, Kang DG, Kwon TO, Jang KK, Chai KY, Yun YG, Chung HT, Lee HS (2003) Four glycosides from the leaves of Abeliophyllum distichum with inhibitory effects on angiotensin converting enzyme. Phytother Res 17: 811-813. doi: 10.1002/ptr.1199 

  16. Hayashi K, Nagamatsu T, Ito M, Yagita H, Suzuki Y (1996) Acteoside, a component of Stachys sieboldii MIQ, may be a promising antinephritic agent (3): effect of acteoside on expression of intercellular adhesion molecule-1 in experimental nephritic glomeruli in rats and cultured endothelial cells. Japanese J Clin Pharmacol Ther 70: 157-168. doi:10.1254/jjp.70.157 

  17. Kim S-S, Son Y-O, Chun J-C, Kim S-E, Chung G-H, Hwang K-J, Lee J-C (2005) Antioxidant property of an active component purified from the leaves of paraquat-tolerant Rehmannia glutinosa. Redox Rep 10: 311-318. doi: 10.1179/135100005X83734 

  18. Xiong Q, Hase K, Tezuka Y, Tani T, Namba T, Kadota S (1998) Hepatoprotective activity of phenylethanoids from Cistanche deserticola. Planta Med 64: 120-125. doi: 10.1055/s-2006-957387 

  19. Janbaz KH, Saeed SA, Gilani AH (2002) Protective effect of rutin on paracetamol-and CCl4-induced hepatotoxicity in rodents. Fitoterapia 73: 557-563. doi: 10.1016/S0367-326X(02)00217-4 

  20. Park GH, Park JH, Eo HJ, Song HM, Lee MH, Lee JR, Jeong JB (2014) Anti-inflammatory effect of the extracts from Abeliophyllum distichum Nakai in LPS-stimulated RAW264. 7 cells. Korean J Plant Res 27: 209-214. doi: 10.7732/kjpr.2014.27.3.209 

  21. Ahn J, Park JH (2013) Effects of Abeliophyllum distichum Nakai flower extracts on antioxidative activities and inhibition of DNA damage. Korean J Plant Res 26: 355-361. doi: 10.7732/kjpr.2013.26.3.355 

  22. Jang T-W, Park J-H (2021) Anti-Inflammatory Effects of Abeliophyllum distichum Nakai (Cultivar Okhwang 1) Callus through Inhibition of PI3K/Akt, NF-κB, and MAPK Signaling Pathways in Lipopolysaccharide-Induced Macrophages. Processes 9: 1071. doi: 10.3390/pr9061071 

  23. Bondet V, Brand-Williams W, Berset C (1997) Kinetics and mechanisms of antioxidant activity using the DPPH. free radical method. LWT-FOOD SCI TECHNOL 30: 609-615. doi: 10.1006/fstl.1997.0240 

  24. van den Berg R, Haenen GR, van den Berg H, Bast A (1999) Applicability of an improved Trolox equivalent antioxidant capacity (TEAC) assay for evaluation of antioxidant capacity measurements of mixtures. Food Chem 66: 511-517. doi: 10.1016/S0308-8146(99)00089-8 

  25. Oyaizu M (1986) Studies on products of browning reaction antioxidative activities of products of browning reaction prepared from glucosamine. Japanese J Nutr Diet 44: 307-315. doi: 10.5264/eiyogakuzashi.44.307 

  26. Singleton VL, Rossi JA (1965) Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Vitic 16: 144-158 

  27. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method. Methods 25: 402-408. doi: 10.1006/meth.2001.1262 

  28. Caban M, Chojnacka K, Owczarek K, Laskowska J, Fichna J, Podsedek A, Sosnowska D, Lewandowska U (2020) Spent hops (Humulus lupulus L.) extract as modulator of the inflammatory response in lipopolysaccharide stimulated raw 264.7 macrophages. J Physiol Pharmacol 70: 67-78. doi: 10.26402/jpp.2020.1.05 

  29. Schulze-Osthoff K, Ferrari D, Riehemann K, Wesselborg S (1997) Regulation of NF-κB activation by MAP kinase cascades. Immunobiology 198: 35-49. doi: 10.1016/S0171-2985(97)80025-3 

  30. Choe S, Yang K (1982) Toxicological studies of antioxidants, butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA). Korean J Food Sci Technol 14: 283-288 

  31. Deschner EE, Ruperto J, Wong G, Newmark HL (1991) Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia. Carcinogenesis 12: 1193-1196. doi: 10.1093/carcin/12.7.1193 

  32. Shanely RA, Knab AM, Nieman DC, Jin F, McAnulty SR, Landram MJ (2010) Quercetin supplementation does not alter antioxidant status in humans. Free Radic Res 44: 224-231. doi: 10.3109/10715760903407293 

  33. Schlesier K, Harwat M, Bohm V, Bitsch R (2002) Assessment of antioxidant activity by using different in vitro methods. Free Radic Res 36: 177-187. doi: 10.1080/10715760290006411 

  34. Xie J (1993) Effect of ethanolic extract of Cistanche deserticola on the contents of monoamine neurotransmitters in rat brain. Chin Trad Herb Drugs 24: 417-419 

  35. Kroncke K-D, Fehsel K, Kolb-Bachofen V (1997) Nitric oxide: cytotoxicity versus cytoprotection-how, why, when, and where? Nitric oxide 1: 107-120. doi: 10.1006/niox.1997.0118 

  36. Hofseth LJ, Hussain SP, Wogan GN, Harris CC (2003) Nitric oxide in cancer and chemoprevention. Free Radic Biol Med 34: 955-968. doi: 10.1016/S0891-5849(02)01363-1 

  37. Liew F (1994) Regulation of nitric oxide synthesis in infectious and autoimmune diseases. Immunol Lett 43: 95-98. doi: 10.1016/0165-2478(94)00157-X 

  38. Gilmore TD (2006) Introduction to NF-κB: players, pathways, perspectives. Oncogene 25: 6680-6684. doi: 10.1038/sj.onc.1209954 

  39. Hommes D, Peppelenbosch M, Van Deventer S (2003) Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets. Gut 52: 144-151. doi: 10.1136/gut.52.1.144 

  40. Yoo T-K, Kim J-S, Hyun TK (2020) Polyphenolic composition and anti-melanoma activity of white forsythia (Abeliophyllum distichum nakai) organ extracts. Plants 9: 757. doi: 10.3390/plants9060757 

  41. Choi J, Kim H, Hyun T (2018) Transcriptome analysis of Abeliophyllum distichum NAKAI reveals potential molecular markers and candidate genes involved in anthocyanin biosynthesis pathway. S Afr J Bot 116: 34-41. doi: 10.1016/j.sajb.2018.02.401 

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