[논문]Helianthus annuus (Sunflower) Seed Oil 의 항염 및 피부 개선 효과 연구

소지민; 남개원

doi:10.15230/scsk.2023.49.4.331

Helianthus annuus (Sunflower) Seed Oil 의 항염 및 피부 개선 효과 연구
Study on Effect of Skin Soothing by Helianthus annuus (Sunflower) Seed Oil 원문보기

大韓化粧品學會誌 = Journal of the society of cosmetic scientists of Korea, v.49 no.4, 2023년, pp.331 - 339

소지민 ((주)유로핀즈씨알에이) , 남개원 (서원대학교 바이오코스메틱학과)

초록
AI-Helper

본 연구에서는 Helianthus annuus (Sunflower) seed oil의 in vitro 시험 및 인체적용시험을 통해 항염 효과와 피부 보습, 피지 분비, 피부 장벽기능 개선 및 피부 진정 등 피부 개선 효과를 확인하였다. In vitro 시험 결과, lipopolysaccharide로 염증 반응을 유도한 각질형성세포(cultured human epidermal keratinocytes)에 H. annuus (Sunflower) seed oil을 처리하였을 때 염증성 사이토카인인 IL-6, IL-8, TNF-α가 통계적으로 유의하게 감소하여 항염 효과가 있음을 확인하였다. 또한 H. annuus (Sunflower) seed oil을 함유한 시험제품을 제조하여 민감성 피부 대상으로 4 주간 인체적용시험한 결과, 피부 보습, 피지 분비, 피부 장벽이 개선되었으며, 피부 붉은기와 트러블이 개선되는 등 피부 개선 효과를 확인하였다. 본 연구 결과를 통해 민감성 피부를 타겟으로 한 화장품 원료로서 H. annuus (Sunflower) seed oil의 가능성을 확인하였다.

Abstract ▼ AI-Helper

In this study, in vitro and clinical studies were conducted to assess the anti-inflammatory effects and skin improvement effects, including moisturizing, sebum secretion-regulating, skin barrier function enhancing, and soothing of Helianthus annuus (Sunflower) seed oil. In in vitro study using cultured human epidermal keratinocytes induced with inflammation by lipopolysaccharide, significant decreases in inflammatory cytokines interleukin-6, interleukin-8, and tumor necrosis factor alpha was revealed, indicating the anti-inflammatory effects of H. annuus (Sunflower) seed oil. Additionally, the results of clinical study on subjects with sensitive skin demonstrated improved skin hydration, regulation of sebum secretion, enhanced skin barrier function, as well as amelioration of skin redness and acne, indicating positive effects on overall skin conditions after application of H. annuus (Sunflower) seed oil containing test product for 4 weeks. Results of this study demonstrated the potential of H. annuus (Sunflower) seed oil as an ingredient for cosmetic, targeting consumers with sensitive skin.

주제어

표/그림 (9)

표 Table 1. Ingredients of the Test Product
그림 Figure 1. Activation of cannabinoid receptor 1 (CB1R) by H. annuus (Sunflower) Seed Oil.
표 Table 2. Modified Global Acne Grading System (GAGS)
그림 Figure 2. Anti-inflammatory activity of H. annuus (Sunflower) Seed Oil in cultured human epidermal keratinocytes. Figure 1(A) IL-6, Figure 1(B) IL-8, Figure 1(C) TNF-α. Comparison of LPS + blank vs. LPS + H. annuus (Sunflower) Seed Oil 5 μg/mL and LPS + AEA 1 μM, Student's t-test, * p < 0.05.
그림 Figure 3. Results of hydration intensity measurement. Mean ± SE. Comparison before and after, Wilcoxon signed-rank test, * p < 0.05.
그림 Figure 4. Results of sebum secretion rate measurement. Mean ± SE. Comparison before and after, Wilcoxon signed-rank test, ** p < 0.01, *** p < 0.001.
그림 Figure 5. Results of transepidermal water loss measurement. Mean ± SE. Comparison before and after, Wilcoxon signed-rank test, *** p < 0.001.
그림 Figure 6. Results of image analysis of redness area. Mean ± SE. Comparison before and after, paired t-test, * p < 0 . 05.
그림 Figure 7. Results of dermatologist's evaluation of acne. Mean ± SE. Comparison before and after, Wilcoxon signed-rank test, *** p < 0. 001.

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